Visual Quality and Corneal Biomechanical Changes after Laser Treatments for Myopia with or without Astigmatism Using FS-LASIK, SMILE and surface ablation; A Prospective Multicenter Clinical Trial

开始日期2017-05-01

申办/合作机构

温州医科大学附属眼视光医院

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100 项与 University of Pittsburgh School of Dental Medicine 相关的临床结果

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0 项与 University of Pittsburgh School of Dental Medicine 相关的专利（医药）

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6,959

项与 University of Pittsburgh School of Dental Medicine 相关的文献（医药）

2026-04-01·BIOMATERIALS

Intracortical microstimulation induces rapid microglia process convergence

Article

作者: Cui, X Tracy ; Williams, Nathaniel P ; Vazquez, Alberto L ; Zheng, X Sally ; Kelly, Anna M

Intracortical microstimulation (ICMS) has the potential to restore vision and hearing by stimulating relevant cortical regions in both animals and humans, offering significant clinical promise for sensory restoration. While the neuronal response to ICMS has been extensively studied at the cellular level through electrophysiology and two-photon (2P) imaging, the response of non-neuronal cells, particularly microglia, as well as the effects on blood-brain barrier (BBB) integrity remain poorly understood. In this study, we applied ICMS under 2P imaging in dual-reporter mice, with green fluorescent protein labeling microglia and a red fluorescent Ca²⁺ indicator labeling neurons. We also monitored vascular dye leakage to assess BBB integrity. Using clinically relevant waveforms, we tested a range of current amplitudes. Surprisingly, we found that microglia responded within 15 min of stimulation by converging their processes (MPC) on areas of high neural activity and the prevalence of MPC increased at higher current amplitudes. Additionally, vascular dye penetration into brain tissue was higher in stimulated animals and increased with current amplitude. This study reveals a rapid microglia and BBB response to ICMS that has not been reported previously, underscoring the need for further research to fully characterize the biological response to ICMS and establish improved safety standards.

2026-03-01·PATTERN RECOGNITION

Medical image segmentation using dual-decoder mutual teaching with a mean teacher framework

Article

作者: Wang, Lei ; Chen, Hao ; Zhang, Juan ; Yu, Qingxiang ; Yi, Quanyong ; Jiang, Gaoqiang ; Li, Zhongwen ; Tian, Bihan ; Pu, Jiantao ; Zhou, Jie ; Yu, Shuchen

Accurate segmentation of medical images is essential for many clinical applications and is now typically achieved by training deep learning models on large annotated datasets. However, acquiring sufficient labeled images remains challenging, as pixel-level manual annotations are highly time-consuming. To substantially reduce the manual effort, we developed a novel semi-supervised segmentation method, termed dual-decoder mutual teaching (DDMT), which incorporates a smoothed exponential moving average (sEMA) scheme and a shape consistency constraint (SCC) scheme into the classical mean teacher (MT) framework. The sEMA scheme enhances the stability of the student and teacher models during training, while the SCC scheme ensures consistent learning of shape characteristics across the two different decoders within each model. With these two innovative components, DDMT achieves promising segmentation performance when trained on limited labeled images and abundant unlabeled images. Experiments on public datasets for left atrium, pancreas, and optic disc segmentation demonstrated that DDMT consistently outperforms several state-of-the-art semi-supervised learning (SSL) methods (e.g., MT, UAMT, DTC, and MCNet) across varying proportions of labeled images. The source code is publicly available at https://github.com/wmuLei/ddmt.

2026-02-01·JOURNAL OF AFFECTIVE DISORDERS

Dont cry, sweetheart: Moment-to-moment responses to toddler negative affect for mothers with and without depression

Article

作者: Morgan, Judith K ; Griffith, Julianne ; Hendricks, Zachary ; Taraban, Lindsay ; Forbes, Erika E

Depression is common among mothers of young children and has documented impacts on the parent-child relationship and children's emotional development. Examining in-the-moment maternal responses to toddlers' expressions of negative affect can inform our understanding of the specific ways depression may impact mother-child interaction. Among a sample (n = 131) of mothers (44.3 % clinically depressed) and their 1- to 3-year-old children, we examined maternal response to toddler expression of negative affect during a series of interactive tasks. We looked across the spectrum of maternal responses to child negative affect, including responding with comforting behavior, positive affect, neutral affect, and negative affect, and how this differed between mothers with and without depression. Consistent with hypotheses, we found that mothers with depression were less likely to display positive affect and more likely to display neutral affect in the epoch following child negative emotional expression, compared to mothers without depression. Contrary to hypotheses, we found that mothers with depression were similarly likely as mothers without depression to respond to child negative affect with comforting behavior and negative affect themselves. As caregiver response to toddler negative affect shapes the development of early child emotional regulation abilities, better understanding specific patterns of maternal emotional responsiveness to toddler's negative affect can support effective intervention with mothers to help them build their child's emotion regulation abilities, even in the context of maternal depression.

