A Prospective Study Evaluating the Safety and Effectiveness of EVARREST® Fibrin Sealant Patch in Controlling Mild or Moderate Hepatic Parenchyma or Soft Tissue Bleeding During Open, Abdominal, Retroperitoneal, Pelvic and Thoracic (non-cardiac) Surgery in Pediatric Patients

开始日期2020-12-14

申办/合作机构-

NCT03255174 / Recruiting临床3期

A Prospective Study Evaluating the Safety and Effectiveness of EVARREST® Fibrin Sealant Patch in Controlling Mild or Moderate Hepatic Parenchyma or Soft Tissue Bleeding During Open Abdominal, Retroperitoneal, Pelvic and Thoracic (Non-cardiac) Surgery in Pediatric Patients

The objective of this study is to evaluate the safety and hemostatic effectiveness of EVARREST as an adjunct to controlling mild to moderate soft hepatic parenchyma or soft tissue bleeding during open hepatic, abdominal, pelvic, retroperitoneal, and thoracic (non-cardiac) surgery in pediatric population.

开始日期2018-03-20

申办/合作机构

Ethicon, Inc.

NCT02553122 / Withdrawn临床3期IIT

The Combined Efficacy of Evicel and Tranexamic Acid on Total Knee Arthroplasty During the Early Perioperative Period

Total knee arthroplasty is a surgical procedure that involves a significant amount of blood loss and it has always been the surgeons' goal to try to minimize blood loss. In the current study, we will investigate the effect of blood loss after total knee arthroplasty with the combination of Evicel, a fibrin sealant and Tranexamic Acid.

开始日期2015-10-01

申办/合作机构

Montefiore Medical Center

100 项与 Fibrin Sealant (Human) (Omrix) 相关的临床结果

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100 项与 Fibrin Sealant (Human) (Omrix) 相关的转化医学

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100 项与 Fibrin Sealant (Human) (Omrix) 相关的专利（医药）

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项与 Fibrin Sealant (Human) (Omrix) 相关的文献（医药）

2024-12-01·European Journal of Pediatric Surgery

A Study of Safety and Effectiveness of Evicel Fibrin Sealant as an Adjunctive Hemostat in Pediatric Surgery

Article

作者: Illie, Bogdan ; Barnett, Ellie ; Hall, Nigel J. ; Gabra, Hany ; Kocharian, Richard ; Sharif, Khalid ; Flageole, Helene ; Kenny, Simon

Introduction Data on the use of fibrin sealants to control intraoperative bleeding in children are scarce. Evicel Fibrin Sealant (Ethicon Inc., Raritan, New Jersey, United States) was found safe and effective in clinical trials of adults undergoing various surgery types. We evaluated the safety and efficacy of Evicel versus Surgicel Absorbable Hemostat (Ethicon Inc.) as adjunctive topical hemostats for mild/moderate raw-surface bleeding in pediatric surgery. Methods A phase III randomized clinical trial was designed as required by the European Medicines Agency's Evicel Pediatric Investigation Plan: 40 pediatric subjects undergoing abdominal, retroperitoneal, pelvic, or thoracic surgery were randomized to Evicel or Surgicel, to treat intraoperative mild-to-moderate bleeding. Descriptive analyses included time-to-hemostasis and rates of treatment success (4, 7, 10 minutes), intraoperative treatment failure, rebleeding, and thromboembolic events. Results Forty of 130 screened subjects aged 0.9 to 17 years were randomized 1:1 to Evicel or Surgicel. Surgeries were predominantly open abdominal procedures. The median bleeding area was 4.0 cm2 for Evicel and 1.0 cm2 for Surgicel. The median time-to-hemostasis was 4.0 minutes for both groups. The 4-, 7-, and 10-minute treatment success rates were 80.0% versus 65.0%, 100.0% versus 80.0%, and 95.0% versus 90.0%, whereas treatment failure rates were 5.0% versus 25.0%, for Evicel and Surgicel, respectively. No deaths or thrombotic events occurred. Re-bleeding occurred in 5.0% of Evicel and 10.0% of Surgicel subjects. Conclusions In accordance with adult clinical trials, this randomized study supports the safety and efficacy of Evicel for controlling mild-to-moderate surgical bleeding in a broad range of pediatric surgical procedures.

