更新于：2024-09-19

HNRNPC

更新于：2024-09-19

基本信息

别名

heterogeneous nuclear ribonucleoprotein C、Heterogeneous nuclear ribonucleoproteins C1/C2、hnRNP C1/C2

+ [2]

简介

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

关联

100 项与 HNRNPC 相关的临床结果

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100 项与 HNRNPC 相关的转化医学

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0 项与 HNRNPC 相关的专利（医药）

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362

项与 HNRNPC 相关的文献（医药）

2024-11-01·Translational Oncology

LncRNA LINC00173 inhibits the development of endometrial cancer by interacting with HNRNPC

Article

作者: Zhu, Zhijuan ; Yu, Juan ; Du, Rong

BACKGROUNDPrevious research has elaborated on the role of long non-coding RNA LINC00173 in the pathogenesis of various cancers; however, our knowledge of its clinical consequences and mechanisms in endometrial cancer (EC) is limited. Our current work is aimed at investigating the effect of LINC00173 in combination with its upstream gene HNRNPC on EC progression.METHODSLINC00173 and HNRNPC levels were investigated by qRT-PCR or western blotting in EC tissues. The functional roles of HNRNPC and LINC00173 were assessed using transwell, colony formation and CCK-8 assays. A xenograft was used to verify the phenotype of LINC00173 after its overexpression. The regulatory role between HNRNPC and LINC00173 was investigated using RIP and RNA pull-down analysis.RESULTSIn EC tissues, LINC00173 expression was down-regulated. We observed that increased LINC00173 inhibited EC cell growth and migration. LINC00173 was a downstream target of HNRNPC, and its expression level was elevated by HNRNPC silencing. LINC00173 overexpression shifted part of HNRNPC into the cytoplasm from the nucleus of EC cells. Furthermore, HNRNPC expression was upregulated in EC and its silencing inhibited EC cell malignancy in vitro.CONCLUSIONLINC00173 can impair the malignancy of EC cell by interacting with HNRNPC. This finding may contribute to the understanding of the tumorigenic effects of HNRNPC and LINC00173 on EC.

2024-10-01·Insect Biochemistry and Molecular Biology

JAK and STAT5B mediate olfactory response of migratory locusts to their own volatiles

Article

作者: Zhang, Lichen ; Ma, Zongyuan ; Liu, Jipeng

Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling affect social aggregation, mood and psychiatric disorders, nociceptive and depressive behaviors. Olfactory dysfunction is one of the distinct symptoms of these behaviors, but function and mechanism of JAK and STAT in modulating olfaction remain largely unknown. Migratory locusts show olfactory preference for their own volatiles. We thus use this animal model to explore functions and mechanisms of JAK and STAT5B in mediating olfaction response to their own volatiles. Tissue distribution study shows that JAK and STAT5B express in antennae and brains, especially in antennal lobes and mushroom bodies in locust brains, and knockdown of these two genes by RNA interference (RNAi) in antennae and brains results in the loss of olfactory preference for locust volatiles, including chemical odorants indole and β-ionone. RNA-seq analysis reveals that JAK and STAT5B RNAi knockdown downregulates a functional class of transcripts in nucleoprotein complex, including heterogeneous nuclear ribonucleoprotein C (hnRNPC) and small nuclear ribonucleoprotein polypeptide F (SNRPF). HnRNPC and SNRPF mRNAs and proteins are also expressed in antennae and brains, and RNAi knockdown of these two genes reduces the percentage of locusts preferring volatiles, including chemical odorants indole and β-ionone. Furthermore, RNAi knockdown of dopamine receptor 1 (DopR1) results in the decrease of JAK mRNA level in antennae, and JAK/STAT5B, hnRNPC and SNRPF are required for dopamine receptor 1 (DopR1) to modulate olfactory preference for their own volatiles. This study confirms that JAK/STAT5B signaling modulates olfaction by affecting expression levels of hnRNPC and SNRPF, and this pathway is also required for DopR1 to modulate olfactory preference for their own volatiles. These findings highlight novel roles of JAK and STAT5B in modulating olfactory preference. This study provides novel insights into functional links among JAK/STAT5B signaling, RNA binding proteins and DopR1 underlying the modulation of olfactory behaviors.

