更新于：2024-11-01

Infarction, Posterior Cerebral Artery

大脑后动脉梗塞

更新于：2024-11-01

基本信息

别名

Embolic Infarction, Posterior Cerebral Artery、Infarct, PCA、Infarction, PCA

+ [26]

简介

NECROSIS induced by ISCHEMIA in the POSTERIOR CEREBRAL ARTERY distribution system which supplies portions of the BRAIN STEM; the THALAMUS; TEMPORAL LOBE, and OCCIPITAL LOBE. Depending on the size and location of infarction, clinical features include OLFACTION DISORDERS and visual problems (AGNOSIA; ALEXIA; HEMIANOPSIA).

关联

项与大脑后动脉梗塞相关的药物

[18F]F-PSMA-N5

靶点

PSMA

作用机制

PSMA调节剂 [+1]

在研机构

安徽省立医院（中国科学技术大学附属第一医院）

原研机构

安徽省立医院（中国科学技术大学附属第一医院）

在研适应症

大脑后动脉梗塞 [+1]

非在研适应症-

最高研发阶段早期临床1期

首次获批国家/地区-

首次获批日期1800-01-20

Cenplacel-L (Celularity)

靶点-

作用机制

细胞替代物

在研机构-

原研机构

Celgene Cellular Therapeutics

在研适应症-

非在研适应症

克罗恩病 [+5]

最高研发阶段终止

首次获批国家/地区-

首次获批日期1800-01-20

项与大脑后动脉梗塞相关的临床试验

NCT06536725 / RecruitingN/AIIT

Observation of Clinical Consistency of Organoid-on-chips Drug Sensitivity Detection in Chemotherapy for Prostate Cancer Patients With Visceral Metastasis

This project plans to establish an organoid chip model of prostate cancer patients with internal organ metastasis from surgical or biopsy tissue sources, and test the sensitivity of commonly used chemotherapy drugs based on organoid chip drug sensitivity testing technology to screen out sensitive individualized treatment plans.

开始日期2024-06-01

申办/合作机构

天津医科大学第二医院

NCT06462508 / Recruiting早期临床1期IIT

Head-to-head Comparison of [18F]F-PSMA-N5 With [68Ga]Ga-PSMA-11 PET/CT in Prostate Cancer Diagnosis, Recurrence, and Metastasis: a Prospective Study

To prospectively evaluate the radiodrug biodistribution of a novel PET imaging agent [18F]F-PSMA-N5 in different organs of prostate cancer patients and its diagnostic efficacy in the diagnosis, recurrence and metastasis of prostate cancer, and to compare with [68Ga]Ga-PSMA-11.

开始日期2024-04-20

申办/合作机构

安徽省立医院（中国科学技术大学附属第一医院）

NCT06462495 / Recruiting早期临床1期IIT

Head-to-head Comparison of [18F]F-PSMA-N5 With [18F]F-PSMA-1007 PET/CT in Prostate Cancer Diagnosis, Recurrence, and Metastasis: a Prospective Study

开始日期2024-04-10

申办/合作机构

安徽省立医院（中国科学技术大学附属第一医院）

100 项与大脑后动脉梗塞相关的临床结果

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100 项与大脑后动脉梗塞相关的转化医学

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0 项与大脑后动脉梗塞相关的专利（医药）

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970

项与大脑后动脉梗塞相关的文献（医药）

2024-10-01·Journal of Vascular Surgery Cases, Innovations and Techniques

A technique for prevention of posterior stroke during urgent revascularization of an acutely ischemic left upper extremity

Article

作者: Sexton, Jonathan Jay ; Propper, Brandon ; Koelling, Erin ; Heyda, Lauren M. ; Hata, Kai

Upper extremity acute limb ischemia (ALI) owing to obstruction proximal to the vertebral artery poses the risk of posterior stroke during intervention. We describe a case of upper extremity ALI secondary to thrombosis of the proximal left subclavian artery with thromboembolic occlusion at the brachial bifurcation. The patient underwent a hybrid procedure of open thromboembolectomy with endovascular vertebral artery embolic protection. The patient's distal pulses and upper extremity function returned to baseline, without evidence of posterior stroke. A literature review revealed limited reports of the use of cerebral embolic protection in the setting of emergent thromboembolectomy for upper extremity ALI.

