Sanjiu Enterprise Group

The immunopharmacol. action of total paeonia glucosides injection (TPGI) in mice was studied.Effects of TPGI on delayed hypersensitivity, carbon clearance, hemolysin response, immune organ weight and spleen lymphocyte proliferation in mice were observedTPGI at 200-300 mg/kg i.p. per day for 7 days could remarkably decrease the delayed hypersensitivity and carbon clearance, and 64-256 μg/mL TPGI could inhibit the spleen lymphocyte proliferation induced by ConA.TPGI in proper dose could depress special cellular immune response and the function of the mononuclear cell, macrophage and T lymphocyte.

Freeze-dried doxorubicin liposomes were prepared, and the therapeutic effects and toxicity of doxorubicin (DOX) and liposomal doxorubicin (Lip-DOX) were compared.Lip-DOX was less toxic than DOX after i.v. administration in tumor-bearing animals, and superior to DOX at equal doses in the S₁₈₀, U₁₄, P₈₈₈ tumor models.

Total Glucoside of Paeony (TGP) was extracted from Paeonia lactiflora Pall.The production technol. of TGP was described.The cost of the production was greatly decreased as the yield of TGP increased from about 3 to >5% with desirable quantity.