预约演示

更新于：2025-05-07

Magnesium Deficiency

镁缺乏

更新于：2025-05-07

基本信息

别名

Deficiencies, Magnesium、Deficiency, Magnesium、Magnesium Deficiencies

+ [16]

简介

A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)

关联

生育酚乙酸酯/氧化镁/盐酸吡哆醇/苯磷硫胺/核黄素/γ-谷维素/氰钴胺

靶点

Free radicals x MUT

作用机制

自由基抑制剂 [+2]

在研机构

ChoA Pharmaceutical Co., Ltd.

原研机构

ChoA Pharmaceutical Co., Ltd.

在研适应症

镁缺乏

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

韩国

首次获批日期2025-01-17

Magnesium Gluconate

葡萄糖酸镁

靶点-

作用机制-

在研机构-

原研机构-

在研适应症

镁缺乏

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期1800-01-20

项与镁缺乏相关的临床试验

NCT05774015

/ RecruitingN/AIIT

The Effect of Oral Magnesium Supplementation on The Control and Outcomes of Type II Diabetes Mellitus Guided by Serum Ionized Magnesium Level: A Double-Blind Randomized Control Trial

Studies have shown that type 2 diabetic patients (T2DM) may have low serum magnesium levels leading to poor control and outcome of the disease. Supplementation with Mg might improve overall diabetic control and disease outcome. However, there is yet no consensus on whether the ionized (iMg) or the total Mg (tMg) level should be used as a basis to determine the status of Mg in the blood. Recently it was shown that iMg may correlate better with diabetes control than tMg. Therefore, Mg supplements to diabetic patients may improve their disease status. Unfortunately, and to the best of our knowledge all of the available trials on Mg supplementation guided by iMg levels were conducted on healthy volunteers rather than T2DM patients, and they were all for a short period of time (10 days to 10 weeks). Here we hypothesize that supplementations of T2DM patients with Mg based on serum iMg levels correlate better with diabetes control and prognosis. Such hypothesis is supported by a retrospective study that concluded that iMg correlate better with BP control than tMg. In addition, another trial that investigated the effects of three Mg dietary supplements; Mg oxide, Mg citrate and Mg carbonate on healthy female young adults, showed that only Mg oxide led to an increase in the levels of iMg and tMg concentrations when compared to baseline. Furthermore, a case-control study on older diabetic patients revealed a significant association between iMg and HbA1c. This study aims to investigate the effect of supplementing Mg oxide tablets versus placebo tablets guided by serum iMg levels in T2DM patients with or without hypomagnesemia on diabetic control and prognosis.

开始日期2023-09-25

申办/合作机构

University of Sultan Qaboos

[+2]

NCT05903677

/ Not yet recruitingN/AIIT

The Relationship Between Preoperative Levels of Ionized Magnesium and Risk of Acute Kidney Injury After Cardiac Surgery

Detection the relationship between preoperative ionized magnesium levels and the risk of acute kidney injury after cardiac surgery.

开始日期2023-07-01

申办/合作机构

Assiut University

NCT05149820

/ Unknown status临床4期IIT

A Single-Centre Feasibility Study of PROSPECTOR - Point of Care RandOmisation Systems for Performing Embedded Comparative Effectiveness Trials Of Routine Treatments in Critical Care

Every day, doctors and nurses make hundreds of decisions about treatments - like when to start or stop them, or how frequently to give them. Ideally, decisions are based on gold standard evidence from Randomised Controlled Trials (RCTs). Unfortunately, for many treatments little or no evidence exists and clinicians must use knowledge and experience to decide what is best.
As clinicians are all different, this leads to random variation in how treatments are given to patients. For example, magnesium is routinely given in intensive care to prevent abnormal heart rhythms. There is little evidence supporting this, and clinicians vary in how they administer magnesium. Traditional RCTs might be used to examine whether more magnesium is better than less magnesium, but this method is inefficient and expensive for investigating multiple comparative treatment questions.
Clinical trials are becoming more efficient by using existing hospital computer systems to run them. However, research teams continue to perform tasks like randomisation manually. For questions like magnesium supplementation, which occur daily, this is labour intensive and infeasible.
Hospital computer systems also possess mechanisms for prompting and alerting clinicians for particular decisions, reminding them of best practices, warning them of potential problems. These systems may be modified to allow clinicians to randomise patients, under specific conditions.
The investigators propose to assess whether modified computer prompts can be used to highlight the magnesium supplementation decision to clinicians. These would prompt the clinician to evaluate the uncertainty around giving or withholding magnesium in that instance. If in agreement that the optimal decision is unclear, clinicians can choose to randomise the patient within a predetermined trial structure. If the clinician knows better, they may override the prompt and continue with their preference. In both cases, the system learns from the decision and the patient receives optimal care determined by their clinician.