2024-10-01·Experimental Neurology

Hippocampal infarction and generalized seizures predict early mortality after endovascular middle cerebral artery occlusion in mice

Article

作者: Jin, Xuyan ; Ayata, Cenk ; Sasaki, Yuichi ; Chung, David Y ; Imai, Takahiko ; Morais, Andreia

Endovascular middle cerebral artery occlusion (MCAO) is a widely used experimental ischemic stroke model. However, the model carries high early mortality. Our aim was to investigate the factors that influence early mortality within 48 h of reperfusion after transient MCAO. Using C57BL/6 mice, we induced 1-hour endovascular filament MCAO. To introduce heterogeneity of infarct volumes, a subset of animals had additional tandem common carotid artery occlusion (MCAO+CCAO). Continuous video monitoring was used to gain insight into the cause of death. Mortality within 48 h was 25% in the pooled cohort. All animals with early mortality suffered from infarcts in the hippocampus, sometimes accompanied by infarcts in the thalamus and midbrain, which occurred exclusively in the MCAO+CCAO group. All animals with early mortality developed convulsive seizures captured on video monitoring. None of the animals that did not develop convulsive seizures died. Among the three regions, hippocampal infarction appeared necessary for convulsive seizures and early mortality. Our data highlight seizures as the primary cause of mortality within the first 48 h after endovascular filament MCAO, linked to hippocampal infarction. Since hippocampal blood supply is mainly from the posterior cerebral artery (PCA), avoiding concurrent PCA ischemia can decrease mortality in proximal MCAO models.

2024-09-01·Journal of Neurology

Stroke heart injury: the effect of cerebral reperfusion treatment. A 3-year retrospective study

Article

作者: Naccarato, Marcello ; Prandin, Gabriele ; Palacino, Federica ; Scali, Ilario ; Manganotti, Paolo ; Mancinelli, Laura ; Furlanis, Giovanni ; Caruso, Paola ; Vincis, Emanuele

BACKGROUNDCardiac involvement following an acute stroke (Stroke Heart Syndrome-SHS) is an established complication and it is linked to the involvement of sympathetic activation, inflammation, and neuro-endocrine response. Troponin "rise and fall pattern" > 30% is one marker of SHS. The aim of this study was to evaluate the role of reperfusion treatments in the prevention/pathogenesis of SHS with different stroke sizes and locations (OCSP classification).METHODSWe retrospectively analyzed data of 890 patients admitted to the Stroke Unit of Trieste (Italy) between 2018 and 2020. Out of them, 411 met the inclusion criteria (acute ischemic non-lacunar stroke). Clinical data were collected for each patient, imaging characteristics, and markers of cardiac injury [troponin I (TnI), NT-proBNP, "rise and fall pattern" > 30%]. We compared different stroke subtypes according to OCSP, while evaluating any differences in patients with and without SHS.RESULTSIn treated total anterior circulation infarct (TACI) patients, the rate of SHS is lower than in non-treated TACI. Similar SHS rate was found in partial anterior (PACI) and posterior stroke (POCI), and between treated and non-treated patients. Focusing on TACI group, we compared SHS-TACI and non-SHS-TACI, we performed a univariate and multivariate analysis; treatment (OR 0.408 CI95% 0.185-0.900; p = 0.026) and diabetes (OR 2.618 CI95% 1.181-5.803; p = 0.018) were significantly associated to SHS. No clear insular effect was found in SHS development.CONCLUSIONSIn severe anterior stroke (TACI), reperfusion treatment may be effective in preventing SHS. Conversely, diabetes is an independent risk factor for SHS. PACI and POCI have similar troponin elevation rate.