2024-11-01·Journal of Pediatric Surgery

A Phase 3, Randomized, Active-controlled, Single-blind Clinical Trial to Evaluate the Efficacy of Fibrin Sealant Grifols in Achieving Hemostasis in Pediatric Surgery

Article

作者: Jenovari, Zoltan ; James, Michael K. ; Mondou, Elsa ; Balanescu, Laura ; Bozzo, Jordi ; Kalinova, Krasimira ; Camprubí, Sandra ; Sharif, Khalid ; Camprubí, Sandra ; Ninov, Borislav ; Mikickovic, Maja ; Vajda, Péter ; Querolt, Montse ; Sretenović, Aleksandar ; Gajdobranski, Djordje ; Mondou, Elsa ; Slavkovic, Andjelka ; Simeonov, Simeon ; Hanna, Kim ; Hanna, Kim ; Irtan, Sabine ; Querolt, Montse ; Kamenov, Krasimir ; Wiener, Isodoro

BACKGROUNDIn this study, two fibrin sealant products, Fibrin Sealant Grifols (FS Grifols 80 mg/mL fibrinogen; 500 IU/mL thrombin) and Evicel (fibrinogen 55-85 mg/mL; thrombin 800-1200 IU/mL) were studied for efficacy in achieving hemostasis at a targeted bleeding site (TBS) on parenchymous or soft tissue in pediatric surgeries.METHODSThis phase 3, single-blind, active comparator, non-inferiority trial compared the number of patients achieving hemostasis at a TBS at four (T₄ - primary endpoint), seven (T₇) and 10 (T₁₀) minutes after application, Safety and tolerability were assessed by recording adverse events during and after procedures. Eligible patients were <18 years old undergoing elective, open, non-cardiac thoracic, abdominal or pelvic surgeries. Preterm (<37 weeks gestation) and newborn (0-27 days) infants were eligible.RESULTSAt T₄, 98.7% of FS Grifols group (n = 91) and 95.4% of the Evicel group (n = 87) achieved hemostasis. All patients with residual bleeding at T₄ were undergoing soft tissue surgery. All patients achieved hemostasis by T₇. At T₁₀, all patients achieved hemostasis except one (FS Grifols (no observation recorded)). There were no incidents of persistent bleeding. For FS Grifols, 26.5% of patients had treatment-emergent adverse events (TEAEs) and 18.4% for Evicel. One TEAE (moderate procedural pain - FS Grifols group) was considered possibly related to study treatment. Three patients died for reasons unrelated to the study medications.CONCLUSIONSFS Grifols was safe and effective at achieving hemostasis in pediatric patients having parenchymous or soft tissue surgeries. The efficacy of FS Grifols was non-inferior to Evicel.LEVEL OF EVIDENCEI.

2024-09-01·Child's Nervous System

Safety and effectiveness of Evicel® fibrin sealant as an adjunct to sutured dural repair in children undergoing cranial neurosurgery

Article

作者: Kocharian, Richard ; Sivakumar, Gnanamurthy ; Kandasamy, Jothy ; Barnett, Ellie ; Aquilina, Kristian ; Josan, Vivek ; Ilie, Bogdan ; Magdum, Shailendra ; Pettorini, Benedetta

AbstractPurposeCerebrospinal fluid (CSF) leakage is a challenging complication of intradural cranial surgery, and children are particularly at risk. The use of dural sealants confers protection in adults, but pediatric studies are scarce. We evaluated the safety and efficacy of Evicel® fibrin sealant as an adjunct to primary dural suturing in children undergoing cranial surgery.MethodsA multicenter trial prospectively enrolled pediatric subjects (< 18 years) undergoing cranial neurosurgery who, upon completion of primary sutured dural repair, experienced CSF leakage. As agreed by the EMA Evicel® Pediatric Investigation Plan, 40 subjects were intra-operatively randomized 2:1 to Evicel® or additional sutures (‘Sutures’). Data analysis was descriptive. The efficacy endpoint was treatment success rate, with success defined as intra-operative watertight closure after provocative Valsalva maneuver (primary endpoint). Safety endpoints were postoperative CSF leakage (incisional CSF leakage, pseudomeningocele or both) and surgical site complications (secondary endpoints).ResultsForty subjects (0.6–17 years) were randomized to Evicel® (N = 25) or Sutures (N = 15) (intention-to-treat). Intracranial tumor was the most common indication and procedures were mostly supratentorial craniotomies. Success rates were 92.0% for Evicel® and 33.3% for Sutures, with a 2.76 estimated ratio of success rates (Farrington-Manning 95% CI [1.53, 6.16]). Sensitivity analyses in per-protocol and safety sets showed similar results. Despite a higher rescue treatment rate, the frequencies of postoperative CSF leakage and wound complications were higher for Sutures than for Evicel®.ConclusionThis small-scale prospective study shows Evicel® treatment to be safe and effective as an adjunct to primary sutured dura mater closure in a pediatric population. Compared to additional sutures, Evicel® was associated with reduced postoperative CSF leakage and surgical site complications. (Trial registration: The trial was registered as NCT02309645 and EudraCT 2013-003558-26).

