更新于：2024-09-19

C16orf72

更新于：2024-09-19

基本信息

别名

C16orf72、chromosome 16 open reading frame 72、FLJ41272

+ [3]

简介

Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365).

关联

100 项与 C16orf72 相关的临床结果

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100 项与 C16orf72 相关的转化医学

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0 项与 C16orf72 相关的专利（医药）

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项与 C16orf72 相关的文献（医药）

2024-08-01·Plant Biology

Genome‐wide analysis of salicylic acid and jasmonic acid signalling marker gene families in wheat

Article

作者: Perochon, A ; Doohan, F M ; Heckmann, A

Abstract

Jasmonic acid (JA) and salicylic acid (SA) phytohormone pathways are important regulators of stress tolerance. Knowledge regarding the diversity, phylogeny and functionality of wheat genes involved in JA and SA response is limited.

Using Arabidopsis, rice and wheat genomic and wheat disease transcriptomic data, we deduced the size, phylogenetic diversity and pathogen‐responsiveness of seven hormone‐responsive gene families, and thus selected 14 candidates as potential hormone responsive gene markers. Gene‐specific expression studies assessed the impact of exogenous JA and SA on their transcriptional activation in leaves of two distinct wheat cultivars. RNAseq data were interrogated to assess their disease responsiveness and tissue‐specific expression.

This study elucidated the number, phylogeny and pathogen‐responsiveness of wheat genes from seven families, including 12 TaAOS, 6 TaJAMyb, 256 TaWRKY group III, 85 TaPR1, 205 TaPR2, 76 TaPR3 and 124 TaPR5. This included the first description of the wheat AOS, JAMyb, PR2, PR3 and PR5 gene families. Gene expression studies delineated TaAOS1‐5B and TaJAMyb‐4A as JA‐responsive in leaves, but not significantly responsive to SA treatment, while TaWRKY45‐B was a SA‐ but not a JA‐responsive marker. Other candidate genes were either unresponsive or non‐specific to SA or JA.

Our findings highlight that all seven gene families are greatly expanded in wheat as compared to other plants (up to 7.6‐fold expansion), and demonstrate disparity in the response to biotic stress between some homoeologous and paralogous sequences within these families. The SA‐ and JA‐responsive marker genes identified herein will prove useful tools to monitor these signalling pathways in wheat.

2024-05-01·Archives of Microbiology

Co-expression network analysis and identification of core genes in the interaction between wheat and Puccinia striiformis f. sp. tritici

Article

作者: Liu, Kai ; Wang, Yibo ; Chen, Wei ; He, Fei ; Zhang, Ke ; Luo, Qiaoling ; Tong, Zhijun ; Chen, Dan

The epidemic of stripe rust, caused by the pathogen Puccinia striiformis f. sp. tritici (Pst), would reduce wheat (Triticum aestivum) yields seriously. Traditional experimental methods are difficult to discover the interaction between wheat and Pst. Multi-omics data analysis provides a new idea for efficiently mining the interactions between host and pathogen. We used 140 wheat-Pst RNA-Seq data to screen for differentially expressed genes (DEGs) between low susceptibility and high susceptibility samples, and carried out Gene Ontology (GO) enrichment analysis. Based on this, we constructed a gene co-expression network, identified the core genes and interacted gene pairs from the conservative modules. Finally, we checked the distribution of Nucleotide-binding and leucine-rich repeat (NLR) genes in the co-expression network and drew the wheat NLR gene co-expression network. In order to provide accessible information for related researchers, we built a web-based visualization platform to display the data. Based on the analysis, we found that resistance-related genes such as TaPR1, TaWRKY18 and HSP70 were highly expressed in the network. They were likely to be involved in the biological processes of Pst infecting wheat. This study can assist scholars in conducting studies on the pathogenesis and help to advance the investigation of wheat-Pst interaction patterns.

2023-12-01·Molecular Plant Pathology

The interaction of two Puccinia striiformis f. sp. tritici effectors modulates high‐temperature seedling‐plant resistance in wheat

Article

作者: Shang, Hongsheng ; Hu, Xiaoping ; Chen, Xianming ; Bao, Xiyue ; Li, Yuxiang ; Hu, Yangshan

