OBJECTIVEAnecdotally, patients with inflammatory articular diseases (IAD) such as psoriatic arthritis (PsA) report weather changes in their symptoms. The objective is to investigate the correlation between weather variation, disease activity (DA) and patients reported outcomes (PROs) in patients with PsA.METHODSHourly measurements of temperature, relative humidity, and pressure were obtained from 2015 to 2020 from Montreal (Environment Canada) and were matched with DA and PROs of PsA patients enrolled in RHUMADATA™. The difference in mean DA and PROs were examined between winter and summer. Pearson Correlation Coefficients were calculated between clinical profile and weather measurements.RESULTSAmong PsA patients, 2665 PROs were collected for a total of 858 patients. The CDAI (p=0.001) and SDAI (p<0.001) were lower in winter. Summer revealed positive correlations between humidity and symptoms (PtGA, fatigue, pain, CRP, BASDAI, BASFI) while negative correlations between temperature and HAQ-DI were reported. In winter, positive correlations were observed between temperature, fatigue, and pain.CONCLUSIONThis is the first study to investigate weather variations through subjective and objective PROs matched with PsA patients. Significant differences in clinical profile were evident between winter and summer and their correlation with weather measurements. However, these distinctions lack clinical significance, which suggests their small impact on PsA patients.