开始日期2022-03-22

申办/合作机构

University College London

[+1]

100 项与镁缺乏相关的临床结果

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100 项与镁缺乏相关的转化医学

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0 项与镁缺乏相关的专利（医药）

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2,249

项与镁缺乏相关的文献（医药）

2025-07-01·Seminars in Cancer Biology

Targeting mineral metabolism in cancer: Insights into signaling pathways and therapeutic strategies

Review

作者: Bhatnagar, Kartik ; Patki, Ninad ; Chaudhary, Sarika ; Motiani, Rajender K ; Raju, Sharon

Cancer remains the second leading cause of death worldwide, emphasizing the critical need for effective treatment and control strategies. Essential minerals such as copper, iron, zinc, selenium, phosphorous, calcium, and magnesium are integral to various biological processes and significantly influence cancer progression through altered metabolic pathways. For example, dysregulated copper levels promote tumor growth, while cancer cells exhibit an increased dependency on iron for signaling and redox reactions. Zinc influences tumor development through pathways such as Akt-p21. Selenium, primarily through its role in selenoproteins, exhibits anticancer potential but may also contribute to tumor progression. Similarly, dietary phosphate exacerbates tumorigenesis, metastasis, and angiogenesis through signaling pathway activation. Calcium, the most abundant mineral in the body, is tightly regulated within cells, and its dysregulation is a hallmark of various cancers. Magnesium deficiency, on the other hand, promotes cancer progression by fostering inflammation and free radical-induced DNA mutations. Interestingly, magnesium also plays a dual role, with low levels enhancing epithelial-mesenchymal transition (EMT), a critical process in cancer metastasis. This complex interplay of essential minerals underscores their potential as therapeutic targets. Dysregulation of these minerals and their pathways could be exploited to selectively target cancer cells, offering novel therapeutic strategies. This review summarizes current research on the abnormal accumulation or depletion of these microelements in tumor biology, drawing evidence from animal models, cell lines, and clinical samples. We also highlight the potential of these minerals as biomarkers for cancer diagnosis and prognosis, as well as therapeutic approaches involving metal chelators, pharmacological agents, and nanotechnology. By highlighting the intricate roles of these minerals in cancer biology, we aim to inspire further research in this critical yet underexplored area of oncology.

2025-05-01·Plant Physiology and Biochemistry

Comprehensive analysis of the effects on photosynthesis and energy balance in tomato leaves under magnesium deficiency

Article

作者: Tian, Hui ; Zhang, Haoran ; Wang, Qiao ; Muhammad, Riaz ; Liang, Bin ; Zhu, Zihan ; Wu, Xiuwen ; Chai, Guohua

Magnesium (Mg), as an essential and central mineral element for chlorophyll biosynthesis, plays a crucial role in plant photosynthesis. Magnesium deficiency inevitably affects the photosynthetic ability of leaves, thereby impairing the yield and quality of crops. However, few studies have revealed the intrinsic mechanisms by which Mg deficiency hinders growth and photosynthesis, particularly by analyzing the processes of light capture, dissipation, absorption, and utilization in tomato. The experiment studied the effects of Mg deficiency on internal structure of leaves, light absorption, electron transfer, photophosphorylation, and carbon assimilation, combined with transcriptome data analyses and key gene screening in tomato leaves. The results showed that Mg deficiency induced obvious leaf chlorosis and damaged stomatal structure, irregular chloroplast structure and degraded thylakoid lamellae, thereby resulting in lower chlorophyll content, net photosynthetic rate, water use efficiency, and biomass. Decreased expression of 11 genes related to light-harvesting antenna proteins suggested that Mg deficiency weakened the light absorption capacity of tomato leaves, Additionally, Mg deficiency inactivated the photochemical reaction centers of photosystem I (PSI) and photosystem II (PSII), and decreased the expression of related genes (PSAA, PSAB, PSBA, and PSBB), leading to a reduction in electron transfer capacity from the donor side of PSII to PSI. Furthermore, Mg deficiency inhibited ATP synthesis and weakened carbohydrate assimilation by reducing carboxylation capacity of the Rubisco enzyme, Rubisco carboxylation rate (Vmax), and triose phosphate transport rate (TPU). The accumulation of carbohydrates in the leaves reduced the efficiency of the Calvin-Benson cycle and ATP/NADPH in Mg-deficient leaves. The down-expressed genes related to cyclic electron transfer (CRR7, NDHB, PNSB, PNSB4, PNSB5) further demonstrated that Mg deficiency may weaken cyclic electron transfer during photosynthesis. Therefore, the reduction in the photosynthetic capacity of Mg-deficient tomato plants was the result of a combination of decreased carbon assimilation capacity, damaged photosynthetic components, changed photosynthetic electron transport and distribution. The findings of this study provide a comprehensive understanding of the underlying mechanisms by which Mg deficiency reduces the photosynthetic performance of tomato leaves and offer a theoretical basis for breeding Mg-tolerant tomato varieties.

