预约演示

更新于：2025-05-07

Firmicute infection

壁厚菌门感染

更新于：2025-05-07

基本信息

别名-

简介-

关联

项与壁厚菌门感染相关的药物

SBX-301

靶点

β-glucuronidase

作用机制

β-glucuronidase抑制剂

在研机构

Symberix, Inc.

原研机构

Symberix, Inc.

在研适应症

壁厚菌门感染 [+1]

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与壁厚菌门感染相关的临床结果

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100 项与壁厚菌门感染相关的转化医学

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0 项与壁厚菌门感染相关的专利（医药）

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项与壁厚菌门感染相关的文献（医药）

2024-01-01·IDCases

Gangrenous cholecystitis due to rare actinomyces odontolyticus infection in patient with pancreatic adenocarcinoma: A case report

Article

作者: Blotevogel, Phillip ; Nahal, Chadi ; Fleetwood, Vidyaratna A. ; Fleetwood, Vidyaratna A ; Fleetwood, Vidya A.

IntroductionGangrenous cholecystitis is a life-threatening complication of acute cholecystitis. Although typically associated with Bacteroides infection, immunocompromised patients, such as those receiving chemotherapy, are more susceptible infection with uncommon organisms. To our knowledge, there are no previously reported cases of gangrenous cholecystitis secondary to actinomyces odontolyticus, which we present here.CaseA 48 year-old male with risk factors for cholecystitis including male sex, ERCP with stent placement, and immunocompromised state secondary to chemotherapy for pancreatic adenocarcinoma presented with worsening abdominal pain and altered mental status. Over the prior 2 months, he had recurrent episodes of abdominal attributed to the pancreatic cancer. Laboratory values were remarkable for leukocytosis and elevated alkaline phosphatase and lactic acid. He was administered antibiotic therapy with piperacillin-tazobactam and urgently underwent a sub-total open cholecystectomy. Intra-abdominal fluid cultures grew actinomyces odontolyticus. In addition to piperacillin-tazobactam, he was subsequently administer vancomycin for clostridium difficile infection and micafungin. De-escalating antibiotics resulted in worsening leukocytosis. Per his previously expressed wishes in the setting of pancreatic cancer, he was discharged to home hospice and expired afterwards.DiscussionThis is the first reported case of gangrenous cholecystitis secondary to infection with actinomyces odontolyticus. The patient's immunosuppressed state made him susceptible to rare organisms and likely delayed the appearance of symptoms, which are also similar to the symptoms of pancreatic cancer causing biliary obstruction. Cholecystitis should be included in the differential diagnosis of epigastric pain for immunocompromised patient with pancreatic cancer and history of ERCP.

2023-09-01·Journal of fish diseases

First identification and histopathological analysis of Lactococcus garvieae infection in whiteleg shrimp, Penaeus vannamei cultured in low salinity water.

Article

作者: Ballantyne, Rolissa ; Lee, Jai-Wei ; Liu, Chun-Hung

The isolation and characterization of bacterial species Lactococcus garvieae, previously unreported in whiteleg shrimp, Penaeus vannamei, has now been identified in the species. The pathogen was recovered from an affected shrimp farm in southern Taiwan. Bacterial characterization first identified the isolate as Gram-positive cocci, and biochemical profiles demonstrated that the causative agent of mortality was 97% L. garvieae. The bacterial cell DNA resulted in amplification of 1522 bp with 99.6% confirmation by PCR analysis. The phylogenetic tree revealed 100% evolutionary similarity among previously isolated strains. Experimental infection further confirmed higher susceptibility of whiteleg shrimp to L. garvieae in waters of lower salinity, particularly 5 ppt, than in higher salinity. Histopathological analysis showed severely damaged hepatopancreas with necrotized, elongated, collapsed tubules, dislodged membranes and granuloma formation in infected shrimp. Transmission electron microscopy observation indicated a hyaluronic acid capsular layer surrounding bacterial cell which is a virulence factor of L. garvieae and likely responsible for immunosuppression and higher mortality of shrimp cultured in lower salinity. Collectively, these findings report the first isolation of L. garvieae from whiteleg shrimp and shed new light on the disease that threatens the highly valuable species and accentuates the need for finding a solution.

2021-12-01·BMC Infectious Diseases3区 · 医学

Case report of an unusual hepatic abscess caused by Actinomyces odontolyticus in a patient with human immunodeficiency virus infection

3区 · 医学

ArticleOA

作者: Chang, Yuan-Chen ; Hsu, Shao-Lun ; Fan, Chia-Kwung ; Wu, Chin-Ting ; Lee, Yuarn-Jang

AbstractBackgroundActinomyces odontolyticus is not commonly recognized as a causative microbe of liver abscess. The detection and identification of A. odontolyticus in laboratories and its recognition as a pathogen in clinical settings can be challenging. However, in the past decades, knowledge on the clinical relevance of A. odontolyticus is gradually increasing. A. odontolyticus is the dominant oropharyngeal flora observed during infancy [Li et al. in Biomed Res Int 2018:3820215, 2018]. Herein we report a case of severe infection caused by A. odontolyticus in an immunocompromised patient with disruption of the gastrointestinal (GI) mucosa.Case presentationWe present a unique case of a patient with human immunodeficiency virus infection who was admitted due to liver abscess and was subsequently diagnosed as having coinfection of A. odontolyticus, Streptococcus constellatus, and Candida albicans during the hospital course. The empirical antibiotics metronidazole and ceftriaxone were replaced with the intravenous administration of fluconazole and ampicillin. However, the patient’s condition deteriorated, and he died 3 weeks later.ConclusionThis report is one of the first to highlight GI tract perforation and its clinical relevance with A. odontolyticus infection. A. odontolyticus infection should be diagnosed early in high-risk patients, and increased attention should be paid to commensal flora infection in immunocompromised individuals.

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