项与 Fibrin Sealant (Human) (Omrix) 相关的新闻（医药）

2022-06-11

·PRNewswire

At 8.6% CAGR, Global Tissue Sealants and Tissue Adhesive Market Size & Share to Surpass USD 2.9 Billion by 2028 | Industry Trends, Growth, Value, Opportunities, Statistics, Analysis & Forecast Report by ZMR

NEW YORK, June 11, 2022 /PRNewswire/ -- As per the Zion Market Research study, The global tissue sealants and tissue adhesive market was worth around USD 1.5 billion in 2021 and is estimated to grow to about USD 2.9 billion by 2028, with a compound annual growth rate (CAGR) of approximately 8.6 percent over the forecast period. The report analyzes the tissue sealants and tissue adhesive market's drivers, restraints/challenges, and the effect they have on the demands during the projection period. In addition, the report explores emerging opportunities in the tissue sealants and tissue adhesive market. Key Industry Insights &Findings of the Tissue Sealants and Tissue Adhesive Market Reports: As per the analysis shared by our research analyst, the Tissue Sealants and Tissue Adhesive Market is expected to grow annually at a CAGR of around 8.6% (2022-2028). Through the primary research, it was established that the Cognitive and Memory Enhancer Drugs Market was valued at approximately USD 1.5Billion in 2021 and is projected to reach roughly USD 2.9 Billion by 2028. Large population and technical advancements, North America accounted for the largest share of tissue sealants and tissue adhesive. State-of-the-art medical research facilities and rising investments in healthcare infrastructure in this region, and also heightened understanding among both physicians & patients relating to therapeutic approaches, enhanced life expectancy, and a rising population will push growing demands for tissue sealants and tissue adhesives in the Asia Pacific region. Zion Market Research published the latest report titled " Tissue Sealants And Tissue Adhesive Market By Product (Natural Or Biological Sealants & Adhesives And Synthetic & Semi-Synthetic Adhesives), By Application (General Surgery, Orthopedic Surgery, Gynecology Surgery, Cardiovascular Surgery, Cosmetic Surgery, Neurosurgery, And Other Applications), By End-User (Ambulatory Surgery Centers, Specialty Clinics, And Hospitals), And By Region – Global And Regional Industry Overview, Market Intelligence, Comprehensive Analysis, Historical Data, And Forecasts 2022 – 2028 "into their research database. Tissue Sealants and Tissue Adhesive Market: Overview Sealants are materials used by surgeon to heal tissue that has been injured by a surgery or injury. Skin, internal organs, and blood vessels are among the tissues that have been damaged. Sealants are used in combination with mechanical procedures like sutures and staples to assist minimize blood loss and avoiding leaks. Tissue adhesives are liquid monomers that, when exposed to a moist surface (skin), begin an exothermic reaction, transforming into a polymer that establishes a strong tissue connection. Get a Free Sample Report with All Related Graphs & Charts (with COVID 19 Impact Analysis): Our Free Sample Report Includes: 2022 Updated Report Introduction, Overview, and In-depth industry analysis COVID-19 Pandemic Outbreak Impact Analysis Included 166 + Pages Research Report (Inclusion of Updated Research) Provide Chapter-wise guidance on Request 2022 Updated Regional Analysis with Graphical Representation of Size, Share & Trends Includes an Updated List of tables & figures Updated Report Includes Top Market Players with their Business Strategy, Sales Volume, and Revenue Analysis Zion Market Research methodology Industry Dynamics: Tissue Sealants and Tissue Adhesive Market: Growth Drivers Increase in number of orthopedic and cardiovascular procedures to foster the market. Over the forecast period, rising cardiovascular and orthopedic surgeries are expected to drive revenue growth in the global tissue sealants and tissue adhesive market. The ease of availability of novel tissue adhesives and tissue sealants among end users, combined with rising disposable money, is a major driver in the global increase in such procedures. Adhesives are essential in general surgery. Natural and manufactured polymeric materials can be used to create three-dimensional networks that adhere to target tissues chemically and physically, acting as adhesives, sealants, or hemostats. Because adhesives and sealants are such an important aspect of general surgery, demand for them will rise as the number of procedures performed increases. As a result, market growth is likely to be boosted . Tissue