2024-08-01·Annals of Hematology

A HNRNPC::RARB variant of acute promyelocytic leukemia with concurrent myeloid sarcoma of the spine

Letter

作者: Wang, Aixian ; Wang, Hui ; Wu, Ping ; Fu, Minjing ; Chen, Man ; Li, Ting

项与 HNRNPC 相关的新闻（医药）

2023-09-13

·生物探索

阻断髓性白血病分化的新策略

N6-甲基腺苷(m6A)甲基化可通过RNA甲基转移酶复合物(MTC)沉积在染色质相关RNA (caRNAs)上，调控染色质状态和转录。然而，MTC被募集到不同基因组位点的机制仍然难以捉摸。2023年8月28日，芝加哥大学何川、陈梦洁及贝克曼研究中心陈建军共同通讯在Nature Cell Biology 在线发表题为“RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation”的研究论文，该研究发现RBFOX2识别N6-甲基腺苷抑制转录，阻断髓性白血病分化。RBFOX2可以募集MTC成分RBM15，促进启动子相关RNA的甲基化。RBM15也与YTHDC1物理相互作用，将多梳抑制复合体2 (PRC2)募集到RBFOX2结合的位点，从而实现染色质沉默和转录抑制。此外，作者发现RBFOX2/m6A/RBM15/YTHDC1/PRC2轴在髓性白血病中起关键作用。下调RBFOX2显著抑制急性髓系白血病细胞的存活/增殖，促进其髓系分化。RBFOX2也是白血病干细胞/起始细胞自我更新和急性髓性白血病维持所必需的。该研究提出了m6AMTC募集和m6A沉积在caRNAs上的途径，导致位点选择性染色质调节，这对白血病具有潜在的治疗意义。m6A是哺乳动物细胞中最常见的信使RNAs。由m6A甲基转移酶复合物(MTC)安装，由METTL3/14、WTAP7、RBM15/15B8、ZC3H13和VIRMA (KIAA1429)组成，并且可以被去甲基化酶FTO11和ALKBH5去除。m6A对mRNA代谢和翻译的功能影响是通过m6A阅读蛋白介导的，例如含有YTH结构域的蛋白(YTHDC1/2)、YTHDF1/2/3。可以通过直接或间接机制优先结合m6A修饰转录本的阅读器蛋白列表，包括IGF2BP1/2/3、HNRNPA2B1、HNRNPC和HuR，还在继续扩大。虽然m6A在转录后mRNA衰变和翻译调控中的关键作用已经得到了很好的证实，但最近的研究也表明，METTL3/METTL14复合体可以介导非编码染色质相关RNAs (caRNAs)的m6A甲基化，从而调节染色质状态并调控转录；然而，MTC如何被募集到不同的染色质位点以及它如何实现位点选择调控在很大程度上是未知的。此外，YTHDC1是唯一被鉴定的m6A与染色质调控相连接的阅读蛋白。然而，如何募集YTHDC1参与m6A依赖性的位点选择性调控尚不清楚。机理模式图（图源自Nature Cell Biology）该研究展示了一个涉及MTC、YTHDC1和RNA结合蛋白(RBP) RBFOX2的转录调控轴：RBFOX2募集MTC成分RBM15来甲基化启动子相关RNAs (paRNAs)。RBM15进一步与YTHDC1相互作用，将PRC2募集到RBFOX2结合的位点进行转录抑制。RBFOX2/ m6A/RBM15/YTHDC1/PRC2轴在髓性白血病中发挥重要作用，下调RBFOX2可显著抑制急性髓性白血病(AML)细胞的存活/增殖，促进AML细胞向髓性分化。因此，RBFOX2被认为是一种染色质因子，在位点特异性染色质调节过程中促进m6A沉积在caRNAs上，具有治疗白血病的意义。综上，该研究揭示了RBFOX2作为染色质上的m6A结合蛋白在促进caRNA甲基化以抑制转录方面的功能作用。这种调控模式填补了染色质和caRNAs的m6A甲基化之间的串扰中一个关键的缺失环节。文章来源“iNture”责编|文竞择校对|文竞择End往期精选围观历史性突破！不需卵子和精子就可以合成人类胚胎热文富豪用儿子血浆“回春”科学吗？Science：血液牛磺酸缺乏驱动衰老热文世界首例！35岁的她，通过机器人操刀移植的子宫，成功诞下宝宝热文为了避免心脏骤停，53岁的他成为“第一个”植入开创性除颤器的心脏病患者热文首次披露！175家生物制药公司的薪资数据：薪资中位数达20万美元点击“阅读原文”，了解更多~

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