项与 University of Pittsburgh School of Dental Medicine 相关的新闻（医药）

2024-12-23

·PRNewswire

Penn Dental Medicine Pain Management Clinical Practice Guideline Among Top Trending Articles in 2024

PHILADELPHIA, Dec. 23, 2024 /PRNewswire/ -- A pain management clinical practice guideline developed by Penn Dental Medicine's Center for Integrative Global Oral Health (CIGOH) is among The Journal of the American Dental Association (JADA)'s top five trending articles for 2024, according to JADA. Originally published in the September 2023 issue of JADA, the guideline for managing acute dental pain in children was developed by CIGOH, the American Dental Association Science and Research Institute (ADASRI), and the University of Pittsburgh School of Dental Medicine. Dr. Alonso Carrasco-Labra, Associate Professor and Director of the Cochrane Oral Health Collaborating Center at Penn Dental Medicine, and Olivia Urquhart, an epidemiologist and instructor within CIGOH, co-led its development. Endorsed by the ADA, the guideline notes that acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are recommended as first-line treatments for managing short-term dental pain in children under age 12. A guideline panel determined that, when used as directed, acetaminophen alone, NSAIDs (like ibuprofen) alone or acetaminophen in combination with NSAIDS can effectively manage a child's pain after a tooth extraction or during a toothache when dental care is not immediately available. According to the guideline, when acetaminophen or NSAIDs are administered as directed by a dentist or other health care provider, the risk of harm to children from either medication is low. These recommendations align with previous guidance from the U.S. Food and Drug Administration (FDA) in 2017, which contraindicated the use of codeine and tramadol in children under age 12. In 2020, the FDA awarded the University of Pittsburgh and ADASRI a $1.5 million grant to develop a clinical practice guideline for the management of acute pain in dentistry in children, adolescents and adults. A group of researchers and methodologists from ADASRI, the University of Pittsburgh School of Dental Medicine, CIGOH, McMaster University and the Art of Democracy worked together to develop this pediatric patient guideline as well as one for adolescents, adults, and older adults, which published in February 2024. Both guidelines can be found at ada.org/painmanagement. Contact: Beth Adams, [email protected] SOURCE PENN DENTAL MEDICINE WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

2024-12-03

·PRNewswire

The National Hispanic Health Foundation (NHHF) Hosts Scholarship Gala in Washington, DC to Honor Leaders and Students Advancing Health Equity

