A Dose-response Study With Strontium Malonate in Postmenopausal Women. A 12 Week, Multi National, Double Blind, Randomized, 5 Arms, Parallel Group Placebo Controlled Open Label Active Controlled, Phase II Study With 3 Dose Levels of Strontium Malonate and Protelos Within Post Menopausal Women With a BMDT-score Below -1

The primary objective of the study is to compare dose-response effect of three dose levels of strontium malonate to placebo on bone resorption quantified by S-CTX-1 following 12 weeks of treatment.

开始日期2006-12-01

申办/合作机构

Osteologix Holdings Plc

100 项与 Strontium Malonate 相关的临床结果

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100 项与 Strontium Malonate 相关的转化医学

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100 项与 Strontium Malonate 相关的专利（医药）

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20,506

项与 Strontium Malonate 相关的文献（医药）

2025-09-01·JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Comprehensive quality evaluation of Huricha Liuwei Pills using multidimensional fingerprinting and multicomponent quantification

Article

作者: Chen, Lingkui ; Zhang, Zhenwei ; Lan, Lili ; Yang, Sha ; Bao, Mengfan ; Cai, Ming ; Sun, Wanyang ; Sun, Guoxiang

In recent years, the application of traditional Chinese medicine (TCM) has gradually increased in the world, the study of quality control has become more and more important. As a branch of TCM, Mongolian medicine has complex compositions and lacks research on the overall quality. Therefore, in this paper, three fingerprints, high performance liquid chromatography (HPLC), differential scanning calorimetry (DSC) and electrochemical (EC), were established using Huricha Liuwei pills (HLP) as an example, and the quality of the three fingerprints was evaluated by the comprehensive ratio quantitative fingerprint method (CRQFM). To ensure the accuracy of the quantitative analysis, the purity of the fingerprint peaks was verified using the dual-wavelength absorption coefficient ratio (DWACR). And four components were quantified by the multi-markers assay by monolinear method (MAML): gallic acid (GA), chlorogenic acid (CA), hydroxysafflor yellow A (HSYA) and ellagic acid (EA). Based on the EC redox characteristics, the fingerprint efficacy relationship between two fingerprints (HPLC and DSC) and EC activity was established. The results showed that after CRQFM evaluation, 16 batches of samples were categorized into different quality grades. Subsequently, the evaluation results were integrated using the equal weighing method, and the 16 batches of samples had quality grades ranging from 1 to 3. The fingerprint efficacy relationship indicated that more than half of the fingerprint peaks showed good antioxidant activity, including GA, CA and EA. This paper established an effective quality control method for HLP and provided new ideas for the quality evaluation of other TCM.

2025-09-01·AQUACULTURE

Hypoxic stress divergence time and metabolism-associated gut microbiome signatures — The strategy is to oxygenate for fat greenling (Hexagrammos otakii)

作者: Liu, Yuan ; Peng, Lei ; Zhan, Yu ; Gao, Dongxu ; Liu, Rangman ; Wang, Wei ; Su, Junru ; Wu, Yiting ; Zhao, Ling ; Xue, Zhuang ; Zhang, Xinying

Hypoxic stress has always been closely related to the physiol. of fishes, but the impacts on the gut microbiota and metabolism have not been fully resolved.In this study, we analyzed the interaction between gut microbiota and host metabolism during hypoxic stress, and reveal the mechanism of growth retardation in fat greenling (Hexagrammos otakii) subjected to hypoxic stress over time.During ongoing hypoxic stress, the oxidative stress and inflammation responses significantly increased over three days compared to the control group, and these changes were restored over fifteen days.Next, we characterized changing microbial communities at different periods of hypoxic stress, and validated the communities for different fish groups subjected to hypoxic stress, based on which we found the temporal dynamics of gut microbiota.Among groups subjected to hypoxic stress, increased inflammatory (IL-1β and TNF-α) response was associated with sphingosine-1-phosphate (metabolites) and Aliivibrio (microbiota) through three days of hypoxia, as compared to the control group and individuals with shorter hypoxic stress (12h).This pattern under extended hypoxic stress (15 days) suggested that arginine and Exiguobacterium play regulating roles during the adaptation process (7-9 days) in H. otakii.These results have important implications for the understanding of the effects of aquaculture and environmental conditions upon H. otakii and offer potential contributions to an ongoing assessment of hypoxic effects upon fishery resources.

2025-09-01·TALANTA

First truly deep eutectic solvent (DES) based stationary phase for high-performance liquid chromatography (HPLC)

Article

作者: Przyjazny, Andrzej ; Marchel, Mateusz ; Boczkaj, Grzegorz

Deep eutectic solvents (DESs) have gained significant attention due to their environmentally friendly properties and versatile applications in various fields, including analytical chemistry. This study investigates the use of a deep eutectic solvent (DES) composed of l-proline protonated with hydrochloric acid and xylitol as a surface modifier for silica-based stationary phases in high-performance liquid chromatography (HPLC). The DES was successfully immobilized on silica, and its impact on chromatographic performance was evaluated in normal-phase liquid chromatography (NP-HPLC). It was observed that DES immobilized layer acted as a real liquid stationary phase. The DES-modified columns exhibited improved selectivity, resolution for polar analytes, and shorter retention times for non-polar compounds compared to unmodified silica columns. Additionally, the DES-modified phase demonstrated long-term stability over multiple chromatographic cycles. These results highlight the potential of DESs as customizable, environmentally friendly stationary phase modifiers for enhancing chromatographic efficiency and selectivity, particularly in separating polar analytes, opening new avenues for the development of advanced chromatographic materials and contributing to greener and more efficient separation techniques. The robust preparation method also facilitates easy scalability for large-scale applications, such as the isolation of valuable compounds and the purification of complex mixtures, including phenols, amines, and nitro-derivatives.

100 项与 Strontium Malonate 相关的药物交易

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