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项与 Oculon Corp 相关的药物

Pantethine

泛硫乙胺

靶点

RT

作用机制

RT抑制剂

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1977-09-28

100 项与 Oculon Corp 相关的临床结果

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0 项与 Oculon Corp 相关的专利（医药）

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项与 Oculon Corp 相关的文献（医药）

1997-01-01·Current Eye Research4区 · 医学

Quasielastic light scattering study of the living human lens as a function of age

4区 · 医学

Article

作者: Kandel, J ; Benedek, G B ; Hayden, D L ; Peetermans, J A ; Storb, R ; Sullivan, K M ; Courogen, M ; Stern, H ; Burrows, P ; Bowen, M S ; Clark, J I ; Miller, D ; Taret, V G ; Thurston, G M

PURPOSETo determine contributions of molecular scattering elements to the increase with age in the light scattered from the human ocular lens in vivo.METHODSWe used quasielastic light scattering to measure autocorrelation functions of the intensity of light scattered in vivo from three locations (anterior, nuclear and posterior) along the optic axis in ocular lenses of 225 subjects, ranging from 17 to 63 years of age. We deduced probability distributions of key parameters (Is, If, Ii, IT), which describe contributions of slowly diffusing (Is), rapidly diffusing (If) and relatively immobile (Ii) scattering elements to the total light intensity (IT) scattered into the collection optics. We deduced characteristic time tau s and tau f that describe the Brownian motion of scattering elements.RESULTSProbability distributions for each age decile show clearly defined shifts in key parameters with age. IT at the nucleus increases by a factor of three from age 20 to 60 years. This increase is produced principally by an approximate five-fold increase is Is. IT and Is and can be detected with an accuracy of approximately +/- 10%. We estimate threshold values for IT, which mark the boundary beyond which clinical cataract becomes manifest. This boundary represents 6 to 8 times the light scattering efficiency expected from the newborn lens.CONCLUSIONSThis methodology permits a sensitive, quantitative, clinically useful representation of the pre-cataractous molecular changes associated with aging in the living human lens.

100 项与 Oculon Corp 相关的药物交易

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100 项与 Oculon Corp 相关的转化医学

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