AC-25793(AC-25793) - 药物靶点：BDNF x TrkA x TrkB x p75NTR_在研适应症：阿尔茨海默症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

NGF/TrkA and BDNF/TrkB signaling enhancer (AlzeCure)

靶点

BDNF x TrkA x TrkB x p75NTR

作用机制

BDNF调节剂(脑源性神经营养因子调节剂)、TrkA 激活剂(神经生长因子受体Trk-A 激活剂)、TrkB刺激剂(神经营养性酪氨酸激酶受体-2型刺激剂)

+ [1]

治疗领域

神经系统疾病

在研适应症

阿尔茨海默症

非在研适应症-

原研机构

AlzeCure Pharma AB

在研机构

AlzeCure Pharma AB

Karolinska Institutet

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 AC-25793 相关的临床结果

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100 项与 AC-25793 相关的转化医学

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100 项与 AC-25793 相关的专利（医药）

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1

项与 AC-25793 相关的文献（医药）

2010-05-01·Journal of Molecular Neuroscience3区 · 医学

Nerve Growth Factor-Induced Protection of Brain Capillary Endothelial Cells Exposed to Oxygen–Glucose Deprivation Involves Attenuation of Erk Phosphorylation

3区 · 医学

Article

作者: Hadar Arien-Zakay ; Cezary Marcinkiewicz ; Philip Lazarovici ; Shimon Lecht ; Peter I. Lelkes

Nerve growth factor (NGF) was recently characterized as an angiogenic factor inducing proliferation, migration, and capillary sprouting in endothelial cells (ECs) of different vascular beds. While NGF neuroprotective effects on neurons were described, its survival-inducing effects on brain capillary ECs were not yet addressed. Using a model of oxygen-glucose deprivation (OGD) followed by reoxygenation, we demonstrated that NGF conferred protection in brain capillary ECs. These cells express TrkA and p75(NTR) receptors and respond to NGF by stimulation of Erk1/2 phosphorylation and stimulation of proliferation and migration. The NGF protective effect was dose-dependent, inhibited by NGF/TrkA antagonist, K252a, and required presence of NGF during both OGD and reoxygenation phases while the major protective effect was related to decreased cell death during the reoxygenation phase. A causal relationship was found between NGF-induced protection and attenuation of OGD-induced Erk1/2 phosphorylation, supporting the death-promoting role of insult-induced Erk1/2 phosphorylation in the brain capillary ECs. These results emphasize the importance of NGF in the process of EC survival in response to ischemic injury and suggest fine-tuning regulation of Erk1/2 phosphorylation, extending the neuroprotective impact of NGF from sympathetic neuroendocrine cells to brain capillary ECs as the other element in the neurovascular tandem.

100 项与 AC-25793 相关的药物交易

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