WASHINGTON, Dec. 3, 2024 /PRNewswire/ -- The National Hispanic Health Foundation (NHHF) is proud to announce the awarding of 18 new scholarships with the support of the United Health Foundation (up to $20,000) to graduate students from the Western United States on their journeys to become doctors, nurses, dentists, pharmacists, and physician assistants in our communities. "We are deeply grateful to our leaders and sponsors whose support strengthens the path toward a more diverse and equitable health sector," said Dr. Elena Rios, President of NHHF. The Washington DC Awards Gala will be held on December 4th from 6:30-10:30 p.m. Eastern Time at the Hilton Washington DC, National Mall, The Wharf. The National Hispanic Health Foundation thanks the following health leaders for their work in transforming government programs, academic institutions, private sector organizations, and local communities to increase access to health care. Washington DC Hispanic Health Leadership Honorees include: Congresswoman Nanette Barragán; Congressman Adriano Espaillat; Congressman Joaquin Castro; Congresswoman Linda T. Sánchez; David J. Skorton, MD (President & CEO of the Association of American Medical Colleges); Cristina Antelo (CEO of Feroz Strategies); and Sindy Escobar Alvarez, PhD, (Medical Research Program Director at the Doris Duke Foundation). With immense gratitude, NHHF thanks all our scholarship gala sponsors across sectors for their generosity and dedication to supporting our mission to empower and diversify the next generation of health professionals. Platinum Sponsors include: United Health Foundation. Gold Sponsors include: Centene Corporation. Silver Sponsors include: Bristol-Myers Squibb-Pfizer Alliance, Eli Lilly, Otsuka Pharmaceuticals. Media Partners include: El Tiempo Latino, Latina Publishers, Latina Style Magazine, Latino Leaders, and Rolli. It is with great pleasure that the National Hispanic Health Foundation announces the following 2024 scholarship award recipients for the Eastern United States: Natalia Perez Baez University of Illinois College of Medicine Jhoely Duque-Jimenez Weill Cornell Medical College Angela Teresa Perez Villalobos Georgetown University School of Medicine Elyse Manzo Martin Tufts University School of Medicine Yanilka Rodriguez SUNY Downstate Health Sciences University College Devin Barzallo Case Western Reserve University of Medicine Dariana Gil Hernandez Yale University School of Medicine Ronald Arguete Howard University College of Medicine Jessica Schlaen Nova Southern University College of Dental Medicine Margarita Nino University of Pittsburgh School of Dental Medicine Adele Shepin Saint Elizabeth University Physician Associate School Maria C Arevalo City of University of New York School of Medicine Physician Associate Melanie Kapelson Rivier University School of Nursing and Health Professions Eliam Aguilar Rollero University of Puerto Rico- Medical Sciences Campus Angela Gates Virginia Commonwealth University School of Pharmacy Megan Rebollar Mercer University College of Pharmacy Bernardo Lopez Samayoa Johns Hopkins Bloomberg School of Public Health Sebastian Cota Columbia University Mailman School of Public Health Visit nhhfx.org for additional information about the gala and NHHF SOURCE National Hispanic Health Foundation WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

2024-03-13

·PRNewswire

New Practice Guideline Co-Led by Penn Dental Medicine Details Dental Pain Management Strategies

PHILADELPHIA, March 13, 2024 /PRNewswire/ -- A new clinical practice guideline for managing acute dental pain in adolescents and adults has been released, recommending nonsteroidal anti-inflammatory drugs (NSAIDs) taken alone or with acetaminophen as first-line treatments for managing short-term dental pain. The guideline was developed by Penn Dental Medicine's Center for Integrative Global Oral Health (CIGOH), the American Dental Association (ADA), and the University of Pittsburgh School of Dental Medicine. Dr. Alonso Carrasco-Labra, Associate Professor and Director of the Cochrane Oral Health Collaborating Center at Penn Dental Medicine, and Olivia Urquhart, an epidemiologist and instructor within CIGOH, co-led its development. Published in the February 2024 issue of JADA, the guideline has been endorsed by the ADA. Based on a review of the best available evidence, the guideline panel concluded that, when used as directed, NSAIDs like ibuprofen and naproxen alone or in combination with acetaminophen can effectively manage pain after having a tooth removed or when experiencing a toothache when dental care is not immediately available. "The recommended approach is to use nonopioid analgesics as the primary treatment instead of opioid analgesics," says Carrasco-Labra. "This is due to their effectiveness and lower risk profile." The guideline also offers clinicians recommendations for prescribing opioid medications in the limited circumstances in which they may be appropriate. These include avoiding "just in case" prescriptions, engaging patients in shared decision-making, and exerting extreme caution when prescribing opioids to adolescents and young adults. When prescribing opioids, the guideline suggests advising patients on proper storage and disposal and considering any risk factors for opioid misuse and serious adverse events. "Clinicians are encouraged to have conversations with their patients where they inform them to anticipate some level of discomfort and explain what it will feel like," adds Carrasco-Labra. "The prescribed analgesics should make the pain manageable but also align with what the patient seeks in terms of associated risks. If they're coming in for a procedure that will likely result in some mild discomfort, they need to be in the driver's seat in determining the appropriate pain-management strategy." This is the second of two guidelines on acute dental pain management from this research team. A previous set of recommendations for pediatric patients was published in 2023. Both guidelines are can be found at ada.org/painmanagement. Read more on takeaways from the guideline » Contact: Beth Adams [email protected] SOURCE PENN DENTAL MEDICINE

100 项与 University of Pittsburgh School of Dental Medicine 相关的药物交易

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100 项与 University of Pittsburgh School of Dental Medicine 相关的转化医学

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