更新于：2024-11-01

TMCC

更新于：2024-11-01

基本信息

别名-

简介-

关联

项与 TMCC 相关的药物

WO2024144806

专利挖掘

靶点

TMCC

作用机制-

在研机构

财团法人生物技术开发中心

原研机构

DCB USA LLC [+1]

在研适应症

肿瘤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 TMCC 相关的临床结果

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100 项与 TMCC 相关的转化医学

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0 项与 TMCC 相关的专利（医药）

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项与 TMCC 相关的文献（医药）

2024-12-01·Molecular and Cellular Endocrinology

Transmembrane and coiled-coil domain family 3 gene is a novel target of hepatic peroxisome proliferator-activated receptor γ in fatty liver disease

Article

作者: Matsusue, Kimihiko ; Sakaguchi, Ai ; Aibara, Daisuke

The peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor abundantly expressed in the nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the mechanism by which PPARγ regulates the transmembrane and coiled-coil domain family 3 (Tmcc3) gene in the liver. We found that TMCC3 is highly expressed in the fatty liver of humans and mice with NAFLD and alcoholic fatty liver disease. Three exon 1 variants (Tmcc3-1a, -1b, and -1c) of mouse Tmcc3 were identified. TMCC3-1B was highly expressed in the fatty liver of type 2 diabetic ob/ob mice; however, this increase in expression was ameliorated by liver-specific knockout of PPARγ. Reporter assays and electrophoretic mobility shift assays showed that PPARγ positively regulates Tmcc3-1b and -1c transcription through the same PPARγ-responsive element present in the 5'-region of each Tmcc3. Altogether, our results indicate that Tmcc3 is a novel PPARγ target in the fatty liver disease.

2024-09-25·Journal of Physics: Condensed Matter

Enhancement of superconductivity in Zr₂S₂C arising from phonon softening on transition from bulk to monolayer

Article

作者: Ahuja, Rajeev ; Kumar, Rakesh ; Jamwal, Prarena

AbstractWe report a new compound, Zr2S2C, belonging to the transition metal carbo-chalcogenide (TMCC) family. Through first-principles calculations, our analysis of phonon dispersion spectra indicates that the compound is dynamically stable in both bulk and monolayer forms. We systematically investigated the electronic structure, phonon dispersion, and electron–phonon coupling (EPC) driven superconducting properties in bulk and monolayer Zr2S2C. The results demonstrate the metallic character of bulk Zr2S2C, with a weak EPC strength (λ) of 0.41 and superconducting critical temperature (

) of ∼3 K. The monolayer Zr2S2C has an enhanced λ of 0.62 and

of ∼6.4 K. The increased λ value in the monolayer results from the softening of the acoustic phonon mode. We found that when biaxial strain is applied, the low energy acoustic phonon mode in monolayer becomes even softer. This softening leads to a transformation of the Zr2S2C monolayer from its initial weak coupling state (λ = 0.62) to a strongly coupled state, resulting in an increased λ value of 1.33. Consequently, the superconducting critical temperature experiences a twofold increase. These findings provide a theoretical framework for further exploration of the layered two-dimensional TMCC family, in addition to offering valuable insights.

2023-12-01·Heart, Lung and Circulation

Circulating Biomarkers and Risk of Hypertension: A Two-Sample Mendelian Randomisation Study

Article

作者: Li, Jin ; Yao, Yue-Xian ; Yao, Pei-Sen

OBJECTIVEThis study systematically assessed circulating proteins to identify new serum biomarkers and risk of hypertension using Mendelian randomisation.METHODSThe associations between 4,782 human circulating proteins and the risk of hypertension were evaluated using two-sample Mendelian randomisation. The FinnGen study demonstrated a link between genetic predisposition and hypertension in 85,438 cases and 223,663 controls.RESULTSInverse variance weighted and sensitivity analysis revealed nine proteins in circulation that have a causative effect on hypertension. SMOC1 and TIE1 were determined to be causative factors in the decreased likelihood of developing hypertension, with odds ratios of 0.86 (95% CI 0.81-0.91; p=1.06e-06) and 0.96 (95% CI 0.94-0.98; p=9.39e-05), respectively. NDUFB4, ETHE1, POFUT2, TRIL, ADAM23, GXYLT1, OXT, TPST2, and TMCC3 showed a possible connection to hypertension.CONCLUSIONSThis two-sample Mendelian randomisation study found that SMOC1 and TIE1 are causally linked to hypertension, making them a promising target for therapy.