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更新于：2025-08-09
Bangabandhu Sheikh Mujib Medical University
更新于：2025-08-09
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NCT07087366
Enhanced Recovery After Surgery(ERAS) Pathway Following Gynecological Oncology Surgery in a Tertiary Level Hospital:A Prospective Randomized Controlled Trial
NCT07059572
Comparative Evaluation of Guava Leaf Extract and Chlorhexidine Mouthwash in Patients With Chronic Gingivitis
NCT07008846
Efficacy of Tofacitinib, Methotrexate Combination Therapy Versus Upadacitinib, Methotrexate Combination Therapy in Moderate to Severe Rheumatoid Arthritis
100 项与 Bangabandhu Sheikh Mujib Medical University 相关的临床结果
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2025-09-01JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
“Wish to Die” Among Patients With Advanced Cancer: Does Institutional Quality of Care Matter?
Article
作者: Rahman, Rubaiyat ; Palat, Gayatri ; Hapuarachchi, Thushari ; Kapol, Nattiya ; Balasubramanian, Ishwarya ; Malhotra, Chetna ; Joad, Anjum Khan ; Ozdemir, Semra ; Manalo, Maria Fidelis ; Chaudhry, Isha ; Zu, Wah Wah Myint ; Tuong, Pham Nguyen ; Andres, Ellie Bostwick
CONTEXT:
Provision of quality care may diminish expression of wish to die (WTD), but this relationship has not been empirically assessed.
OBJECTIVES:
To assess the association between institutional quality of care and expression of WTD among patients with advanced cancer.
METHODS:
We surveyed patients with advanced cancer from 9 hospitals in 8 low- and middle- income countries (Bangladesh, China, India, Thailand, the Philippines, Myanmar, Sri Lanka and Vietnam). We estimated mixed-effects logistic regression model to assess the relationship between patient and provider reported quality of care with WTD.
RESULTS:
12.4% of patients in our sample (N = 1648) expressed a WTD, with rates varying between 2% and 45% across institutions. Patients who reported better care coordination (OR:0.63, 95% CI: [0.45,0.89] and nursing care (OR: 0.63, 95% CI: [0.45,0.87]) had lower odds, whereas those reporting better physician communication had higher odds of a expressing a WTD (OR: 1.99, 95% CI: [1.40,2.81]). Patients receiving care at institutions permitting longer durations of morphine prescriptions (OR: 0.96, 95% CI: [0.93,0.99]), those at institutions with a higher proportion of specialist palliative care physicians per 1000 advanced cancer patients treated monthly (OR: 0.97, 95% CI: [0.96,0.99]), and those treated at institutions conducting satisfaction surveys (OR: 0.41, 95% CI: [0.25,0.67]), were less likely to express a WTD.
CONCLUSION:
Findings underscore that institutional quality of care is associated with reduced likelihood of patients expressing a WTD. Thus, enhancing institutional care quality - particularly improving access to palliative care - is critical for bettering the care of terminally ill.
2025-08-01CLINICA CHIMICA ACTA
Genetic landscape of primary ovarian insufficiency in Bangladeshi women through whole exome sequencing
Article
作者: Mim, Rabeya Akter ; Hasan, Md Nahid ; Nassir, Nasna ; Uddin, Mohammed ; Kazal, Rezaul Karim ; Pervin, Hasna Hena ; Eshaque, Tamannyat Binte ; Gutgutia, Rohit ; Akter, Hosneara ; Omar, Farjana Binta ; Rahaman, Md Atikur ; Islam, Amirul ; Ganguly, Athoi ; Hossain, Mohammad Shahnoor
BACKGROUND:
Primary Ovarian Insufficiency (POI), a significant cause of female infertility, involves premature ovarian dysfunction before the age of 40 and is influenced by genetic predispositions, autoimmune disorders, environmental factors, and metabolic changes. In this study, we employed Whole Exome Sequencing (WES) to explore genetic variations linked to POI in Bangladeshi women.
MATERIALS AND METHODS:
This study encompassed 30 Bangladeshi women aged 16 to 40 diagnosed with POI. The diagnosis was based on clinical criteria, including elevated Follicle-Stimulating Hormone levels and a history of at least four months of oligomenorrhea or amenorrhea. WES was performed on POI cases and used population specific internal cohort to filter out and identify genes impacting ovarian function. Subsequently, Sanger Sequencing was used to validate pathogenic or likely pathogenic variants.
RESULTS:
We detected seven pathogenic variants in 23% of all POI cases (7/30) across six genes: Thyroglobulin (TG), Thyroid-Stimulating Hormone Receptor (TSHR), tubulin beta 8 class viii (TUBB8), PR/SET domain 9 (PRDM9), required for meiotic nuclear division 1 homolog (RMND1), and homologous recombination factor with OB-fold (HROB). Two novel likely pathogenic variants were identified, including a heterozygous frameshift variant in TG (p.H209Pfs11) and a heterozygous missense variant in TSHR (p.T1904C). Additionally, variants of uncertain significance were found in 63% (19/30) of the cases, with seven being novel. Incidental findings of pathogenic variants were observed in several genes, with Hemoglobin subunit Beta (HBB) being the most common.
CONCLUSIONS:
This study highlights the utility of whole exome sequencing in identifying genetic risk factors for POI, suggesting that incorporating genetic screening into routine clinical practice could improve diagnostic and therapeutic strategies, particularly in regions lacking genomic data on this condition.
2025-08-01Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
World federation of interventional and therapeutic neuroradiology (WFITN) federation assembly neurointerventional surgery safety checklist
Review
作者: Siddiqui, Adnan H ; Mahadevan, Jeyaledchumy ; Kulcsar, Zsolt ; Manfre, Luigi ; Garbugino, Silvia ; de Freitas, Carlos ; Mont’Alverne, Francisco ; Kocer, Naci ; Mocco, J ; Dey, Subash Kanti ; Agid, Ronit ; Lee, Wickly ; Orbach, Darren B ; Churojana, Anchalee ; Chryssidis, Steve ; Wang, Donghai ; Desal, Hubert ; Chen, Michael ; Ayudya, Sirintara Singhara Na ; Petrocelli, Sergio ; LeFeuvre, David ; De Villiers, Laetitia ; Yoon, Woong ; Rahman, Mohibur ; Matsumaru, Yuji ; Fargen, Kyle M ; Suh, Sang Hyun ; Anil, Gopinathan ; Taylor, Allan ; Januel, Anne ; Miyachi, Shigeru ; Tanaka, Michihiro ; Zhang, Hongqi ; Caroff, Jildaz ; Harrichandparsad, Rohen
Over the last 10 years, there has been a rise in neurointerventional case complexity, device variety and physician distractions. Even among experienced physicians, this trend challenges our memory and concentration, making it more difficult to remember safety principles and their implications. Checklists are regarded by some as a redundant exercise that wastes time, or as an attack on physician autonomy. However, given the increasing case and disease complexity along with the number of distractions, it is even more important now to have a compelling reminder of safety principles that preserve habits that are susceptible to being overlooked because they seem mundane. Most hospitals have mandated a pre-procedure neurointerventional time-out checklist, but often it ends up being done in a cursory fashion for the primary purpose of ‘checking off boxes’. There may be value in iterating the checklist to further emphasize safety and communication. The Federation Assembly of the World Federation of Interventional and Therapeutic Neuroradiology (WFITN) decided to construct a checklist for neurointerventional cases based on a review of the literature and insights from an expert panel.
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