更新于：2024-09-19

RHOQ

更新于：2024-09-19

基本信息

别名

ARHQ、ras homolog family member Q、Ras-like protein family member 7A

+ [5]

简介

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

关联

100 项与 RHOQ 相关的临床结果

登录后查看更多信息

100 项与 RHOQ 相关的转化医学

登录后查看更多信息

0 项与 RHOQ 相关的专利（医药）

登录后查看更多信息

187

项与 RHOQ 相关的文献（医药）

2024-04-12·ACS Infectious Diseases

Role of Macrophage PIST Protein in Regulating Leishmania major Infection

Article

作者: Gadpayle, Mandip Pratham ; Datta, Rupak ; Samanta, Suman ; Das, Swagata ; Dutta, Priyanka ; Maiti, Sankar ; Banerjee, Sourav

PDZ protein interacting specifically with Tc10 or PIST is a mammalian trans-Golgi resident protein that regulates subcellular sorting of plasma membrane receptors. PIST has recently emerged as a key player in regulating viral pathogenesis. Nevertheless, the involvement of PIST in parasitic infections remains unexplored. Leishmania parasites infiltrate their host macrophage cells through phagocytosis, where they subsequently multiply within the parasitophorous vacuole (PV). Host cell autophagy has been found to be important in regulating this parasite infection. Since PIST plays a pivotal role in triggering autophagy through the Beclin 1-PI3KC3 pathway, it becomes interesting to identify the status of PIST during Leishmania infection. We found that while macrophage cells are infected with Leishmania major (L. major), the expression of PIST protein remains unaltered; however, it traffics from the Golgi compartment to PV. Further, we identified that in L. major-infected macrophage cells, PIST associates with the autophagy regulatory protein Beclin 1 within the PVs; however, PIST does not interact with LC3. Reduction in PIST protein through siRNA silencing significantly increased parasite burden, whereas overexpression of PIST in macrophages restricted L. major infectivity. Together, our study reports that the macrophage PIST protein is essential in regulating L. major infectivity.

2024-01-11·[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

[Clinical pathological and genetic mutation characteristics of conjunctival lymphoepithelial carcinoma].

Article

作者: Guo, Y T ; Lin, J Y ; Li, J ; Wang, Y C

目的： 分析结膜淋巴上皮癌的临床病理学和基因突变特征。 方法： 回顾性病例系列研究。收集2006年1月至2022年12月于天津市眼科医院诊断为结膜淋巴上皮癌且接受肿瘤切除手术的3例患者资料和4份石蜡标本（其中1例患者先后行2次手术），采用免疫组织化学染色方法检测上皮抗原和淋巴细胞性抗原，采用原位杂交方法检测Epstein-Barr病毒（EBV）编码的RNA（EBER），应用二代测序方法对2例患者的3份标本进行全外显子组测序。 结果： 3例患者均为男性，年龄均大于65岁，病程3~44个月。均为单眼发病，肿瘤位于球结膜或角结膜缘，呈红色，肿瘤最大径4~20 mm。影像学检查显示肿瘤位于眼球前方，眶骨、眼外肌、视神经和副鼻窦未受累。所有患者均无局部淋巴结转移。病理表现为未分化癌巢伴有显著的反应性淋巴细胞、浆细胞浸润；肿瘤细胞呈广谱细胞角蛋白、上皮膜抗原、肿瘤蛋白40和肿瘤蛋白63阳性，细胞增殖抗原Ki67增殖指数大于80%；淋巴细胞分化簇20阳性、CD3阳性、CD8阳性；原位杂交显示例1患者的2份标本部分瘤细胞表达EBER。二代测序显示3份标本发生体细胞突变的基因个数分别为58、50和36个，突变基因参与的信号通路富集于黑色素瘤信号通路、缺口蛋白1信号通路和大鼠肉瘤同源物家族Q三磷酸鸟苷酶循环；生化过程富集于氨基酸饥饿后反应，程序性坏死，调控脂类合成、钠离子转运和染色体分离等；3份标本均发生突变的基因是癫痫阈值2（SZT2），并且SZT2参与氨基酸饥饿后反应。1例行部分切除手术后40个月行第2次完整切除手术，另外2例行完整切除手术；3例均未行放射治疗或化学治疗，2例未复发，1例失访。 结论： 结膜淋巴上皮癌伴有明显的淋巴细胞、浆细胞浸润，部分病例与EBV感染有关，结膜淋巴上皮癌存在SZT2等基因突变。.

