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更新于：2025-05-07

MAN1A1

更新于：2025-05-07

基本信息

别名

Alpha-1,2-mannosidase IA、Man(9)-alpha-mannosidase、MAN1A1

+ [4]

简介

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

关联

项与 MAN1A1 相关的药物

VCAR300

靶点

MAN1A1 x Phosphatidylserine

作用机制

MAN1A1 inhibitors [+1]

在研机构

VITRUVIAE INC.

原研机构

VITRUVIAE INC.

在研适应症

乳腺癌 [+3]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 MAN1A1 相关的临床结果

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100 项与 MAN1A1 相关的转化医学

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0 项与 MAN1A1 相关的专利（医药）

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141

项与 MAN1A1 相关的文献（医药）

2025-03-01·Applied Biochemistry and Biotechnology

Different Effects of Deglycosylation on the Lactose Sensing Ability of Mesophilic and Thermophilic Cellobiose Dehydrogenases

Article

作者: Wang, Xingbao ; Zhu, Sirong ; Xue, Yunlong ; Huang, Xiaozhen ; Zhang, Zhenyu ; Gong, Weili ; Shao, Yue ; Ma, Yaohong

The development of an efficient lactose biosensor employing cellobiose dehydrogenases (CDHs) for monitoring and precise control of the lactose levels in dairy-based products is extremely important for the health of lactose-intolerant population. In this study, the mesophilic (Nc_CDH) and thermophilic (Ct_CDH-A, Ct_CDH-B) CDHs were successfully obtained by heterologous expression and treated with α-1,2-mannosidase and endoglycosidase H to prepare the deglycosylated forms (Nc_dCDH, Ct_dCDH-A, and Ct_dCDH-B); then, the effects of deglycosylation on the catalytic activity in solution and electrochemical performance on electrodes for lactose detection were systematically investigated. In solution, Nc_dCDH was more stable and had a higher V_max value and lower K_M value than Nc_CDH at different temperatures and pH values. In contrast, deglycosylation had adverse effects on the stability of Ct_CDH-A and Ct_CDH-B. When the CDHs mixed with multi-walled carbon nanotubes were dropped and immobilized on electrodes, with regard to Nc_CDH, in the presence of the same concentration of lactose, the detection current of the electrode modified with Nc_dCDH was higher than that of the electrode modified with Nc_CDH, and it had a lower detection limit (2.006 mM) and higher sensitivity (39.37 μA.mmol.L^-1.cm^-2). However, with respect to the thermophilic CDHs, the sensitivity was lowered and the detection limit was increased after deglycosylation. The discrepancy may result from two reasons: N-glycosylation may play a more crucial role in thermostability and structural stability of thermophilic CDHs, and the distribution sites of glycosylated residues may affect the electron transfer kinetics. This study is a step toward using CDH as an electron transfer-based lactose biosensor.

2025-02-01·Physiology & Behavior

Plasma proteomic signature of chronic psychosocial stress in mice

Article

作者: O'Connor, Lewis A ; English, Jane A. ; O'Leary, Olivia F ; Scaife, Caitriona ; Golubeva, Anna V ; Golubeva, Anna V. ; Nolan, Yvonne M ; Donoso, Francisco ; O'Connor, Lewis A. ; Nolan, Yvonne M. ; Melo, Thieza G. ; Melo, Thieza G ; English, Jane A ; O'Leary, Olivia F.

Chronic stress significantly impacts both physical and mental wellbeing, increasing risk of cardiovascular disease, immune dysregulation, and psychiatric conditions such as depression and anxiety disorders. The plasma proteome is a valuable source of biomarkers of health and disease, but the limited number of studies exploring the potential of the plasma proteome as a biomarker for stress-related disorders underscores the importance of further investigation of the effects of chronic stress on the plasma proteome. The aim of this study was to examine the effect of a 5-week chronic psychosocial stress paradigm on the plasma proteome in mice and to determine if any affected proteins correlated with stress-induced changes in behaviour and physiology, and thus might represent biomarkers of negative impacts of chronic stress. Using LC-MS/MS proteomic analysis, 38 proteins in the mouse plasma proteome were identified to be affected by chronic psychosocial stress. Functional analysis revealed that these proteins clustered into biological functions including inflammatory response, regulation of the immune response, complement and coagulation cascades, lipid metabolic process, and high-density lipoprotein particles. Correlation analyses of the identified proteins with stress-induced behavioral or physiological changes stress revealed significant correlations between stress-induced anxiety-like behaviour and Phosphatidylinositol-glycan-specific phospholipase D, Complement C2, Epidermal growth factor receptor, Prosaposin, Actin-related protein 2/3 complex subunit 1B, Maltase-glucoamylase, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA and Fibrinogen-like protein 1. Chronic psychosocial stress blunted acute stress-induced corticosterone release, and this correlated with abundance of Pyrethroid hydrolase Ces2a; N-fatty-acyl-amino acid synthase/hydrolase Pm20d1, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, Alpha-2-macroglobulin-P and L-selectin. Finally, stress-induced reductions in both brown and epididymal fat correlated with Phosphatidylinositol-glycan-specific phospholipase D, Complement C2, Epidermal growth factor receptor, Kininogen-1, Apolipoprotein M, Angiopoietin-related protein 3, Proprotein convertase subtilisin/kexin type 9, and Lipopolysaccharide-binding protein. These findings demonstrate that chronic psychosocial stress induces alterations in plasma proteins implicated in key biological processes and pathways related to stress response, immune function, and lipid metabolic regulation. Further investigation into these proteins may provide new avenues for identification of biomarkers or mediators of stress-induced pathology.

2025-01-01·Iranian journal of child neurology

Rafiq Syndrome: Old Variant in MAN1B1 Gene and Some New Phenotypic Features.

Article

作者: Saka Güvenç, Merve ; Özgün, Nezir

Rafiq syndrome is a congenital disorder of glycosylation type II that develops due to mutations in the Mannosidase Alpha Class 1B Member 1 (MAN1B1) gene encoding α 1,2-mannosidase. In the literature, 45 patients have been reported to date. This study presents a patient with some phenotypic traits that differ from previously reported patients with Rafiq syndrome.Since the patient was not diagnosed despite detailed examinations, whole exome sequencing was performed. The patientss' homozygous c.1000 C>T (p.Arg334Cys) pathogenic variant was detected in the MAN1B1 gene (NM_016219.5), which was consistent with Rafiq syndrome. Our patient's clinical findings were mainly similar to those of previously reported patients. However, our patient had feeding difficulty that started to improve after the fifth month and persistent hyperekplexia . Feeding difficulty and hyperekplexia concomitant to MAN1B1 gene mutation are reported for the first time. More extensive case series are needed to understand whether these findings are part of the syndrome or incidental comorbid conditions.

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