Delving into the Latest Updates on Monash University, Clayton campus with Synapse

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项与 Monash University, Clayton campus 相关的药物

AM-36

靶点

σ1 receptor

作用机制

σ1 receptor调节剂

在研机构-

原研机构

CSL Innovation Pty Ltd.

在研适应症-

非在研适应症

阿尔茨海默症 [+3]

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

100 项与 Monash University, Clayton campus 相关的临床结果

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0 项与 Monash University, Clayton campus 相关的专利（医药）

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24,806

项与 Monash University, Clayton campus 相关的文献（医药）

2024-09-01·Physiotherapy Theory and Practice

Career intentions and satisfaction influences in early career Australian physiotherapists

Article

作者: Hay, Margaret ; Paynter, Sophie ; Iles, Ross ; Hodgson, Wayne C.

BACKGROUNDThe current workforce does not meet the demand for physiotherapy services in Australia. Future demand is predicted to expand driven primarily by the aging population. Previous research describes significant attrition and short career intentions of junior physiotherapists.OBJECTIVEThis study explored factors associated with physiotherapy graduates' early career intentions and satisfaction.METHODFour cohorts of student physiotherapists completed two online surveys designed specifically for this study assessing their immediate and future career intentions and satisfaction. Surveys were completed after undergraduate training (Student Survey) and 2 years later (Practitioner Survey). Question formats included single or multiple select, Likert scale, and free-text responses. Responses were analyzed via descriptive statistics and content and relational analysis.RESULTSDespite most early career practitioners (83%) reporting career satisfaction, 27% intended to pursue long-term physiotherapy careers (>20 years) and 15% intended to work for 5 years or less. Fewer (11%) reported a longer career intention and 26% a shorter career intention compared to their student survey. Extrinsic occupational factors, such as support, were mentioned as influential in increasing intended future career length since course completion.CONCLUSIONThis study found some evidence of factors contributing to shorter career intentions of early career physiotherapists. Specific support of early career physiotherapists may encourage longer career intentions and help build future workforce capacity.

2024-09-01·Journal of the Academy of Nutrition and Dietetics

Communication Skills: A Scoping Review of Experiences, Perceptions, and Use in Dietetics Practice

Review

作者: Palermo, Claire ; Reedy, Gabriel ; Knight, Annemarie ; Whelan, Kevin

BACKGROUNDCommunication skills are a cornerstone of practice for dietitians. The field of dietetics is evolving and there is a need to synthesize the available literature on communication skills to improve the effectiveness of patient consultations and inform practitioner development.OBJECTIVEThis scoping review aimed to identify the research literature relating to communication skills used in dietetics practice and perceptions and experiences of dietetics students, dietitians, and patients regarding communication skills.METHODSThis scoping review was conducted in accordance with the Joanna Briggs Institute methodology for scoping reviews and best practice guidance. Five databases (Medline, Embase, the Cumulative Index to Nursing and Allied Health Literature, Education Resources Information Center, and PsycInfo), two theses databases, and conference proceedings for 8 dietetics and health professions education associations were systematically searched for research on dietitians' communication skills. This included skills used in dietitian-patient communication, in communication interactions in different employment contexts, and diverse forms of communication (verbal, written, technological) and the views of dietetics students, dietitians, and patients, regarding communication skills. The search had no geographical or time limits. Studies were independently screened by two authors.RESULTSThe 70 included studies spanned 45 years and were organized into four thematic categories: importance of communication skills in dietetics practice, development of communication skills, communication skills for dietitian-patient communication, and communication skills for wider dietetics practice. Sixty-five (92.9%) of the studies specifically explored the communication skills used for dietitian-patient consultations, including rapport building, questioning, listening, paraphrasing, and clarifying, whereas skills such as intercultural communication were less researched.CONCLUSIONSThere is consensus between patients and dietitians regarding the skills that contribute to effective dietitian-patient communication. Areas less explored in the literature include the skills needed for intercultural communication and those needed for science communication. Greater understanding of the communication skills needed for contemporary nutrition and dietetics practice will guide education strategies for the development of dietitians.

2024-05-01·Journal of Biological Chemistry

Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil

Article

作者: Mak, Jeffrey Y W ; Rossjohn, Jamie ; Corbett, Alexandra J ; McCluskey, James ; Le, Jeremy P ; Fairlie, David P ; Ciacchi, Lisa ; Awad, Wael

Mucosal-associated invariant T (MAIT) cells can elicit immune responses against riboflavin-based antigens presented by the evolutionary conserved MHC class I related protein, MR1. While we have an understanding of the structural basis of human MAIT cell receptor (TCR) recognition of human MR1 presenting a variety of ligands, how the semi-invariant mouse MAIT TCR binds mouse MR1-ligand remains unknown. Here, we determine the crystal structures of 2 mouse TRAV1-TRBV13-2⁺ MAIT TCR-MR1-5-OP-RU ternary complexes, whose TCRs differ only in the composition of their CDR3β loops. These mouse MAIT TCRs mediate high affinity interactions with mouse MR1-5-OP-RU and cross-recognize human MR1-5-OP-RU. Similarly, a human MAIT TCR could bind mouse MR1-5-OP-RU with high affinity. This cross-species recognition indicates the evolutionary conserved nature of this MAIT TCR-MR1 axis. Comparing crystal structures of the mouse versus human MAIT TCR-MR1-5-OP-RU complexes provides structural insight into the conserved nature of this MAIT TCR-MR1 interaction and conserved specificity for the microbial antigens, whereby key germline-encoded interactions required for MAIT activation are maintained. This is an important consideration for the development of MAIT cell-based therapeutics that will rely on preclinical mouse models of disease.

100 项与 Monash University, Clayton campus 相关的药物交易

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100 项与 Monash University, Clayton campus 相关的转化医学

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