项与大脑后动脉梗塞相关的新闻（医药）

2024-05-02

·生物探索

Mol Cancer | 浙江大学郑祥毅/刘犇/罗金旦揭示R环驱动晚期前列腺癌的生长迟缓和多西他赛化疗敏感性增强

引言R环是一种常见的三链核酸结构，包括DNA-RNA杂交和移位的单链DNA，在转录过程中经常形成，可能归因于基因组稳定性和基因表达调控。最近发现，RNA修饰有助于维持R-环的稳定性，如N6 -甲基腺苷(m6 A)。然而，m6 A修饰的R-环在调节基因转录中的作用仍然知之甚少。2024年4月24日，浙江大学郑祥毅、刘犇及罗金旦共同通讯在Molecular Cancer（IF 37）在线发表题为“Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer”的研究论文，该研究表明共转录R环介导的表观遗传调控驱动晚期前列腺癌的生长迟缓和多西他赛化疗敏感性增强。该研究证明了胰岛素样生长因子2 mRNA结合蛋白(IGF2BPs)以m6A依赖的方式识别R-环。因此，IGF2BPs过表达通过阻止DNA甲基转移酶1(DNMT1)与信号蛋白3F (SEMA3F)启动子的结合，导致前列腺癌(PCa)中R-环水平升高、细胞迁移抑制和细胞生长迟缓。此外，IGF2BPs的K同源性(KH)结构域是其识别m6A的R环所必需的，也是肿瘤抑制功能所必需的。SEMA3F过表达通过调控Hippo通路显著增强前列腺癌多西他赛化疗敏感性。该研究结果表明，IGF2BPs介导了一种独特的R环分解途径，强调了IGF2BPs在转录遗传调控和癌症生物学中作为表观遗传R环读取器的功能重要性。此外，该研究结果首次强调了IGF2BPs作为表观遗传R环读取器在转录遗传调控和癌症生物学中的功能重要性。此外，该研究提供了一个新的RBM15/IGF2BP/DNMT1反组学调控m6A轴，表明在前列腺癌中RNA m6A甲基化和DNA甲基化之间存在新的串扰。在过去的十年中，R环通常被认为是转录的有害后果，导致基因组不稳定。大体上，R环分为生理性和病理性两类。生理性R环通常是由于涉及特定元素的预编程过程而出现的，而病理性R环则是错误地突然发生的。R环最近在生物医学研究中被强调为在基因控制和同源重组修复等细胞过程中发挥重要作用。根据积累的证据，在基因启动子和终止区存在大量的生理R环，似乎生理R环的存在可能有助于基因表达调控。在哺乳动物细胞中，R环通过阻止DNA甲基转移酶(DNMTs)的结合和吸引TET DNA去甲基化酶，与出现在许多基因启动子上的CpG岛的未甲基化状态相关联。一组被称为IGF2BPs的蛋白质参与调节RNA加工。最近的研究表明，IGF2BPs含有RNA识别基序(RRMs)和KH结构域。此外，KH结构域用于识别m6 A修饰，对其生物学功能至关重要。虽然质谱分析结果显示IGF2BP1/3可被S9.6 IP富集，但IGF2BPs在R-loop代谢中的共转录作用尚不清楚。几乎所有的研究都集中在IGF2BPs在细胞质中的功能，如RNA稳定和翻译。模式图（Credit: Molecular Cancer）该研究证明IGF2BPs可以以m6A依赖的方式调节R-环代谢。在细胞核中，IGF2BP蛋白更倾向于结合甲基化DNA：RNA杂交体而不是ssRNA。此外，KH结构域对于IGF2BPs和R-环的结合至关重要。此外，RBM15还负责R环的m6A修饰。更重要的是，该研究提供了一种新的RBM15/IGF2BPs /DNMT1反组学调控m6A轴，表明在前列腺癌中RNA m6A甲基化和DNA甲基化之间存在新的串扰。同时，作为IGF2BPs的共同靶点，SEMA3F与PCa患者的生存相关，提示它可能是一个有前景的生物标志物，可以预测未来前列腺癌的风险。原文链接https://doi.org/10.1186/s12943-024-01994-0责编|探索君排版|探索君文章来源|“iNature”End往期精选围观一文读透细胞死亡(Cell Death) | 24年Cell重磅综述（长文收藏版）热文Nature | 破除传统：为何我们需要重新思考肿瘤的命名方式热文Nature | 2024年值得关注的七项技术热文Nature | 自身免疫性疾病能被治愈吗？科学家们终于看到了希望热文CRISPR技术进化史 | 24年Cell综述

临床1期临床终止