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项与 Immuno-Biological Laboratories Co., Ltd. 相关的文献（医药）

2024-04-01·Journal of Lipid Research

Quantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay

Article

作者: Ogura, Kazumi ; Ploug, Michael ; Tsunekawa, Katsuhiko ; Young, Stephen G ; Yokoyama, Erina ; Kimura, Takao ; Fukamachi, Kumiko ; Miyashita, Kazuya ; Yang, Ye ; Fukamachi, Isamu ; Nagasawa, Takumi ; Murakami, Masami ; Song, Wenxin ; Nakajima, Katsuyuki ; Beigneux, Anne P

To support in vivo and in vitro studies of intravascular triglyceride metabolism in mice, we created rat monoclonal antibodies (mAbs) against mouse LPL. Two mAbs, mAbs 23A1 and 31A5, were used to develop a sandwich ELISA for mouse LPL. The detection of mouse LPL by the ELISA was linear in concentrations ranging from 0.31 ng/ml to 20 ng/ml. The sensitivity of the ELISA made it possible to quantify LPL in serum and in both pre-heparin and post-heparin plasma samples (including in grossly lipemic samples). LPL mass and activity levels in the post-heparin plasma were lower in Gpihbp1^-/- mice than in wild-type mice. In both groups of mice, LPL mass and activity levels were positively correlated. Our mAb-based sandwich ELISA for mouse LPL will be useful for any investigator who uses mouse models to study LPL-mediated intravascular lipolysis.

2023-12-06·Journal of Alzheimer's Disease

Clinical Evaluation of Cerebrospinal Fluid p217tau and Neurofilament Light Chain Levels in Patients with Alzheimer’s Disease or Other Neurological Diseases

Article

作者: Kasahara, Hiroo ; Segawa, Tatsuya ; Ishizawa, Kunihiko ; Oka, Hironori ; Kawarabayashi, Takeshi ; Nakamura, Takumi ; Miyashita, Kazuya ; Shoji, Mikio ; Sugawara, Takashi ; Fukamachi, Isamu ; Ikeda, Yoshio ; Takatama, Masamitsu ; Amari, Masakuni ; Makioka, Kouki

Background: The cerebrospinal fluid (CSF) levels of tau phosphorylated at threonine 217 (p217tau) or 181 (p181tau), and neurofilament light chain (NfL) are definite biomarkers of tauopathy and neurodegeneration in Alzheimer’s disease (AD). Objective: To validate their utility in excluding other neurological diseases and age-related changes in clinical settings. Methods: We developed monoclonal antibodies against p217tau and NfL, established novel ELISAs, and analyzed 170 CSF samples from patients with AD or other neurological diseases. Results: In AD, p217tau is a more specific and abundant CSF component than p181tau. However, CSF NfL levels increase age-dependently and to a greater extent in central and peripheral nervous diseases than in AD. Conclusions: CSF p217tau correlates better with AD neurodegeneration than other tau-related biomarkers and the major phosphorylated tau species. The clinical usage of NfL as a neurodegeneration biomarker in AD requires exclusion of various central and peripheral neurological diseases.

2023-08-01·Journal of Atherosclerosis and Thrombosis

Two Cases of Acquired High-Density Lipoprotein Deficiency with Immunoglobulin G4-Related Lecithin–Cholesterol Acyltransferase Autoantibody

Article

作者: Uehara, Yoshinari ; Komatsu, Tomohiro ; Kuwata, Koji ; Endo, Yasuhiro ; Miyashita, Kazuya ; Sasaki, Kei ; Teramoto, Manami ; Ikewaki, Katsunori ; Katsurada, Yuka ; Matsukuma, Susumu ; Hirano, Tsutomu ; Abe, Satomi ; Sakurada, Masami ; Imakiire, Toshihiko ; Nishida, Takafumi ; Miyake, Takayuki ; Sasaki, Makoto ; Suzuki, Natsuko ; Arakawa, Junko

Lecithin-cholesterol acyltransferase (LCAT) plays a significant role in the progression from premature to mature high-density lipoprotein (HDL) in circulation. Consequently, primary or secondary LCAT deletion or reduction naturally results in low serum HDL cholesterol levels. Recently, rare cases of acquired HDL deficiency with LCAT autoantibodies have been reported, mainly from Japan, where LCAT autoantibodies of immunoglobulin G (IgG) caused the HDL deficiency. Here to our knowledge, we report for the first time two cases of acquired HDL deficiency caused by IgG4 linked LCAT autoantibodies with or without a high serum IgG4 level. Furthermore, these cases can extend to a new concept of "IgG4 autoimmune disease" from the viewpoint of verifying the serum autoantibody and/or renal histopathology.

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