2025-05-01·American Journal of Medical Genetics Part A

Adult‐Onset Hypomagnesemia With Secondary Hypocalcemia Caused by a Novel Variant in TRPM6 Gene: A Case Report

Article

作者: Chen, Yan ; Hong, Yunyun ; Liu, Qiang ; Hu, Yuhua ; Liang, Jian

ABSTRACTHereditary hypomagnesemia with secondary hypocalcemia (HSH) is a rare autosomal recessive disorder caused by biallelic variants in the transient receptor potential melastatin 6 (TRPM6) gene, typically presenting in infancy. Currently, there is a lack of reports in the literature on adult‐onset cases. This case report describes a 51‐year‐old male with adult‐onset HSH, presenting with limb weakness, muscle spasms, and electrolyte imbalances, including severe hypomagnesemia (0.28 mmol/L). Genetic testing revealed a novel heterozygous variant in the TRPM6 gene (c.4914del, p.E1638Dfs*8), classified as likely pathogenic. The patient's symptoms significantly improved following magnesium supplementation, and his electrolyte levels gradually normalized. This case highlights the importance of considering HSH in patients with unexplained hypomagnesemia and emphasizes the role of genetic testing in confirming the diagnosis. The findings also suggest that magnesium supplementation can effectively alleviate symptoms and improve the quality of life in patients with adult‐onset HSH. Early recognition and treatment are crucial to prevent potential complications, such as neurological damage.

项与镁缺乏相关的新闻（医药）

2025-03-04

·FierceBiotech

PepGen pauses UK arm of DMD trial that\'s already on hold in US

PepGen disclosed that two patients in the 10-mg/kg cohort had reported asymptomatic magnesium deficiency.\n While PepGen works to persuade the FDA to let it launch a phase 2 trial of its Duchenne muscular dystrophy (DMD) therapy in the U.S., the biotech has decided to pause the U.K. arm of the study.The CONNECT2-EDO51 trial, which is designed to test PepGen’s PGN-EDO51 exon-skipping therapy over 25 weeks in patients with DMD, was placed on hold by the FDA in December. The following month, PepGen disclosed that two patients in the 10-mg/kg cohort had reported asymptomatic magnesium deficiency, although their magnesium levels had since returned to baseline levels after receiving oral magnesium supplements.Now, PepGen has decided to pause the U.K. arm of the study while it considers any lessons from a separate phase 2 study, dubbed CONNECT1, that’s ongoing in Canada. The first two cohorts of the Canadian study have been fully enrolled, with a readout expected in the third quarter. Health Canada has previously been in touch with PepGen to ensure it addressed the regulator’s safety concerns. The company said today that it hasn’t observed any new safety issues in its trials.“With our 10 mg/kg cohort of CONNECT1 study fully enrolled and data expected later this year, we decided to pause CONNECT2 until we are able to review results from the 10 mg/kg cohort in patients with DMD,” PepGen CEO James McArthur, Ph.D., said in the March 4 release.“This will allow us to gather additional safety data, assess the impact of this dose of PGN-EDO51 on dystrophin levels, and potentially improve the design of CONNECT2,” McArthur continued.PepGen will also “rapidly advance” studies of its antisense oligonucleotide therapy PGN-EDODM1 in myotonic dystrophy type 1. A phase 1 trial of the therapy endured its own FDA hold back in 2023 but has since gone on to post what PepGen described last week as “encouraging initial clinical data.”

