Effect of Mulberry Leaf Extract on Glycemic Durability in Non-insulin Dependent Diabetes Mellitus: a Double-blind, Randomized, Placebo-controlled Pilot Study (Mul-DM)

The purpose of this study is to evaluate whether mulberry leaf extract will help control blood sugar in patients with type 2 diabetes. We also want to look at the safety of mulberry leaf extract in these patients.

开始日期2008-04-01

申办/合作机构

University of Mississippi Medical Center

100 项与桑叶提取物相关的临床结果

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100 项与桑叶提取物相关的转化医学

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100 项与桑叶提取物相关的专利（医药）

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项与桑叶提取物相关的文献（医药）

2024-01-15·Cureus

A Systematic Review of the Efficacy and Safety of Mulberry Formulations for Chemotherapy- and/or Radiotherapy-Induced Oral Mucositis

Review

作者: Shabana, Shaik ; Tanvi, Khandekar ; Asha, V ; Arvind, Muthukrishnan ; Ananta, Gimre ; Sowbhagya Lakshmi, A ; Raghunand Sindhe, J

Oral mucositis (OM) is one of the common side effects of radiotherapy and chemotherapy. It is an extremely painful condition characterized by erythema, edema, and ulceration of the oral mucosa. Many plant-based and chemical formulations are used to prevent OM. The aim of the study is to evaluate the efficacy and safety of different black mulberry formulations in chemotherapy and/or radiotherapy-induced OM. A systematic search was performed using PubMed, Excerpta Medica database (Embase), the Cochrane Library, and Web of Science databases for articles published until March 2023. We have included studies conducted on people undergoing chemotherapy and/or radiotherapy and compared the effect of any mulberry formulation with other interventions. Out of 30 articles retrieved, four articles with a cumulative sample size of (N = 297) were included in the review. Mulberry formulations were compared with no intervention, grape molasses, chlorhexidine, and sodium bicarbonate. Out of the four articles, in three articles, mulberry formulations showed a significant decrease in grade 2 and grade 3 OM and also showed better prevention of OM as compared to the other intervention and control groups, and in one article, the grape molasses was more preventive for the occurrence of OM. Mulberry showed a significant decrease in dry mouth. Mulberry showed more improvement in the pain score and quality of life. The incidence and severity were lower in the mulberry group than in other interventions. One article showed less weight loss, and another article showed gradual weight gain from the use of mulberries. From this, we conclude that mulberry is effective for the treatment of OM. Mulberry also shows improvement in the pain score and quality of life.

2022-12-01·Journal of Clinical Pharmacy and Therapeutics

Impact of mulberry consumption on cardiometabolic risk factors: A systematic review and meta‐analysis of randomized‐controlled trials

Review

作者: Chen, Xibin ; Nateghi, Mahsa ; Sohouli, Mohammad Hassan ; Melekoglu, Ebru ; Fatahi, Somaye

OBJECTIVEThe current study aimed to comprehensively evaluate the potential effects of mulberry consumption on cardiometabolic risk factors in adults.METHODSRelevant articles published up to January 2021 were systematically retrieved from SCOPUS, PubMed/MEDLINE, EMBASE, and Web of Science databases. We included all randomized controlled trials (RCTs) investigating the impact of mulberry consumption on various cardiometabolic risk factors.RESULTSThe quantitative meta-analysis of 12 eligible RCTs demonstrated a significant reducing effect of mulberry consumption on haemoglobin A1c (HbA1c) (weighted mean difference [WMD]: -0. 55, 95% CI: -1.08, -0.02, p = 0.044), serum total cholesterol (TC) (WMD: -13.13 mg/dl, 95% CI: -19.06, -7.20, p < 0.001), low-density lipoprotein levels (LDL-C) (WMD: -8.84 mg/dl, 95% CI: -13.26, -4.42, p < 0.001), triglycerides (TG) (WMD: -19.67 mg/dl, 95% CI: -30.13, -9.22, p < 0.001) and C-reactive protein (CRP) (WMD: -1.60, mg/L, 95% CI: -3.07, -0.12, p = 0.034). Also, >300 mg daily intake of mulberry exhibited a favourable effect on serum high-density lipoprotein levels (HDL-C). However, there were no significant differences between mulberry intervention and control groups for other factors.CONCLUSIONThe current systematic review and meta-analysis revealed that incorporating mulberry into the diet may favourably affect several cardiometabolic risk factors.

2021-04-01·Poultry Science

Mulberry leaf polysaccharide supplementation contributes to enhancing the respiratory mucosal barrier immune response in Newcastle disease virus–vaccinated chicks

作者: Chen, Xiaolan ; Yang, Haifeng ; Jia, Jiping ; Chen, Yu ; Jiang, Chunmao ; Chen, Haifeng ; Wang, Jing

100 项与桑叶提取物相关的药物交易

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00795704 (CTgov)	临床2/3期	2型糖尿病 \| 肌肝脑眼侏儒症	24	Placebo (Placebo)	(鹹鹹網獵繭網鹽遞構觸) = 範艱簾顧襯壓繭鹽廠簾範觸齋簾簾憲觸網積簾 (餘遞糧餘繭鑰簾遞築夢, 鹹膚積鹹繭繭網選獵糧 ~ 網顧醖構餘鑰餘憲選艱) 更多	-	2012-08-09
				Mulberry Leaf Extract (Mulberry Leaf Extract)	(鹹鹹網獵繭網鹽遞構觸) = 構醖築餘鹹淵餘餘鬱憲範觸齋簾簾憲觸網積簾 (餘遞糧餘繭鑰簾遞築夢, 艱製鏇憲製壓簾製齋襯 ~ 齋鑰繭顧遞觸壓夢選鹹) 更多