预约演示

更新于：2025-05-07

MetP

更新于：2025-05-07

基本信息

别名-

简介-

关联

项与 MetP 相关的药物

SYNB-1353

靶点

MetDC x MetP

作用机制

MetDC刺激剂 [+3]

在研机构-

原研机构

Synlogic, Inc.

在研适应症-

非在研适应症

同型半胱氨酸尿症

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

项与 MetP 相关的临床试验

NCT05462132

/ Completed临床1期

A Phase 1, Dose-escalation, Randomized, Placebo-Controlled Study to Assess the Safety, Tolerability, and Pharmacodynamics of SYNB1353 in Healthy Volunteers

This is a Phase 1, double-blind (Sponsor-open), placebo-controlled, randomized, dose-escalation, inpatient study using a multiple-ascending dose (MAD) design to assess the safety, tolerability, and PD of SYNB1353 in HVs.

开始日期2022-07-07

申办/合作机构

Synlogic, Inc.

100 项与 MetP 相关的临床结果

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100 项与 MetP 相关的转化医学

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0 项与 MetP 相关的专利（医药）

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项与 MetP 相关的文献（医药）

2025-02-01·Journal of Environmental Management

The influence of photoperiod and organic carbon levels in parabens removal from wastewater by Chlorella vulgaris

Article

作者: Maia, Carolina ; Sousa, Henrique ; Simões, Manuel ; Sousa, Cátia A ; Vale, Francisca

Parabens are emerging contaminants due to their abundant use as preservatives and inefficient treatment in wastewater (WW) treatment plants. To overcome the limitations of WW treatment plants in removing parabens, microalgae-based bioremediation has aroused great interest as an effective and sustainable process. Nevertheless, several factors affect the WW bioremediation capacity, which must be studied to achieve an effective biological treatment. The main objective of the present work was to evaluate the effects of photoperiod and WW composition, specifically organic carbon concentration (sourced as glucose), on the ability of the microalga Chlorella vulgaris to remove methylparaben (MetP). For that, two photoperiods (12/12 h light/dark and 24 h light) were studied and the composition of synthetic WW (SWW) was manipulated to have a glucose concentration of 0, 3, 30, or 300 mg/L. It was observed that the photoperiod significantly affects the bioremediation process. For a 12/12 h photoperiod, MetP was not removed. Removal was effective for a 24 h photoperiod, with percentages of MetP removal over 88% for glucose concentrations lower than 30 mg/L, decreasing for higher glucose levels. MetP photodegradation was negligible. For the 24 h photoperiod, it was possible to verify that higher glucose concentrations decreased microalga growth, with a decrease in the specific growth rate and the production of photosynthetic pigments. Furthermore, with the increase of the glucose concentration, the MetP constant rate of degradation decreased and its half-life time increased, taking longer to degrade the contaminant (through diauxic growth). Also, C. vulgaris exhibited strong growth ability and removed over 80% of nitrogen and phosphorous, unaffected by the presence of MetP and proportional to glucose levels, underscoring its potential for treating WW contaminated with high concentrations of parabens.

2008-12-02·Biochemistry3区 · 生物学

Methionine Uptake in Corynebacterium glutamicum by MetQNI and by MetPS, a Novel Methionine and Alanine Importer of the NSS Neurotransmitter Transporter Family

3区 · 生物学

Article

作者: Nettekoven, Jeannine A. ; Krämer, Reinhard ; Forrest, Lucy R. ; Trötschel, Christian ; Burkovski, Andreas ; Follmann, Martin ; Mohrbach, Tobias ; Marin, Kay

The soil bacterium Corynebacterium glutamicum is a model organism in amino acid biotechnology. Here we present the identification of two different L-methionine uptake systems including the first characterization of a bacterial secondary methionine carrier. The primary carrier MetQNI is a high affinity ABC-type transporter specific for l-methionine. Its expression is under the control of the transcription factor McbR, the global regulator of sulfur metabolism in C. glutamicum. Besides MetQNI, a novel secondary methionine uptake system of the NSS (neurotransmitter:sodium symporter) family was identified and named MetP. The MetP system is characterized by a lower affinity for methionine and uses Na(+) ions for energetic coupling. It is also the main alanine transporter in C. glutamicum and is expressed constitutively. These observations are consistent with models of methionine, alanine, and leucine bound to MetP, derived from the X-ray crystal structure of the LeuT transporter from Aquifex aeolicus. Complementation studies show that MetP consists of two components, a large subunit with 12 predicted transmembrane segments and, surprisingly, an additional subunit with one predicted transmembrane segment only. Thus, this new member of the NSS transporter family adds a novel feature to this class of carriers, namely, the functional dependence on an additional small subunit.

2004-03-01·Research in Microbiology2区 · 生物学

The metNPQ operon of Bacillus subtilis encodes an ABC permease transporting methionine sulfoxide, d- and l-methionine

2区 · 生物学

Article

作者: Dassa, Elie ; Hullo, Marie-Francoise ; Martin-Verstraete, Isabelle ; Danchin, Antoine ; Auger, Sandrine

The Bacillus subtilis yusCBA operon, which encodes an ABC-type transporter, contains an S-box motif in its promoter region. We showed that the expression of these genes is repressed via the S-box system when methionine is available. The YusCB proteins are involved in the transport of both d- and l-methionine but also methionine sulfoxide. A yusCB mutant is unable to grow in the presence of 5 microM l-methionine or 100 microM methionine sulfoxide, while it grows similarly to the wild type with 100 microM l-methionine and 1 mM methionine sulfoxide. Other uptake systems are therefore present for these two compounds. In contrast, the Yus ABC transporter corresponds to the sole d-methionine uptake system. We propose to rename yusC, yusB and yusA as metN, metP and metQ, respectively.

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