AbstractWheat cultivar Xiaoyan 6 (XY6) has high‐temperature seedling‐plant (HTSP) resistance to Puccinia striiformis f. sp. tritici (Pst). However, the molecular mechanism of Pst effectors involved in HTSP resistance remains unclear. In this study, we determined the interaction between two Pst effectors, PstCEP1 and PSTG_11208, through yeast two‐hybrid (Y2H), bimolecular fluorescence complementation (BiFC), and pull‐down assays. Transient overexpression of PSTG_11208 enhanced HTSP resistance in different temperature treatments. The interaction between PstCEP1 and PSTG_11208 inhibited the resistance enhancement by PSTG_11208. Furthermore, the wheat apoplastic thaumatin‐like protein 1 (TaTLP1) appeared to recognize Pst invasion by interacting with PSTG_11208 and initiate the downstream defence response by the pathogenesis‐related protein TaPR1. Silencing of TaTLP1 and TaPR1 separately or simultaneously reduced HTSP resistance to Pst in XY6. Moreover, we found that PstCEP1 targeted wheat ferredoxin 1 (TaFd1), a homologous protein of rice OsFd1. Silencing of TaFd1 affected the stability of photosynthesis in wheat plants, resulting in chlorosis on the leaves and reducing HTSP resistance. Our findings revealed the synergistic mechanism of effector proteins in the process of pathogen infection.

项与 C16orf72 相关的新闻（医药）

2023-03-07

·生物谷

Nat Commun：一种特殊基因或能参与癌症发生及机体的细胞压力反应

来自美国西北大学等机构的科学家们通过研究识别出了一种特殊基因，其或许在机体应对分子压力源的细胞反应中扮演着重要角色，比如DNA损伤等。有研究表明，HAPSTR1 (C16orf72)或许是一种能调节机体应对分子压力源的细胞反应的新型通路中的关键组分，这些分子压力源包括DNA损伤、营养匮乏和蛋白质的错误折叠等。近日，一篇发表在国际杂志Nature Communications上题为“The HAPSTR2 retrogene buffers stress signaling and resilience in mammals”的研究报告中，来自美国西北大学等机构的科学家们通过研究识别出了一种特殊基因，其或许在机体应对分子压力源的细胞反应中扮演着重要角色，比如DNA损伤等。研究者Marc Mendillo博士表示，此前我们通过研究识别并分析了HAPSTR1的特征，其能在多种细胞中进行表达。这种名为HAPSTR1的新基因主要会在脑癌、睾丸癌和特定类型的人类癌症中进行表达。所有的人类细胞中都包含能促使其抵御不同类型细胞压力和环境压力的信号通路，然而，由于这些压力反应通路几乎总是会被单独进行研究，而帮助调节并关联不同压力反应通路的机制，研究人员却知之甚少。在此前研究中，研究者Mendillo及其同事发现，HAPSTR1能与一种名为HUWE1的蛋白相互作用并被其降解，HUWE1往往会参与到不同人类癌症和神经发育障碍中，该蛋白是一种E3泛素连接酶，意味着其功能就是去捕捉特定的其它蛋白并对其进行降解。研究者表示，HUWE1和HAPSTR1之间有着一种意想不到的关系，HUWE1能协助HAPSTR1控制压力信号，反过来HUWE1又会促进HAPSTR1的降解。一种特殊基因或能参与癌症发生及机体的细胞压力反应。图片来源：Nature Communications (2023). DOI:10.1038/s41467-022-35697-1 在这项最新研究中，研究人员发现，HAPSTR2是HAPSTR1的一种同源物（或复制品）；在正常的生理状况下，HAPSTR2能与HAPSTR1相互作用，并独立于HUWE1来增强蛋白质的稳定性，当HAPSTR1被抑制时，HAPSTR2就能接管其功能并缓冲细胞中的压力反应。这些研究结果或能帮助改善科学家们理解癌症和其它疾病如何拦截压力反应程序从而得以生存。研究者Mendillo说道，压力反应通路发挥着重要的保护性角色，但癌症会利用这些通路来促进癌细胞得以生存和增殖；此外，HAPSTR家族也存在于所有人类细胞中，这种基因并没有明显的功能丧失突变，这就让我们相信这些基因对生命或许非常重要。后期研究人员将会重点理解HAPSTR蛋白质功能背后的机制并识别出用于开发癌症新型疗法的潜在疗法靶点。最后研究者表示，HAPSTR1蛋白似乎对生命和癌症的发生发展非常重要，对HAPSTR1的发现或许揭示了癌细胞巩固这一途径的额外机制，这对于理解癌症对疗法的耐受性和转移机制都非常重要，而这些都是我们理想中希望在癌症中所关闭的东西。（生物谷Bioon.com）原始出处： David R Amici, Harun Cingoz,Milad J Alasady, et al. The HAPSTR2 retrogene buffers stress signaling and resilience in mammals, Nature Communications (2023). DOI:10.1038/s41467-022-35697-1