更新于：2024-11-01

Complications of bariatric procedures

减肥手术并发症

更新于：2024-11-01

基本信息

别名

Complications of bariatric procedures、complication of bariatric procedure、complication of bariatric procedure (diagnosis)

简介-

关联

项与减肥手术并发症相关的药物

Glucagon(Xeris Pharmaceuticals, Inc.)

靶点

GCGR

作用机制

GCGR激动剂

在研机构

Tetris Pharma Ltd.初创企业 [+1]

原研机构

Xeris Pharmaceuticals, Inc.

在研适应症

糖尿病 [+1]

非在研适应症

减肥手术并发症 [+4]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2019-09-10

186

项与减肥手术并发症相关的临床试验

IRCT20240826062872N1 / SuspendedN/AIIT

Examination the effect of mobile smartphone self management application on preventing gastrointestinal complications and improving nutritional situation in severely obese patients after bariatric surgery, A pilot study

开始日期2025-03-04

申办/合作机构

Mashhad University of Medical Sciences

NCT06658574 / Not yet recruiting临床2期IIT

Comparative Efficacy of Two Different Oral Dosage Forms of Acetaminophen for Post-operative Analgesia in Bariatric Surgery Patients

Adult patients with morbid obesity who have had Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (LSG) surgery have impaired drug metabolism. There is a paucity of information available on how these patients metabolize acetaminophen post operatively and if drug preparation has any effect on achieving adequate pain control. The surgery may alter the stomach pH, reduce surface area of the stomach, affect transit time, and alter anatomic and physiologic standard absorption of medications. Due to these anatomic and physiologic changes, we seek to understand the potential effects of liquid versus pill formulations of acetaminophen on pain control in this patient population. The purpose of this study is to assess for subjective and objective measures of optimized pain control between formulations of acetaminophen including oral pills and oral liquid.

开始日期2024-11-01

申办/合作机构

Rutgers State University of New Jersey

CTRI/2024/09/073243 / Not yet recruitingN/AIIT

Neutrophil to Lymphocyte Ratio and Platelet to lymphocyte Ratio as a prognostic indicator for Post Operative laparotomy patients in Intensive care unit- A Prospective Observational Study.

开始日期2024-09-30

申办/合作机构

All India Institute of Medical Sciences

100 项与减肥手术并发症相关的临床结果

登录后查看更多信息

100 项与减肥手术并发症相关的转化医学

登录后查看更多信息

0 项与减肥手术并发症相关的专利（医药）

登录后查看更多信息

项与减肥手术并发症相关的文献（医药）

2024-06-01·Georgian medical news

COMPARATIVE ANALYSIS OF EFFECTS INDUCED BY STANDARD AND MODIFIED LAPAROSCOPIC SLEEVE GASTRECTOMY PERFORMANCE ON SHORT TERM AND DISTAL COMPLICATIONS IN PATIENTS WITH 3RD DEGREE OF MORBID OBESITY.