Sealants and Tissue Adhesive Market: Restraints Less market penetration for tissue sealants and adhesives in developing countries hinders the growth. The market's growth is also likely to be hampered by the dearth of acceptance of tissue glue and bio-adhesive sealants in developing markets. This is due to a lack of knowledge about the advantages, cost-effectiveness, therapeutic application, and reliability of tissue adhesive and tissue sealants against alternative procedures or products, as well as tissue healing therapies. Directly Purchase a Copy of the Report @ Global Tissue Sealants and Tissue Adhesive Market: Opportunities Technological advancement for product launches creates numerous opportunities for market growth. Companies have been working on the development of novel tissue glue and bio-adhesive sealants to reach a variety of consumers, including toddlers, and young and elderly patients, during the last few years. Tissue sealants are currently used to protect sensitive, fragile, skin from damage, and to prevent cross-contamination & infection transmission. For innovative product launches, major companies are investing heavily in R&D activities. All such factors are likely to generate numerous opportunities for the global tissue sealants and tissue adhesive market growth during the forecast period. Global Tissue Sealants and Tissue Adhesive Market: Challenges Limitations in the development of tissue adhesive to act as a major challenge for the market growth. Despite the fact that many tissue adhesives form strong connections with tissue, they are frequently not designed for specific tissue applications. Tissue adhesives, in particular, do not biodegrade at a rate consistent with tissue repair, cause an unwanted inflammatory response upon adhesion or disintegration, fail to cohere in high-load-bearing applications, or do not match the characteristics of the underlying tissue. In the early stages of development, rigorous differentiation of target applications and greater in-depth investigation of tissue-surface features and tissue-environmental parameters are necessary. Despite the fact that the surface of the tissue and the surrounding environment change amongst tissues, the most typical technique is to utilize one type of adhesive for all conceivable tissues. This "one-size-fits-all" approach frequently results in tissue adhesive misuse, leading to inferior performance and dampening enthusiasm for potentially promising new materials. This could also lead to an incorrect cost-effectiveness analysis for specified unmet clinical requirements in the early stages of development, culminating in an exaggeration of cost in later stages of development and obstructing clinical translation. A failure to understand the physiological effects of adhesive materials after implantation is another factor for the research-to-product mismatch. All such limitations may pose challenges to market growth . Global Tissue Sealants and Tissue Adhesive Market: Segmentation The global tissue sealants and tissue adhesive market is categorized based on product, application, end-user, and region. Based on the product, the market is divided into semi-synthetic & synthetic adhesives and biological or natural sealants. The application segment consists of neurosurgery, cosmetic surgery, cardiovascular surgery, gynecology surgery, orthopedic surgery, general surgery, and other applications. The end-user segment is bifurcated into ambulatory surgery centers, specialty clinics, and hospitals. Get More Insight before [email protected]: List of Key Players inTissue Sealants and Tissue Adhesive Market: Integra LifeSciences C.R Bard Smith & Nephew Exapharma Johnson & Johnson Baxter International Inc. Tissuemed Ltd. Chemence Medical Inc. Cohera Medical Inc. Luna Innovations Incorporated Key questions answered in this report: What are the growth rate forecast and market size for Tissue Sealants and Tissue Adhesive Market? What are the key driving factors propelling the Tissue Sealants and Tissue Adhesive Market forward? What are the most important companies in the Tissue Sealants and Tissue Adhesive Market Industry? What segments does the Tissue Sealants and Tissue Adhesive Market cover? How can I receive a free copy of the Tissue Sealants and Tissue Adhesive Market sample report and company profiles? Report Scope: Free Brochure: Recent Developments: In January 2020, Polyganics, a medical technology business that develops, manufactures, and sells bioresorbable medical devices, revealed that LIQOSEAL®, its effortless and unique dural sealant patch, has