RNF43-721(RNF43-721) - _专利_临床

概要

基本信息

药物类型

治疗性疫苗

别名-

靶点-

作用机制-

治疗领域

肿瘤消化系统疾病

在研适应症-

非在研适应症

结直肠癌

原研机构

Tokyo Women's Medical University

在研机构-

非在研机构

Tokyo Women's Medical University

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

1

项与 RNF43-721 相关的临床试验

NCT00677287 / Terminated临床1/2期

Phase I/II Study of Multiple-Vaccine Therapy Using Epitope Peptide Restricted to HLA-A*2402 in Combination With Tegafur/Uracil/Folinate in Treating Patients With Refractory Colorectal Cancer

The purpose of this study is to evaluate the safety and time to progression of HLA-A*2402 restricted epitope peptides RNF43, TOMM34, VEGFR1 and VEGFR2 emulsified with Montanide ISA 51 in combination with Tegafur/Uracil/Folinate chemotherapy.

开始日期2008-05-01

申办/合作机构

University of Tokyo

[+1]

100 项与 RNF43-721 相关的临床结果

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100 项与 RNF43-721 相关的转化医学

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100 项与 RNF43-721 相关的专利（医药）

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1

项与 RNF43-721 相关的文献（医药）

2008-11-01·Gan to kagaku ryoho. Cancer & chemotherapy

[Phase I study of combination therapy with peptide vaccine and anti-cancer drug for colorectal cancer].

Article

作者: Yoshimatsu, Kazuhiko ; Otani, Taisuke ; Fujimoto, Takashi ; Osawa, Gakuji ; Nakamura, Yusuke ; Ogawa, Kenji ; Tsunoda, Takuya ; Yokomizo, Hajime

Phase I study of combination therapy with peptide vaccine and anti-cancer drug for colorectal cancer has been performed in our hospital. The purpose of this study was to evaluate the safety and immune response of different dose of RNF43-721 emulsified with Montanide ISA 51 in combination with S-1/CPT-11 chemotherapy. The study design was a dose escalation of peptide (0.5, 1.0, 3.0 mg) with three patients' cohort. Nine patients were enrolled. All patients were treated with peptide subcutaneously every week and two courses with S-1/CPT-11 chemotherapy. Vaccinations were well tolerated without any major adverse events. Immunological reactions are not analyzed yet. We herein report a case who has been evaluated to be long SD with this intervention for para-aortic LN metastasis from sigmoid colon cancer.

100 项与 RNF43-721 相关的药物交易

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