Article

作者: Shahbazyan, S

INTRODUCTIONThe effective techniques of surgical intervention that ensure the desired level of weight reduction outcomes (decreased level of obesity) not always improve QOL outcomes, explained by a range of post-surgery complications. There are the specific complications, strongly impacting the QOL of the patients after bariatric surgery and increasing postoperative comorbidity.AIMThe aim of this retrospective case control study was to evaluate the relative safety of primary LSG performed with standard and modified LSG techniques according to the Clavien-Dindo complication grading system and the rate of long-term complications in patients with BMI>40.MATERIALS AND METHODSA total of 497 cases of patients were divided into 2 groups in accordance with the type of LSG performed. The first group (n = 246) were the patients managed with the Standard protocol of LSG and the second group (n = 251) included the patients treated with the modified protocol of the LSG. The prevalence of specific post-bariatric complications and short-term (30-days) complications was calculated and compared in the groups. The long-term complications were assessed after 1-year օf post-operation period in both intervention groups. The relative risk ratio, p-value and CI95% were calculated for all complications. The short-term (30-days) complications assessment in both intervention groups was performed in accordance with Clavien-Dindo classification of surgical complications.RESULTSThe remarkable reduction of relative risks was registered for the minor and major complications rates. Similarly, the total rates for the minor and major complications demonstrated strong difference between group I and group II (p<0,05). Тhe intraoperative and early (first 72 hours) complications (acute bleeding, and leakage) rates in patients of group I were reliably lower compared to the patients of group II (p<0,05). The RR indicators were 0.123 and 0.121 respectively for acute bleeding and leakage. The indicator of acute obstruction was not essentially different while intergroup comparison was significantly divergent (p<.05). However, the RRR was calculated as 80%. The total rate of intraoperative and first 72 hours complications was 7.3% vs 1.2% in group II. The difference was reliable (p-value<.05) in Gall stone disease, GERD, thrombosis malnutrition and anemia. Comparison of the Renal lithiasis and depression didn't reveal any essential difference between clinical groups (p-value>.05).CONCLUSIONThe results we received are direct confirmation of the comparatively higher effectiveness of the modified LSG evidenced by a significant reduction of the major and minor complications in patients with BMI>40.

2024-05-01·Surgical Endoscopy

Endoscopic closure techniques of bariatric surgery complications: a meta-analysis

Review

作者: Mhaskar, Rahul ; Doyle, William N ; Netzley, Alexander ; Sujka, Joseph ; DuCoin, Christopher ; Docimo, Salvatore ; Ganam, Samer ; Diab, Abdul-Rahman F

BACKGROUNDLeaks following bariatric surgery, while rare, are potentially fatal due to risk of peritonitis and sepsis. Anastomotic leaks and gastro-gastric fistulae following Roux-En-Y gastric bypass (RYGB) as well as staple line leaks after sleeve gastrectomy have historically been treated multimodally with surgical drainage, aggressive antibiotic therapy, and more recently, endoscopically. Endoscopic clipping using over-the-scope clips and endoscopic suturing are two of the most common approaches used to achieve full thickness closure.METHODSA systematic literature search was performed in PubMed to identify articles on the use of endoscopic clipping or suturing for the treatment of leaks and fistulae following bariatric surgery. Studies focusing on stents, and those that incorporated multiple closure techniques simultaneously, were excluded. Literature review and meta-analysis were performed with the PRISMA guidelines.RESULTSFive studies with 61 patients that underwent over-the-scope clip (OTSC) closure were included. The pooled proportion of successful closure across the studies was 81.1% (95% CI 67.3 to 91.7). The successful closure rates were homogeneous (I² = 39%, p = 0.15). Three studies with 92 patients that underwent endoscopic suturing were included. The weighted pooled proportion of successful closure across the studies was shown to be 22.4% (95% CI 14.6 to 31.3). The successful closure rates were homogeneous (I² = 0%, p = 0.44). Three of the studies, totaling 34 patients, examining OTSC deployment reported data for reintervention rate. The weighted pooled proportion of reintervention across the studies was 35.0% (95% CI 11.7 to 64.7). We noticed statistically significant heterogeneity (I² = 68%, p = 0.04). One study, with 20 patients examining endoscopic suturing, reported rate of repeat intervention 60%.CONCLUSIONObservational reports show that patients managed with OTSC were more likely to experience healing of their defect than those managed with endoscopic suturing. Larger controlled studies comparing different closure devices for bariatric leaks should be carried out to better understand the ideal endoscopic approach to these complications.

2023-12-01·Gastroenterology Clinics of North America

Surgical Management of Bariatric Complications and Weight Regain

Review

作者: Higa, Kelvin

The history and evolution of bariatric/metabolic surgical procedures allows for only a brief introduction to complications and surgical approaches for improved weight loss. Our specialty lacks standardization of our operations such as gastric pouch size, intestinal bypass lengths, and consensus on which procedure is best for each individual patient. Anatomic construct as well as adherence to lifestyle modifications can affect short- and long-term outcomes.