$PepGen pauses UK arm of DMD trial that\'s already on hold in US$

寡核苷酸临床2期临床1期临床结果

2024-11-22

·阿莫菲克生活

翻来覆去睡不着？也许缺点“镁”问题

睡不着也许是“镁问题” 失眠焦虑改善攻略失眠有可能是身体缺镁了，及时补镁拥有好睡眠~ 1 失眠失眠，是指一个人难以入睡、难以维持睡眠时间和质量或难以体验令人满意的睡眠的病症。这是一种普遍现象，影响着全世界数百万人的生活质量。研究表明，人的一生有1/3时间是在睡眠中度过的，50%以上的人，一生中均有过失眠的经历，失眠不等同于失眠症，偶尔的失眠大家都能接受，长期的失眠易引起心烦易乱、疲乏无力，甚至以头痛、多梦、多汗、记忆力减退等。 2 失眠症状失眠主要表现为入睡困难、夜间频繁醒来、睡眠不连续、早醒、醒后无法入睡等。尽管失眠不会直接危及生命，但它对生活质量和日常功能的影响可能很大。了解失眠的原因、影响和可能的解决方案是改善睡眠质量以及总体生活质量的重要一步。 3 失眠原因失眠的原因分为生理和心理 · 压力和焦虑：日常忧虑和长期的压力情况会导致入睡困难并扰乱睡眠顺序。 · 荷尔蒙变化：荷尔蒙水平的波动，尤其是在怀孕或更年期等时期，会显著影响睡眠模式。 · 慢性疼痛：导致持续疼痛的医疗状况会影响睡眠质量。环境影响 · 卧室的噪音、光线或温度不当等外部因素可能会导致入睡和维持睡眠顺序困难。 · 睡前使用电子设备会让我们暴露在蓝光下，可能会扰乱睡眠和觉醒的自然周期。 4 人生不同阶段时期失眠孕期失眠怀孕会带来显著的生理和情绪变化，从而影响睡眠质量： · 怀孕初期失眠：在最初几周，荷尔蒙变化和尿频可能会干扰持续睡眠。 · 妊娠早期失眠：这一时期的特点是疲劳增加和睡眠困难，通常是由于孕吐和与怀孕相关的焦虑所致。 · 妊娠晚期失眠：随着妊娠的进展，睡眠挑战可能会加剧。怀孕期间腹部的大小、背部疼痛、膝盖疼痛以及排尿次数成为显着的障碍。 · 第九个月失眠：在这个阶段，找到一个舒适的睡姿成为一个真正的挑战，而对分娩的期待会增加焦虑并影响睡眠。产后失眠 · 荷尔蒙显著变化 · 与婴儿护理和夜间喂养有关的睡眠障碍 · 与新父母有关的焦虑和担忧更年期失眠许多女性报告在更年期期间出现睡眠困难，其原因是： · 荷尔蒙变化，尤其是雌激素水平下降 · 潮热和盗汗扰乱睡眠顺序 · 与此时期相关的情绪变化尽管失眠是一种常见现象，但重要的是要了解有有效的解决方案。了解生命任何阶段失眠的具体原因可以实现个性化治疗。通过正确的方法和正确的支持，睡眠质量的显着改善当然是可能的。 5 失眠的影响对身心健康的影响免疫系统： · 睡眠不足会削弱免疫系统，从而增加疾病和感染的风险。 · 研究表明，患有失眠症的人往往在疾病中恢复得更慢。心脏健康： · 长期睡眠不足与心血管疾病的风险增加有关。 · 长期失眠的人会出现血压和心率升高的情况。体重和新陈代谢： · 失眠会破坏调节饥饿感和饱腹感的荷尔蒙平衡。 · 睡眠不足与肥胖和II型糖尿病风险增加之间存在联系。心理健康： · 睡眠不足会增加抑郁和焦虑的风险。 · 失眠会加剧现有的精神状况并使其难以治疗。认知功能： · 损害记忆力、注意力和学习能力。 · 决策和判断能力下降。对日常功能的影响生产力下降： · 难以在工作或学校执行复杂的任务。 · 错误增加以及执行日常任务所需的时间增加。人际关系受损： · 疲劳和不耐烦会影响与家人、朋友和同事的沟通质量。 · 参与社交活动的欲望和精力下降。增加事故风险： · 疲劳会增加车祸和工作事故的风险。 · 研究表明，24 小时不睡觉后驾驶对技能的影响与酒后驾驶类似。 6 失眠如何缓解失眠通常需要采用多系统方法，结合生活方式的改变、自然疗法，有时还需要更先进的解决方案。失眠缓解的一般方法第一是改善睡眠卫生。首先要建立规律的睡眠习惯，创造舒适、黑暗的睡眠环境，并在睡前避免使用电子屏幕。第二定期进行体力活动，最好不要在晚上进行，可以显着改善睡眠质量。此外，减少咖啡因和酒精的摄入，尤其是在下午和晚上，可能有助于改善睡眠。失眠的自然疗法自然疗法也可以在一定程度上缓解失眠的症状。如冥想、深呼吸或瑜伽等放松技巧可以帮助减轻压力，让身心为睡眠做好准备。褪黑激素、缬草或洋甘菊等天然营养补充剂通常被认为是自然治疗选择。还有一种芳香疗法，尤其是薰衣草或佛手柑等精油，也被认为是缓解失眠的自然方法。在枕头下使用草药枕头或香袋有助于营造平静的氛围，促进睡眠。 7 无定形镁对失眠的有效性值得一提的是Amorphica公司提供的创新解决方案。本公司利用纳米非晶矿物的先进技术，开发了一系列支持多种不同医疗状况的产品。无定型钙是这些产品的基础，比普通钙更容易被人体吸收。除了基于无定形钙的产品外，Amorphical 还开发了纳米无定形镁：pH-镁。它提供了一种治疗失眠的创新方法。和无定形钙的技术一样，无定形镁是纳米级的小分子镁，拥有更高的生物利用度。多年来，许多研究已发表，证明镁缺乏与睡眠质量之间存在联系。镁是一种必需矿物质，参与体内许多代谢活动，其中一些与昼夜节律周期有关。昼夜节律周期实际上是人类重要的生物钟，它决定和调节清醒和睡眠的时间。 8 镁的更多用途纳米非晶镁还含有碳酸盐成分，吸收体内氢离子的碳酸盐变成碳酸氢盐。碳酸氢盐是人体的天然酸度平衡。这样，实际上是在非晶态纳米镁中添加了抗炎机制。该产品对于失眠患者的好处是显著的。除了弥补矿物质的缺乏之外，还有平衡酸度和减少炎症的机制。失眠是一种常见现象，影响着全世界数百万人。重要的是我们要了解失眠不仅仅是疲劳的问题。它的影响是深远的，包括损害身心健康、降低日常功能，甚至增加患慢性病的风险。因此，维持良好的生活质量至关重要。 END 关注我们新浪微博：@阿莫菲克

