桑叶提取物(Morus Leaf Extract) - _专利_临床

概要

基本信息

药物类型

中药

别名

Morus indica L. Leaf Extract、Mulberry Leaf Extract

靶点-

作用机制-

治疗领域

内分泌与代谢疾病

在研适应症-

非在研适应症

2型糖尿病

原研机构

University of Mississippi Medical Center

在研机构-

非在研机构

University of Mississippi Medical Center

最高研发阶段无进展临床2/3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

4

项与桑叶提取物相关的临床试验

ISRCTN89882877 / RecruitingN/A

A twelve-week randomised, placebo-controlled study on the effect of Reducose® on glucose, insulin, haemoglobin A1c, satiety, body composition, lipid profile, inflammatory markers and changes in gut microbiome in an overweight population. REMET (Reducose Metabolic Trial)

开始日期2024-10-28

申办/合作机构

Phynova Group Ltd.

[+1]

ITMCTR2024000316 / SuspendedIIT

Effects of mulberry leaf extract on blood glucose and insulin in healthy people

开始日期2024-08-30

申办/合作机构

南京医科大学附属苏州医院

NCT06488326 / Not yet recruitingN/AIIT

Effect of Mulberry Leaf Extract Capsule on Blood Glucose Control in Healthy Volunteers

Volunteers will be divided into 4 groups which are mulberry leaf extract 6 mg capsule, mulberry leaf extract 12 mg capsule, mulberry leaf extract 18 mg capsule, and placebo capsule group. They will be tested blood glucose levels (taken from the fingertips) before starting. Then, they will take 1 capsule of the sample one time. After taking the sample for 30 minutes, they will take 50 g of sucrose in 250 ml of water in 5 minutes. Then, they will be tested blood glucose levels (taken from the fingertips) at 30, 60, 90, and 120 minutes.

开始日期2024-07-01

申办/合作机构

University of Chulalongkorn

[+1]

100 项与桑叶提取物相关的临床结果

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100 项与桑叶提取物相关的转化医学

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100 项与桑叶提取物相关的专利（医药）

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20

项与桑叶提取物相关的文献（医药）

2024-01-15·Cureus

A Systematic Review of the Efficacy and Safety of Mulberry Formulations for Chemotherapy- and/or Radiotherapy-Induced Oral Mucositis

Review

作者: Shabana, Shaik ; Tanvi, Khandekar ; Asha, V ; Arvind, Muthukrishnan ; Sowbhagya Lakshmi, A ; Ananta, Gimre ; Raghunand Sindhe, J

Oral mucositis (OM) is one of the common side effects of radiotherapy and chemotherapy. It is an extremely painful condition characterized by erythema, edema, and ulceration of the oral mucosa. Many plant-based and chemical formulations are used to prevent OM. The aim of the study is to evaluate the efficacy and safety of different black mulberry formulations in chemotherapy and/or radiotherapy-induced OM. A systematic search was performed using PubMed, Excerpta Medica database (Embase), the Cochrane Library, and Web of Science databases for articles published until March 2023. We have included studies conducted on people undergoing chemotherapy and/or radiotherapy and compared the effect of any mulberry formulation with other interventions. Out of 30 articles retrieved, four articles with a cumulative sample size of (N = 297) were included in the review. Mulberry formulations were compared with no intervention, grape molasses, chlorhexidine, and sodium bicarbonate. Out of the four articles, in three articles, mulberry formulations showed a significant decrease in grade 2 and grade 3 OM and also showed better prevention of OM as compared to the other intervention and control groups, and in one article, the grape molasses was more preventive for the occurrence of OM. Mulberry showed a significant decrease in dry mouth. Mulberry showed more improvement in the pain score and quality of life. The incidence and severity were lower in the mulberry group than in other interventions. One article showed less weight loss, and another article showed gradual weight gain from the use of mulberries. From this, we conclude that mulberry is effective for the treatment of OM. Mulberry also shows improvement in the pain score and quality of life.

2022-12-01·Journal of Clinical Pharmacy and Therapeutics

Impact of mulberry consumption on cardiometabolic risk factors: A systematic review and meta‐analysis of randomized‐controlled trials

Review

作者: Chen, Xibin ; Nateghi, Mahsa ; Sohouli, Mohammad Hassan ; Melekoglu, Ebru ; Fatahi, Somaye

OBJECTIVEThe current study aimed to comprehensively evaluate the potential effects of mulberry consumption on cardiometabolic risk factors in adults.METHODSRelevant articles published up to January 2021 were systematically retrieved from SCOPUS, PubMed/MEDLINE, EMBASE, and Web of Science databases. We included all randomized controlled trials (RCTs) investigating the impact of mulberry consumption on various cardiometabolic risk factors.RESULTSThe quantitative meta-analysis of 12 eligible RCTs demonstrated a significant reducing effect of mulberry consumption on haemoglobin A1c (HbA1c) (weighted mean difference [WMD]: -0. 55, 95% CI: -1.08, -0.02, p = 0.044), serum total cholesterol (TC) (WMD: -13.13 mg/dl, 95% CI: -19.06, -7.20, p < 0.001), low-density lipoprotein levels (LDL-C) (WMD: -8.84 mg/dl, 95% CI: -13.26, -4.42, p < 0.001), triglycerides (TG) (WMD: -19.67 mg/dl, 95% CI: -30.13, -9.22, p < 0.001) and C-reactive protein (CRP) (WMD: -1.60, mg/L, 95% CI: -3.07, -0.12, p = 0.034). Also, >300 mg daily intake of mulberry exhibited a favourable effect on serum high-density lipoprotein levels (HDL-C). However, there were no significant differences between mulberry intervention and control groups for other factors.CONCLUSIONThe current systematic review and meta-analysis revealed that incorporating mulberry into the diet may favourably affect several cardiometabolic risk factors.

2021-04-01·Poultry Science

Mulberry leaf polysaccharide supplementation contributes to enhancing the respiratory mucosal barrier immune response in Newcastle disease virus–vaccinated chicks

作者: Chen, Xiaolan ; Yang, Haifeng ; Jia, Jiping ; Chen, Yu ; Jiang, Chunmao ; Chen, Haifeng ; Wang, Jing

100 项与桑叶提取物相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
2型糖尿病	临床3期	美国	University of Mississippi Medical Center	2008-04-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00795704 (Mul-DM, CTgov)	临床2/3期	2型糖尿病	24	Placebo (Placebo)	(鹹積齋憲製鏇簾夢鏇醖) = 衊鹹鹽衊蓋糧觸構觸醖窪網壓鬱繭衊觸選艱膚 (築觸廠襯醖糧觸構壓廠, 餘淵遞獵艱窪顧鹹窪鬱 ~ 淵網構淵範獵顧壓簾顧) 更多	-	2012-08-09
				Mulberry Leaf Extract (Mulberry Leaf Extract)	(鹹積齋憲製鏇簾夢鏇醖) = 觸遞憲積願齋網鏇構淵窪網壓鬱繭衊觸選艱膚 (築觸廠襯醖糧觸構壓廠, 淵築壓餘觸齋鏇醖鑰窪 ~ 積顧蓋簾遞憲選醖顧鏇) 更多