S. aureus combined vaccine(University of Chicago)(S. aureus combined vaccine(University of Chicago)) - 在研适应症：金黄色葡萄球菌感染_专利_临床

概要

基本信息

药物类型

联合疫苗、预防性疫苗

别名-

靶点-

作用方式-

作用机制-

治疗领域

感染

在研适应症

金黄色葡萄球菌感染

非在研适应症-

原研机构

The University of Chicago

在研机构

The University of Chicago

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 S. aureus combined vaccine(University of Chicago) 相关的临床结果

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100 项与 S. aureus combined vaccine(University of Chicago) 相关的转化医学

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100 项与 S. aureus combined vaccine(University of Chicago) 相关的专利（医药）

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1

项与 S. aureus combined vaccine(University of Chicago) 相关的文献（医药）

2006-11-07·Proceedings of the National Academy of Sciences1区 · 综合性期刊

Vaccine assembly from surface proteins ofStaphylococcus aureus

1区 · 综合性期刊

Article

作者: Stranger-Jones, Yukiko K. ; Bae, Taeok ; Schneewind, Olaf

Staphylococcus aureusis the most common cause of hospital-acquired infection. Because of the emergence of antibiotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins ofS. aureusas antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, SdrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinicalS. aureusisolates.

100 项与 S. aureus combined vaccine(University of Chicago) 相关的药物交易

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