预约演示

更新于：2025-01-23

FCGR1BP

更新于：2025-01-23

基本信息

别名

CD64b、Fc gamma receptor IB pseudogene、Fc gamma receptor Ib, pseudogene

+ [9]

简介

May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.

关联

项与 FCGR1BP 相关的药物

CN114524878

专利挖掘

靶点

FCGR1BP x FcγR

作用机制-

在研机构

康诺亚生物医药科技（成都）有限公司

原研机构

康诺亚生物医药科技（成都）有限公司

在研适应症

血液疾病 [+3]

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 FCGR1BP 相关的临床结果

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100 项与 FCGR1BP 相关的转化医学

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0 项与 FCGR1BP 相关的专利（医药）

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106

项与 FCGR1BP 相关的文献（医药）

2024-11-01·Science of The Total Environment

MPs and PFOS single and combined exposure significantly alter genetic expressions of growth hormone and insulin growth factor-related biomarkers during zebrafish embryonic development

Article

作者: Junaid, Muhammad ; Xie, Shaolin ; Tang, Huijuan ; Shu, Qingsong ; Zheng, Ran ; Zou, Jixing ; Zhou, Aiguo

Microplastics (MPs) and perfluorooctane sulfonate (PFOS) are emerging pollutants that are ubiquitously present in the environment and can cause series of ecotoxicological effects on aquatic animals. This study examined how the expression of genes related to insulin growth factor (igf1, igf2a, igf2b, igfra, and igfrb) and growth hormone (ghrh, gh1, ghra, and ghrb) changes during the development of zebrafish embryos exposed to 8 μm polyethylene microplastics (PE-MPs) and perfluorooctane sulfonate (PFOS) individually and in combination for 72 h. Our findings revealed that both low-concentrations of MP (50 μg/L) and PFOS (0.02 μg/L) treatments could significantly activate gene expression within a short period. High concentrations of MPs (500 μg/L) and PFOS (0.1 μg/L) not only rapidly activated gene expression but also sustained high expression levels for a longer duration. During combined exposures, peak gene expression in the low concentration groups (50 μg/L MPs and 0.02 μg/L PFOS; 50 μg/L MPs and 0.1 μg/L PFOS) primarily occurred within 12 h after treatment. In the high concentration groups (500 μg/L MPs and 0.02 μg/L PFOS), peak expression was also observed within 12 h. Notably, the combined exposure groups exhibited more pronounced effects on gene expression than the individual exposure groups. The activation of gene expression was both more significant and longer-lasting in the combined exposure, indicating a synergistic regulatory effect of MPs and PFOS. Overall, our study suggests that zebrafish embryo development can be significantly impacted by exposure to MPs, PFOS, and their combination, with combined exposures having a more lasting and profound effect on gene regulation compared to single exposures.

2024-06-01·Herz

Novel biomarkers identified by weighted gene co-expression network analysis for atherosclerosis

Article

作者: Xu, Jialin ; Huang, Kaijian ; Lu, Qi ; Chen, Chu ; Ni, Jiajun

BACKGROUNDThis study aimed to screen out the potential diagnostic biomarkers for atherosclerosis (AS).METHODSWe downloaded the gene expression profiles GSE66360, GSE28829, GSE41571, GSE71226, and GSE100927 from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were identified using the "limma" package in R. Weighted gene co-expression network analysis (WGCNA) was applied to reveal the correlation between genes in different samples. Subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. The interaction pairs of proteins were retained by the STRING database, and the protein-protein interaction (PPI) network was visualized with the hub genes. Finally, the R packages "ggpubr" and "preprocessCore" were used to analyze immune cell infiltration.RESULTSIn total, 40 overlapping genes both in GSE66360 and GSE28829 were found to be related to the occurrence of AS. Further, the top 10 network hub genes including TYROBP, CSF1R, TLR2, CD14, CCL4, FCER1G, CD163, TREM1, PLEK, and C5AR1 were identified as significant key genes. Moreover, four genes (TYROBP, CSF1R, FCGR1B, and CD14) were verified that could efficiently diagnose AS. Finally, the gene TYROBP was found to have a strong correlation with immune-infiltrating cells.CONCLUSIONOur study identified four genes (TYROBP, CSF1R, FCGR1B, and CD14) that may be effective biomarkers for AS, with the potential to guide the clinical diagnosis of AS.

2023-12-01·Tuberculosis

Type I interferons and Mycobacterium tuberculosis whole cell lysate induce distinct transcriptional responses in M. tuberculosis infection

Article

作者: Mutua, Florence ; Ball, T Blake ; Kiazyk, Sandra ; Lopez, Carmen ; Su, Ruey-Chyi ; Mesa, Christine

Type I interferon (IFN)-induced genes have the potential for distinguishing active tuberculosis (ATB) from latent TB infection (LTBI) and healthy controls (HC), monitoring treatment, and detection of individuals at risk of progression to active disease. We examined the differential effects of IFN-α, IFN-β and Mycobacterium tuberculosis whole cell lysate (Mtb WCL) stimulation on the expression of selected IFN-stimulated genes in peripheral blood mononuclear cells from individuals with either LTBI, ATB, and healthy controls. Stimulation with IFN-α and IFN-β induced a higher expression of the interrogated genes while Mtb WCL stimulation induced expression similar to that observed at baseline, with the exception of IL-1A and IL-1B genes that were downregulated. The expression of IFN-α-induced FCGR1A gene, IFN-β-induced FCGR1A, FCGR1B, and SOCS3 genes, and Mtb WCL-induced IFI44, IFI44L, IFIT1, and IFITM3 genes differed significantly between LTBI and ATB. These findings suggest stimulation-driven gene expression patterns could potentially discriminate LTBI and ATB. Mechanistic studies are necessary to define the processes through which distinct type I IFNs and downstream ISGs determine infection outcomes and identify potential host-directed therapeutic strategies.

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