Arsenic is one of the largest mass poisonings in Bangladesh. Arsenic keratosis of the palm and sole is a common feature of arsenicosis. Brinjal or eggplant ubiquitous vegetable found in different parts of the world, including Bangladesh, scientifically known as Solanum melongena. A study showed ointment containing crude extract of Solanum melongena peel origin is effective in arsenic keratosis. Solasodine is one of the active compounds of Solanum melongena peel. In the current study, an ointment containing a single compound solasodine isolated from Solanum melongena peel . The ointment made from solasodine extract was distributed among arsenic keratosis patients to see the effect.

开始日期2018-09-23

申办/合作机构

Bangabandhu Sheikh Mujib Medical University

100 项与澳洲茄胺相关的临床结果

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100 项与澳洲茄胺相关的转化医学

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100 项与澳洲茄胺相关的专利（医药）

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205

项与澳洲茄胺相关的文献（医药）

2024-08-01·Naunyn-Schmiedeberg's Archives of Pharmacology

Revisiting the ethnomedicinal, ethnopharmacological, phytoconstituents and phytoremediation of the plant Solanum viarum Dunal

Review

作者: Kuca, Kamil ; Kumar, Dinesh ; Dhalaria, Rajni ; Azizov, Shavkatjon ; Das, Priyanku Pradip ; Kumar, Deepak ; Kumar, Ajay ; Verma, Rachna ; Thakur, Mehak

Solanum viarum, a perennial shrub, belongs to the family Solanaceae known for its therapeutic value worldwide. As a beneficial remedial plant, it is used for treating several disorders like dysentery, diabetes, inflammation, and respiratory disorders. Phytochemistry studies of this plant have shown the presence of steroidal glycoside alkaloids, including solasonine, solasodine, and solamargine. It also has flavonoids, saponins, minerals, and other substances. S. viarum extracts and compounds possess a variety of pharmacological effects, including antipyretic, antioxidant, antibacterial, insecticidal, analgesic, and anticancer activity. Most of the heavy metals accumulate in the aerial sections of the plant which is considered a potential phytoremediation, a highly effective method for the treatment of metal-polluted soils. We emphasize the forgoing outline of S. viarum, as well as its ethnomedicinal and ethnopharmacological applications, the chemistry of its secondary metabolites, and heavy metal toxicity. In addition to describing the antitumor activity of compounds and their mechanisms of action isolated from S. viarum, liabilities are also explained and illustrated, including any significant chemical or metabolic stability and toxicity risks. A comprehensive list of information was compiled from Science Direct, PubMed, Google Scholar, and Web of Science using different key phrases (traditional use, ethnomedicinal plants, western Himalaya, Himachal Pradesh, S viarum, and biological activity). According to the findings of this study, we hope that this review will inspire further studies along the drug discovery pathway of the chemicals extracted from the plant of S. viarum. Further, this review shows that ethnopharmacological information from ethnomedicinal plants can be a promising approach to drug discovery for cancer and diabetes.

2024-08-01·Experimental Cell Research

Solasodine targets NF-κB signaling to overcome P-glycoprotein mediated multidrug resistance in cancer

Article

作者: Pore, Pranjali Milind ; Prasad, N Rajendra ; Bharathiraja, Pradhapsingh ; Govindasamy, Chandramohan ; Balamurugan, Karankumar

P-glycoprotein (P-gp) mediated multidrug resistance (MDR) is the leading cause of chemotherapy failure since it causes the efflux of chemotherapeutic drugs from the cancer cells. Solasodine, a steroidal alkaloid and oxaspiro compound, present in the Solanaceae family showed significant cytotoxic effects on various cancer cells. However, the effect of solasodine on reversing P-gp mediated drug resistance is still unknown. Primarily in this study, the integrative network pharmacology analysis found 71 common targets between solasodine and cancer MDR, among them NF-κB was found as a potential target. The results of immunofluorescence analysis showed that solasodine significantly inhibits NF-κB-p65 nuclear translocation which caused downregulated P-gp expression in KBChR-8-5 cells. Further, solasodine binds to the active sites of the TMD region of P-gp and inhibits P-gp transport activity. Moreover, solasodine significantly promotes doxorubicin intracellular accumulation in the drug resistant cells. Solasodine reduced the fold resistance and synergistically sensitized doxorubicin's therapeutic effects in KBChR-8-5 cells. Additionally, the solasodine and doxorubicin combination treatment increased the apoptotic cell populations and G2/M phase cell cycle arrest in KBChR-8-5 cells. The MDR tumor bearing xenograft mice showed tumor-suppressing characteristics and P-gp downregulation during the combination treatment of solasodine and doxorubicin. These results indicate that solasodine targets NF-κB signaling to downregulate P-gp overexpression, inhibit P-gp transport activity, and enhance chemosensitization in MDR cancer cells. Considering its multifaceted impact, solasodine represents a potent natural fourth-generation P-gp modulator for reversing MDR in cancer.

2024-07-01·Chemistry & Biodiversity

New Solasodine‐Type Glycoalkaloids Isolated from Solanum nigrum and Their Cytotoxic Activity

Article

作者: Luyen, Bui Thi Thuy ; Trang, Bui Thi Thu

AbstractThree undescribed solalodine‐type glycoalkaloids, named solanigrinoside A−C (1–3), and six known compounds (4–9) were isolated from the whole plants of Solanum nigrum. Their structures were elucidated based on analysis of HR‐ESI‐MS, 1D‐ and 2D‐NMR spectral data, and comparison with those reported in literatures. The solanigrinoside A−C (1–3), solasodine (4), and 3‐acetoxysolasodine (5) exhibited cytotoxic effects against LU‐1, Hep‐G2, and MCF‐7 cells with IC50 values in range from 4.6 μM to 56.2 μM. Compound 2 showed the significant cytotoxic activity with corresponding IC50 values of 5.7 μM, 7.9 μM, and 4.6 μM, respectively.

100 项与澳洲茄胺相关的药物交易

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