更新于：2024-11-01

Thyroid Crisis

甲状腺危象

更新于：2024-11-01

基本信息

别名

CRISIS THYROID、Crisis thyroid、Crisis, Thyroid

+ [46]

简介

A dangerous life-threatening hypermetabolic condition characterized by high FEVER and dysfunction of the cardiovascular, the nervous, and the gastrointestinal systems.

关联

项与甲状腺危象相关的药物

Methylthiouracil

甲基硫氧嘧啶

靶点-

作用机制-

在研机构

常州康普药业有限公司

原研机构

常州康普药业有限公司

在研适应症

甲状腺危象

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期1800-01-20

项与甲状腺危象相关的临床试验

JPRN-UMIN000052836 / RecruitingIIT

Japanese multicenter registry of thyroid storm to identify prognostic factors and therapeutic targets. - Japanese thyroid strom registry

开始日期2023-10-16

申办/合作机构-

NCT04879173 / Unknown statusN/AIIT

The Clinical Value of Microvascular Ultrasonography in Real-time Differential Diagnosis of Thyrotoxic Patients Between Hyperthyroidism and Thyroiditis

This study aims to verify the clinical value of thyroid ultrasound with microvascular flow imaging in thyrotoxic patients for differential diagnosis between hyperthyroidism and thyroiditis. We intend to use the RS85 Ultrasound device manufactured by Samsung Medison. Graves' disease and painless thyroiditis/subacute thyroiditis are the main cause of thyrotoxicosis.
Precise discrimination between Graves' disease and painless thyroiditis/subacute thyroiditis is clinically very important in determining treatment methods, such as the prescription of antithyroid drugs. Primary endpoint was to verify the value of vascularity index, defined by Blood pixel in range of image / Total pixel in range of image .Seondary endpoint was to verify the superiority value of Microvascular flow imaging to discriminate thyrotoxicosis patients compared with Color doppler/ Power doppler ultrasound imaging and conventional ultrasound imaging.

开始日期2020-10-14

申办/合作机构

Seoul St. Mary's Hospital

100 项与甲状腺危象相关的临床结果

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100 项与甲状腺危象相关的转化医学

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0 项与甲状腺危象相关的专利（医药）

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1,447

项与甲状腺危象相关的文献（医药）

2024-12-31·Future Science OA

Thyroid storm-induced acute liver dysfunction and portal hypertension in a patient with Graves' disease: a case report

作者: Haouet, Emna ; Yakoubi, Manel ; Khsiba, Amal ; Medhioub, Mouna ; Hamzaoui, Lamine ; Mahmoudi, Moufida ; Mohamed, Asma Ben

Thyroid storm is a life-threatening condition associated with multiorgan dysfunction and decompensation. We report the case of a 41-year-old woman having Graves' disease presented with thyroid storm complicated with liver dysfunction and portal hypertension in the absence of congestive heart failure or known liver disease. After successful therapeutic management, all biological, clinical and morphological abnormalities regressed.

2024-10-01·The American Surgeon™

National Trends and Outcomes in the Operative Management of Thyroid Storm

Article

作者: Wu, James X. ; Seo, Young-Ji ; Benharash, Peyman ; Chervu, Nikhil

Background Thyroid storm is a rare but potentially lethal manifestation of thyrotoxicosis. Guidelines recommend nonoperative management of thyroid storm, but thyroidectomy can be performed if patients fail medical therapy or need immediate resolution of the storm. Outcomes of thyroidectomy for management of thyroid storm remain ill-defined. Methods Using the National Inpatient Sample from 2016 to 2020, a retrospective analysis was conducted of patients admitted with thyroid storm. Outcomes of interest included operative complications and mortality. Multivariable logistic regression was performed to assess factors associated with receiving thyroidectomy and mortality. Results An estimated 16,175 admissions had a diagnosis of thyroid storm. The incidence of thyroid storm increased from .91 per 100,000 people in 2016 to 1.03 per 100,000 people in 2020, with a concomitant increase in mortality from 2.9% to 5.3% ( P < .001). Operative intervention was pursued in 635 (3.9%) cases with a perioperative complication rate of 30%. On multivariable regression, development of acute decompensated heart failure (adjusted odds ratio [AOR] 1.66, 95% Confidence Interval [CI] 1.03-2.68, P = .037) and acute renal failure (AOR 2.10, 95% CI 1.17-3.75, P = .013) increased odds of receiving surgery. The same multivariable model did not show a significant association between thyroidectomy and mortality. Discussion The incidence of thyroid storm and associated mortality increased during the study period. Thyroidectomy is rarely performed during the same admission, with an overall perioperative complication rate of 30% and no effect on mortality. Patients with acute decompensated heart failure and renal failure were more likely to receive an operative intervention.

2024-09-18·JCEM Case Reports

A Case of Refractory Thyroid Storm Despite Correction of Peripheral Thyroid Hormone Levels

Article

作者: Majety, Priyanka ; Evans, Madeline ; Prince, Grace

AbstractThyroid storm is a life-threatening complication of hyperthyroidism that necessitates early diagnosis for aggressive, effective treatment. We present a patient with a newly diagnosed multinodular goiter who presented to the emergency department with leg swelling, dyspnea, tremors, and atrial fibrillation with elevation in thyroid hormone levels consistent with thyrotoxicosis. Despite improvement in peripheral hormone levels on maximized medical treatment with beta-blockers, methimazole, glucocorticoids, cholestyramine, and potassium iodide, she continued to clinically decline with new encephalopathy, heart failure, and liver and kidney dysfunction while receiving treatment. Work-up for alternative causes of her clinical decompensation was unrevealing. Plasmapheresis was initiated, with further reduction in thyroid hormone levels without clinical improvement. Cases in the literature do report incidences of severe thyrotoxicosis refractory to traditional treatment measures; however, generally, these cases involve a failure to reduce thyroid hormone levels with medical treatment and subsequent consideration of plasmapheresis. Our case suggests that clinical improvement in thyroid storm does lag behind biochemical improvement in select patients, and delayed clinical improvement or even severity of symptoms may warrant earlier consideration of plasmapheresis in such patients.