A review.Iron oxides, including wustite (FeO), hematite (α-Fe2O3), maghemite (γ-Fe2O3), and magnetite (Fe3O4), are remarkable nanomaterials.Iron oxide nanoparticles (IONPs) at the nanoscale display super-paramagnetic, high surface area, and biocompatibility, making them ideal for diverse applications.Their influence on matter behavior, interaction with light, electricity, magnetism, and non-toxicity in biol. systems make them promise in biomedicine.This review covers IONPs properties, emphasizing biol., chem., and phys. synthesis methods, including doping, coating, and encapsulation.In addition, advancing green synthesis approaches for IONPs are highlighted.We explore their applications in medicine, environmental science, and pollution solutions, emphasizing their merits.Examining various IONPs and synthesis routes, we underscore their role in addressing global challenges.IONPs versatility, scalability, and eco-friendliness position them to transform research and uphold ethical standardsThis review unveils the transformative potential of Iron Oxide Nanoparticles (IONPs), emphasizing their unique attributes-biocompatibility, magnetic responsiveness, and tunable surface functionalities.IONPs are pivotal in targeted drug delivery, imaging, hyperthermia therapy, and biosensing.The comprehensive exploration spans biomedical, agricultural, antioxidant, and photocatalytic applications, showcasing IONPs versatility in advancing innovative solutions across diverse domains.Our collective efforts aim to revolutionize medical treatments, combat environmental issues, and foster a sustainable future while advocating responsible research and ethics.