别名 CCN family member 1、CCN1、cellular communication network factor 1 + [10] |
简介 Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
作用机制 CCN1 stimulators [+3] |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症- |
最高研发阶段药物发现 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
作用机制 CCN1 modulators [+1] |
在研机构- |
在研适应症- |
非在研适应症- |
最高研发阶段无进展 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2024-04-08 |
申办/合作机构- |
开始日期2023-11-15 |
申办/合作机构- |
开始日期2022-08-16 |