2024-08-19

·drugs

Low Levels of Magnesium Linked to Increased DNA Damage

MONDAY, Aug. 19, 2024 -- Low levels of magnesium with or without high homocysteine (Hcy), are associated with increased DNA damage, according to a study recently published in the European Journal of Nutrition . Varinderpal S. Dhillon, Ph.D., from the University of South Australia in Adelaide, and colleagues examined whether magnesium deficiency alone or in conjunction with Hcy induces DNA damage in vivo in a study involving 172 healthy middle-aged adults. Magnesium, Hcy, folate, and vitamin B 12 blood levels were measured. Three DNA damage biomarkers were examined in peripheral blood lymphocytes: micronuclei (MN), nucleoplasmic bridges (NPBs), and nuclear buds. The researchers observed significant inverse correlations between magnesium and Hcy. Magnesium was positively correlated with folate and vitamin B 12 . Significant inverse correlations were seen for magnesium with MN and NPBs. Compared with those with high magnesium and low Hcy, individuals with low magnesium and high Hcy exhibited a significantly higher frequency of MN and NPBs. An interactive effect was seen between these two factors in induced MN and NPBs. "The results we present regarding the DNA protection effects of magnesium could benefit clinicians and nutritionists in patient counselling regarding food supplementation; if properly implemented, [they] could impact the onset or progression of cancer and other noncommunicable disease," the authors write. Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

临床结果