Stuart Pharmaceuticals

The gross and histopathologic findings seen in the stomachs of rats and mice treated with 2 different H2 receptor antagonists are presented. Studies with the first drug, ICI 125,211, elicited dysplasia/carcinoma lesions in 17 of 828 treated rats with 12 of the 17 lesions occurring in the pyloric region of the stomach. No tumors occurred in mice on study for 18 months. Studies conducted with another drug candidate, ICI 162,846, produced neuroendocrine carcinomas in the stomach of rats and mice. Twenty-five rats out of 312 treated male and female rats had neuroendocrine carcinomas in the gastric fundus with a higher tumor incidence in females. In a 24-month mouse study with ICI 162,846, 45 of 300 treated mice developed neuroendocrine carcinomas in the gastric fundus with a higher incidence in males.

The use of coated 1 mm glass beads is promising for recycle gas chromatog.In the case of an SE-30 column, the glass beads generate plates faster than porous packings as fine as 48/60 mesh.Although packings coated with SE-30 produce nearly 400,000 plates, they are unable to fractionate a mixture of benzene and perdeuterobenzene.However, a much less efficient squalane column successfully fractionates that mixture after approx. 60,000 plates, confirming earlier work in which squalane was used.Coated beads appear to be especially useful when large numbers of plates are required and mg amounts of product are needed.