received CE certification and will be available in Europe immediately. In December 2019, Johnson & Johnson Medical Devices Companies announced that Ethicon has released VISTASEAL Fibrin Sealant (Human) to assist surgeons minimize bleeding during surgery. VISTASEAL Fibrin Sealant (Human) is made up of fibrinogen and thrombin, which are both clotting proteins present in human plasma. It creates a fast, adherent, and permanent clot after placed on the bleeding site and has been shown to maintain hemostasis (blood stoppage) in high-risk patients. Regional Dominance: North America is the leader in the global market. Among the regions, North America is estimated to lead the global tissue sealants and tissue adhesive market during the forecast period. Because of its large population and technical advancements, North America accounted for the largest share of tissue sealants and tissue adhesive. However, the market for tissue sealants and tissue adhesives is expected to expand significantly in Asia Pacific countries. Factors such as state-of-the-art medical research facilities and rising investments in healthcare infrastructure in this region, and also heightened understanding among both physicians & patients relating therapeutic approaches, enhanced life expectancy, and a rising population will push growing demands for tissue sealants and tissue adhesives in Asia Pacific region. Global Tissue Sealants and Tissue Adhesive Market is segmented as follows: Tissue Sealants and Tissue Adhesive Market:ByProduct Outlook(2022-2028) Natural or Biological Sealants and Adhesives Synthetic and Semi-Synthetic Adhesives Tissue Sealants and Tissue Adhesive Market: By ApplicationOutlook (2022-2028) General Surgery Orthopedic Surgery Gynecology Surgery Cardiovascular Surgery Cosmetic Surgery Neurosurgery Other Applications Tissue Sealants and Tissue Adhesive Market: By End-user Outlook (2022-2028) Hospitals Specialty Clinics Ambulatory Surgery Centers Tissue Sealants and Tissue Adhesive Market:By Region Outlook(2022-2028) North America The U.S. Canada Europe France The UK Spain Germany Italy Rest of Europe Asia Pacific China Japan India South Korea Southeast Asia Rest of Asia Pacific Latin America Brazil Mexico Rest of Latin America Middle East & Africa GCC South Africa Rest of Middle East & Africa Browse Other Related Research Reports from Zion Market Research Orthopedic Navigation Systems Market - Global Industry Analysis : The global Orthopedic Navigation Systems market accrued earnings worth approximately 2.1(USD Billion) in 2020 and is predicted to gain revenue of about 7.3 (USD Billion) by 2028, is set to record a CAGR of nearly 14.7% over the period from 2021 to 2028. Intravenous Infusion Pumps Market - Global Industry Analysis : The global Intravenous Infusion Pumps market accrued earnings worth approximately 4.7 (USD Billion) in 2020 and is predicted to gain revenue of about 8.9 (USD Billion) by 2028, is set to record a CAGR of nearly 8.1% over the period from 2021 to 2028. Disposable Hospital Gowns Market - Global Industry Analysis : The global Disposable Hospital Gowns market accrued earnings worth approximately 2.02 (USD Billion) in 2020 and is predicted to gain revenue of about 5.72 (USD Billion) by 2028, is set to record a CAGR of nearly 13.8% over the period from 2021 to 2028. Browse through Zion Market Research's coverage of the Global Medical Device Industry Follow Us on: LinkedIn | Twitter | Facebook About Us Zion Market Research is an obligated company. We create futuristic, cutting-edge, informative reports ranging from industry reports, and company reports to country report. We provide our clients not only with market statistics unveiled by avowed private publishers and public organizations but also with vogue and newest industry reports along with pre-eminent and niche company profiles. Our database of market research reports comprises a wide variety of reports from cardinal industries. Our database is been updated constantly in order to fulfill our clients with prompt and direct online access to our database. Keeping in mind the client's needs, we have included expert insights on global industries, products, and market trends in this database. Last but not the least, we make it our duty to ensure the success of clients connected to us—after all—if you do well, a little of the light shines on us . Contact Us: Zion Market Research 244 Fifth Avenue, Suite N202 New York, 10001, United States Tel: +49-322 210 92714 USA/Canada Toll Free No.1-855-465-4651 Email: [email protected] Website: Blog - Logo: SOURCE Zion Market Research

