The relationship of the blood oxygen-level-dependent (BOLD) signal to its underlying neuronal activity is still poorly understood. Combined physiology and functional MRI experiments suggested that local field potential (LFP) is a better predictor of the BOLD signal than multiunit activity (MUA). To further explore this relationship, we simultaneously recorded BOLD and electrophysiological activity while inducing a dissociation of MUA from LFP activity with injections of the neuromodulator BP554 into the primary visual cortex of anesthetized monkeys. BP554 is a 5-HT1A agonist acting primarily on the membrane of efferent neurons by potassium-induced hyperpolarization. Its infusion in visual cortex reliably reduced MUA without affecting either LFP or BOLD activity. This finding suggests that the efferents of a neuronal network pose relatively little metabolic burden compared with the overall presynaptic and postsynaptic processing of incoming afferents. We discuss implications of this finding for the interpretation of BOLD activity.

2000-05-01·Molecular and Cellular Neuroscience2区 · 医学

Sequential Activation of the 5-HT1A Serotonin Receptor and TrkB Induces the Serotonergic Neuronal Phenotype

2区 · 医学

Article

作者: Dagmar Galter ; Klaus Unsicker

Serotonin (5-HT) is an important factor controlling survival, differentiation, and plasticity of neurons in serotonergic target regions of the brain and has been implicated in major psychiatric and autonomic disorders. Relatively little is known, however, of factors controlling differentiation and plasticity of developing and adult 5-HT neurons. We show now that 5-HT, the 5-HT1(A) receptor, brain-derived neurotrophic factor (BDNF), and its receptor, trkB, form an auto/paracrine loop for the regulation of the serotonergic phenotype. Serotonin applied to cultures from E14 rat raphe increased numbers of neurons expressing serotonergic markers in a dose-dependent manner. Agonists of the 5-HT1(A) receptor, BP-554 and 8-OH-DPAT, but not agonists of the 5-HT1(B) and 5-HT1(D) receptors, mimicked this effect, while the specific 5-HT1(A) antagonist, WAY-100635, inhibited it. Serotonin also increased BDNF mRNA and protein in embryonic raphe cultures. Induction of serotonergic markers by serotonin was suppressed by a trkB-IgG fusion protein but not by trkC-IgG. Taken together, our data indicate that serotonin acts on 5-HT1(A) autoreceptors, causing up-regulation of BDNF, which activates trkB to promote serotonergic phenotype-specific markers.

1991-08-01·European Journal of Pharmacology3区 · 医学

Gonadectomy changes the pituitaiy-adrenocortical response in mice to S-HT1A receptor agonists

3区 · 医学

Article

作者: Nakano Yoshihide ; Baba Akemichi ; Kanda Tomoyuki ; Matsuda Toshio ; Iwata Heitaroh

The effects of 5-HT1A receptor agonists such as 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), BP-554 and buspirone on the serum corticosterone level were significantly more pronounced in female than in male mice. A similar sex difference was observed for the effect of 8-OH-DPAT on the plasma ACTH level. Pretreatment with proadifen, an inhibitor of microsomal drug-metabolizing enzymes, did not affect the sex difference in the effect of 8-OH-DPAT. The corticosterone response to 8-OH-DPAT in female mice was attenuated by ovariectomy. The effect of 8-OH-DPAT in ovariectomized mice was enhanced by chronic estradiol and the enhancement was blocked by testosterone. In male mice the corticosterone response to 8-OH-DPAT increased at 5 weeks after castration but had not changed at 2 weeks. Chronic estradiol enhanced the corticosterone response to 8-OH-DPAT in castrated mice. There was no difference between sexes in [3H]8-OH-DPAT binding to membranes and in the contents of 5-HT and 5-hydroxyindoleacetic acid in the hypothalamus. Accumulation of 5-hydroxytryptophan after decarboxylase inhibition in the hypothalamus was however greater in female than in male mice.

100 项与 BP-554 相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
焦虑症	临床前	日本	Mitsubishi Chemical Corp.	-
焦虑症	临床前	日本	Mitsubishi Chemical Corp.	-
焦虑症	临床前	-	Mitsubishi Chemical Group Corp.	-
焦虑症	临床前	-	Mitsubishi Chemical Group Corp.	-