2024-01-01·Developmental Science

Dynamics of cognitive predictors during reading acquisition in a sample of children overrepresented for dyslexia risk

Article

作者: Blockmans, Lauren ; Kievit, Rogier ; Ghesquière, Pol ; Vandermosten, Maaike ; Wouters, Jan

AbstractLiteracy acquisition is a complex process with genetic and environmental factors influencing cognitive and neural processes associated with reading. Previous research identified factors that predict word reading fluency (WRF), including phonological awareness (PA), rapid automatized naming (RAN), and speech‐in‐noise perception (SPIN). Recent theoretical accounts suggest dynamic interactions between these factors and reading, but direct investigations of such dynamics are lacking. Here, we investigated the dynamic effect of phonological processing and speech perception on WRF. More specifically, we evaluated the dynamic influence of PA, RAN, and SPIN measured in kindergarten (the year prior to formal reading instruction), first grade (the first year of formal reading instruction) and second grade on WRF in second and third grade. We also assessed the effect of an indirect proxy of family risk for reading difficulties using a parental questionnaire (Adult Reading History Questionnaire, ARHQ). We applied path modeling in a longitudinal sample of 162 Dutch‐speaking children of whom the majority was selected to have an increased family and/or cognitive risk for dyslexia. We showed that parental ARHQ had a significant effect on WRF, RAN and SPIN, but unexpectedly not on PA. We also found effects of RAN and PA directly on WRF that were limited to first and second grade respectively, in contrast to previous research reporting pre‐reading PA effects and prolonged RAN effects throughout reading acquisition. Our study provides important new insights into early prediction of later word reading abilities and into the optimal time window to target a specific reading‐related subskill during intervention.

项与 RHOQ 相关的新闻（医药）

2023-12-22

·今日头条

重大突破！复旦大学徐彦辉团队Science发文

本文为转化医学网原创，转载请注明出处作者：Sophia 导读：转录起始是一个复杂的过程，其机制尚不完全清楚。 12月22日，复旦大学徐彦辉团队在国际知名期刊《Science》在线发表了题为”Structural visualization of transcription initiation in action“的研究论文，该研究分别测定了新生RNA长度达到2到17个核苷酸时，在较少G启动子上停止RNA聚合酶II的新生转录复合物TC2到TC17的结构。将这些结构连接起来，生成了一个电影和一个工作模型。 https://www.science.org/doi/10.1126/science.adi5120 研究背景 01 为了实现复杂的转录调控，真核生物 RNA 聚合酶 II （Pol II）本身不会打开核心启动子，需要一般转录因子（GTF）（总共 ~38 个多肽）来组装预起始复合物（PIC）。然后，PIC 依次转化为开放启动子 PIC 复合物（OC）、初始转录复合物（ITC）和早期延伸复合物（EEC）。先前的研究报告说，在这些过程中发生了显著的功能和成分变化。然而，潜在的分子机制在很大程度上仍然难以捉摸。该研究分别测定了新生RNA长度达到2到17个核苷酸时，在较少G启动子上停止RNA聚合酶II的新生转录复合物TC2到TC17的结构。将这些结构连接起来，生成了一个电影和一个工作模型。当最初合成的RNA生长时，一般转录因子(GTFs)仍然与启动子结合，转录泡扩大。三磷酸核苷(NTP)驱动的RNA-DNA易位和模板链在一个近乎封闭的通道中积累可能促进从初始转录复合物(ITCs) (TC2到TC9)到早期延伸复合物(EECs) (TC10到TC17)的转变。研究结果 02 本研究，结构分析揭示了明显的复杂重组。从 PIC 开始，GTF TFIIH 偶联三磷酸腺苷（ATP）水解的能量，将下游启动子转位至 Pol II，从而产生包含 ~13 nt 转录气泡的 OC，转录起始位点（TSS）位于活性位点。然后，OC 转化为 ITC（TC2 至 TC9），在此期间，上游启动子和 GTF 保持与 Pol II 的结合，因此转录泡在活性中心内从 14 nt 扩大到 21 nt。熔化的模板链引导新生 RNA 的合成，当 Pol II 从 2 nt 增长到 9 nt 时，它会增加其与 Pol II 的结合，这与从流产转录到逃逸承诺的过渡相关。TC9 和 TC10 之间的差异揭示了尖锐的 ITC-EEC 转变，并表明核苷三磷酸（NTP）驱动的 RNA-DNA 易位和模板链在几乎封闭的通道中的积累可能会使通道膨胀，导致 GTF 解离、气泡破裂和启动子逃逸。TC10 至 TC17 的结构揭示了 EEC 构象，表明 Pol II 逃离起始区域并在启动子上继续，然后是暂停、RNA 加帽、暂停释放和生产性延伸。研究结果 03 GTFs通过多次相互作用帮助Pol II打开核心启动子，这也为Pol II从启动子中逃逸创造了障碍，因此最终必须被破坏。我们的研究提供了转录起始作用的结构可视化，以了解转录机制为何以及如何发生如此显著的变化。核酸的冷冻电镜图显示在周边。代表性复合物和核酸的示意图分别显示在中心区域的外环和内环中。指出了Pol II的功能状态和转录气泡。DNA易位的方向用箭头表示。参考资料： https://www.science.org/doi/10.1126/science.adi5120 注：本文旨在介绍医学研究进展，不能作为治疗方案参考。如需获得健康指导，请至正规医院就诊。热门·直播/活动 🕓 北京｜12月19日-20日 ▶第四届单细胞测序技术应用研讨会暨单细胞&空间组学研讨会（日程稍后公布）点击对应文字查看详情

临床终止临床研究寡核苷酸