更新于：2024-09-05
SOCS6
更新于：2024-09-05
基本信息
别名 CIS-4、CIS4、Cish4 + [11] |
简介 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. |
关联
100 项与 SOCS6 相关的临床结果
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100 项与 SOCS6 相关的转化医学
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2024-02-18International immunopharmacology
L-arginine attenuates Streptococcus uberis-induced inflammation by decreasing miR155 level.
Article
作者: Yabing Gao ; Jinye Lu ; Zhenglei Wang ; Naiyan Sun ; Binfeng Wu ; Xinru Han ; Yuzhen Liu ; Rui Yu ; Yuanyuan Xu ; Xiangan Han ; Jinfeng Miao
L-arginine, as an essential substance of the immune system, plays a vital role in innate immunity. MiR155, a multi-functional microRNA, has gained importance as a regulator of homeostasis in immune cells. However, the immunoregulatory mechanism between L-arginine and miR155 in bacterial infections is unknown. Here, we investigated the potential role of miR155 in inflammation and the molecular regulatory mechanisms of L-arginine in Streptococcus uberis (S. uberis) infections. And we observed that miR155 was up-regulated after infection, accompanying the depletion of L-arginine, leading to metabolic disorders of amino acids and severe tissue damage. Mechanically, the upregulated miR155 mediated by the p65 protein played a pro-inflammatory role by suppressing the suppressor of cytokine signaling 6 (SOCS6)-mediated p65 ubiquitination and degradation. This culminated in a violently inflammatory response and tissue damage. Interestingly, a significant anti-inflammatory effect was revealed in L-arginine supplementation by reducing miR155 production via inhibiting p65. This work firstly uncovers the pro-inflammatory role of miR155 and an anti-inflammatory mechanism of L-arginine in S.uberis infection with a mouse mastitis model. Collectively, we provide new insights and strategies for the prevention and control of this important pathogen, which is of great significance for ensuring human food health and safety.
2023-12-21Biological psychiatry
A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis.
Article
作者: Lu Zeng ; Masashi Fujita ; Zongmei Gao ; Charles C White ; Gilad S Green ; Naomi Habib ; Vilas Menon ; David A Bennett ; Patricia Boyle ; Hans-Ulrich Klein ; Philip L De Jager
BACKGROUND:
Depression, a common psychiatric illness and global public health problem, remains poorly understood across different life stages, which hampers the development of novel treatments.
METHODS:
To identify new candidate genes for therapeutic development, we performed differential gene expression analysis of single-nucleus RNA sequencing data from the dorsolateral prefrontal cortex (N=424) of older adults in relation to ante-mortem depressive symptoms. Additionally, we integrated genome-wide association study (GWAS) results for depression (N=500,199) along with genetic tools for inferring the expression of 14,048 unique genes in seven cell types and 52 cell subtypes to perform a transcriptome-wide association study (TWAS) of depression followed by Mendelian randomization.
RESULTS:
Our single-nucleus TWAS analysis identified 68 candidate genes for depression, which showed the greatest number being in excitatory and inhibitory neurons. 53 of 68 genes were novel compared to previous studies. Notably, gene expression in different neuronal subtypes have varying effects on depression risk. Higher genetically correlated traits with depression, such as neuroticism, shared more TWAS genes than less correlated traits. Complementing these analyses, differential gene expression analysis across 52 neocortical cell subtypes showed that genes such as KCNN2, SCAI, WASF3 and SOCS6 are associated with late-life depressive symptoms in specific cell subtypes.
CONCLUSIONS:
These two sets of analyses illustrate the utility of large snucRNAseq data to uncover both genes whose expression is altered in specific cell subtypes in the context of depressive symptoms and to enhance the interpretation of well-powered GWAS so that we can prioritize specific susceptibility genes for further analysis and therapeutic development.
2023-12-20Pharmaceuticals (Basel, Switzerland)
Identification of a New Integration Site and Study on Site-Specific Integration in CHO-K1 Cells.
Article
作者: Hong Liu ; Wei Zhang ; Liping Xie ; Youjia Hu
Site-specific integration is an important approach used to address the problem of unstable cell lines in industry. In this study, we observed a reduction in the gene copy number and antibody production in a CHOK1 cell line BA03 capable of high antibody expression. We identified a new integration site named locus 7 in the intron region of the parva gene through sequencing, FISH, and genome walking. We demonstrate that the integration of the exogenous gene at this locus does not affect the transcription of the parva and, therefore, has a minimal impact on cell growth. We designed sgRNA and donor vectors to integrate the etanercept-coding gene into locus 7 and obtained a cell line, SSI-4. We performed a passaged stability study on SSI-4 and proved the possibility of the stable, site-specific integration of exogenous genes at this locus in terms of integration site, copy number, expression level, and cell growth. In summary, our study has identified a new integration site suitable for site-specific integration, which lays the foundation for the subsequent development of site-specific integration cell lines.
2023-08-07
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