更新于：2024-11-01

MPXV A29L

更新于：2024-11-01

基本信息

别名-

简介-

关联

项与 MPXV A29L 相关的药物

mRNA-A-LNP(Chinese PLA Academy of Military Medical Sciences)

靶点

MPXV A29L x MPXV A35R x MPXV B6R x MPXV M1R

作用机制

MPXV A29L抑制剂 [+3]

在研机构

中国人民解放军军事医学科学院

原研机构

中国人民解放军军事医学科学院

在研适应症

病毒感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

mRNA-B-LNP(Chinese PLA Academy of Military Medical Sciences)

靶点

MPXV A29L x MPXV A35R x MPXV B6R x MPXV M1R

作用机制

MPXV A29L抑制剂 [+3]

在研机构

中国人民解放军军事医学科学院

原研机构

中国人民解放军军事医学科学院

在研适应症

病毒感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 MPXV A29L 相关的临床结果

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100 项与 MPXV A29L 相关的转化医学

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0 项与 MPXV A29L 相关的专利（医药）

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项与 MPXV A29L 相关的文献（医药）

2024-10-12·Journal of Biomolecular Structure and Dynamics

Supervised screening of Tecovirimat-like compounds as potential inhibitors for the monkeypox virus E8L protein

Article

作者: Jia, Guihua ; Nawab, Sadia ; Kaushik, Aman Chandra ; Mehmood, Aamir ; Wei, Dong-Qing

Monkeypox virus (MPXV) is a budding public health threat worldwide, and there lacks a personalized drug availability to treat MPXV infections. Tecovirimat, an antiviral drug against pox viruses, is recently confirmed to be effective against the MPXV in vitro using nanomolar concentrations. Therefore, the current study considers Tecovirimat as a reference compound for a machine learning-based guided screening to scan bioactive compounds from the DrugBank with similar chemical features or moieties as the Tecovirimat to inhibit the MPXV E8L surface binding protein. We used AlphaFold2 to model the E8L's 3D structure, followed by the conformational activity investigation of shortlisted drugs through computational structural biology approaches, including molecular docking and molecular dynamics simulations. As a result, we have shortlisted five drugs named ABX-1431, Alflutinib, Avacopan, Caspitant, and Darapalib that effectively engage the MPXV surface binding protein. Furthermore, the affinity of the proposed drugs is relatively higher than the Tecovirimat by having higher docking scores, establishing more hydrogen and hydrophobic bonds, engaging key residues in the target's structure, and exhibiting stable molecular dynamics.Communicated by Ramaswamy H. Sarma.

2024-04-01·Journal of Colloid and Interface Science

Fabrication of label-free immunoprobe for monkeypox A29 detection using one-step electrodeposited molybdenum oxide-graphene quantum rods

Article

作者: Kumar Arumugasamy, Shiva ; Chellasamy, Gayathri ; Yun, Kyusik ; Dhanasekaran, Barkavi ; Veerapandian, Mekala ; Chandran, Murugesan ; Govindaraju, Saravanan

Monkeypox is a zoonotic viral infection caused by the monkeypox virus (MPXV), which belongs to the Poxviridae family of the Orthopoxvirus (OPXV) genus. Monkeypox is transmitted from animals to humans and humans to humans; therefore, the accurate and early detection of MPXV is crucial for reducing mortality. A novel graphene-based material, graphene quantum rods (GQRs) was synthesized and confirmed using high-resolution transmission electron microscopy (HR-TEM) and atomic force microscopy (AFM). In this study, molybdenum oxide was electrodeposited and one-pot electrodeposition of MoO₃-GQRs composite on carbon fiber paper (CFP) enabled by an antibody (Ab A29)/MoO₃-GQRs immunoprobe was developed for the early diagnosis of MPXV protein (A29P). Several studies were conducted to analyze the MoO₃-GQRs composite, and the prepared Ab A29/MoO₃-GQRs immunoprobe selectively bound to the A29P antigen that was measured using differential pulse voltammetry (DPV) analysis and impedance spectroscopy. The antigen-antibody interaction was analyzed using X-ray photoelectron spectroscopy. DPV analysis showed a wide linear range of detection from 0.5 nM to 1000 nM, a detection limit of 0.52 nM, and a sensitivity of 4.51 µA in PBS. The prepared immunoprobe was used to analyze A29P in serum samples without reducing electrode sensitivity. This system is promising for the clinical analysis of A29P antigen and offers several advantages, including cost-effectiveness, ease of use, accuracy, and high sensitivity.

Analytical Methods

CRISPR/Cas12a-mediated ultrasensitive and on-site monkeypox viral testing

Article