The purpose of this study was to evaluate the effectiveness of combinational vaccines for preventing foot-and-mouth disease(FMD), classical swine fever(CSF), and pseudorabies(PR) in pig farms. Vaccines for FMD, CSF and PR were obtained com. and combined, and the phys. properties and potency of the combinational vaccines were assessed. Nursery pigs(2 500), gilts(1 000), and multiparous sows(1 000) were selected from pig farms and divided into 5 groups(A, B, C, D, E), and injection with the combinational vaccines. Specific antibody titers to FMD, CSF, and PR were detected by ELISA kits. The results showed that combinational vaccines were phys. stable, and pigs immunized with the combinational vaccines generated high titers of specific antibodies to FMD, CSF, and PR, even higher after second dose. With relatively few side effects, infrequent doses, and reduced contact with human personnel, combinational vaccines offer efficient approach to prevent FMD, CSF, and PR in pig farms.