2022-06-09

·PRNewswire

Global Surgical Sealants and Adhesives Market (2022 to 2030) - Size, Share & Trends Analysis Report

DUBLIN, June 9, 2022 /PRNewswire/ -- The "Surgical Sealants and Adhesives Market Size, Share & Trends Analysis Report by Type (Natural or Biological, Synthetic & Semi-synthetic), by Application (General Surgery, Cardiovascular), by Region, and Segment Forecasts, 2022-2030" report has been added to ResearchAndMarkets.com's offering. The global surgical sealants and adhesives market size is expected to reach USD 5.4 billion by 2030. It is expected to expand at a CAGR of 11.4% from 2022 to 2030. Proper closure of injured tissues post-operation is a major step to restore tissue's structure and function. Postoperative leakages occur in 3% to 15% of cases and are considered serious complications. They are responsible for one-third of postoperative deaths in patients. Surgical sealants and adhesives are designed to improve patient outcomes by reducing the prospect of postsurgical complications, such as leakages, thus resulting in improved patient outcomes through the prevention of leakage and a decrease in length of stay and mortality rates. The rapid advancements in sealants and adhesives are major impact rendering drivers, and their usage in modern surgery to reduce anastomotic leakage has risen significantly. Surgical adhesive is expected to replace traditional surgical sealing agents such as sutures, wires, and staples. These are time taking, can result in further tissue trauma, and are hard to use in some surgical locations. Surgical sealants overcome these issues and create immediate and proper sealing, compared to sutures and staples. The factors contributing to the growth of the market are the rising demand for surgical services worldwide and increasing concerns to reduce postoperative wound infections. Surgical procedures are increasing worldwide, with the WHO estimations projecting surgeries to account for approximately 235 million per year globally. Surgical Sealants and Adhesives Market Report Highlights North America held the largest revenue share in 2021 owing to the growing demand for high-quality healthcare in the region. Asia Pacific is expected to observe lucrative growth over the forecast period due to the transformation of healthcare delivery systems into advanced value-based healthcare practices to establish a sustainable health system. In the natural and biological adhesives and sealants type segment, the fibrin sealants segment accounted for the largest revenue share in 2021. In the synthetic and semi-synthetic adhesives and sealants type segment, the cyanoacrylates segment is expected to register the fastest growth rate in the forecast period owing to its fast-drying properties, strong mechanical strength, and ease of adhesion. Market participants combine a blend of both large public companies and more specialized small companies. These companies focus on only one segment or product. An example of such companies is Cohera Medical, Inc. Key Topics Covered: Chapter 1. Methodology and Scope Chapter 2. Executive Summary Chapter 3. Surgical Sealants and Adhesives Market Variables, Trends & Scope 3.1. Market Segmentation & Scopes 3.2. Surgical Sealants and Adhesives: Market Dynamics 3.2.1. Market driver analysis 3.2.2. Market restraint analysis 3.3. Key Opportunities Prioritized 3.4. Surgical Sealants and Adhesives-SWOT Analysis, by Factor (Political & legal, economic and technological) 3.5. Industry Analysis-Porter's 3.6. Surgical Sealants and Adhesives Market: Market Position Analysis, 2015 Chapter 4. Surgical Sealants and Adhesives: Type Estimates & Trend Analysis 4.1. Surgical Sealants and Adhesives Market: Type Movement Analysis 4.1.1. Natural or biological adhesives and sealants 4.1.1.1. Natural or biological adhesives and sealants market, 2018-2030 (USD Million) 4.1.1.1.1. Fibrin Sealants 4.1.1.1.1.1. Fibrin sealants market, 2018-2030 (USD Million) 4.1.1.1.2. Collagen Based Adhesives 4.1.1.1.2.1. Collagen based adhesives market, 2018-2030 (USD Million) 4.1.1.1.3. Gelatin Based Adhesives 4.1.1.1.3.1. Gelatin based adhesives market, 2018-2030 (USD Million) 4.1.2. Synthetic and Semi-synthetic Adhesives and Sealants 4.1.2.1. Synthetic and semi-synthetic adhesives and sealants market, 2018-2030 (USD Million) 4.1.2.1.1. Cyanoacrylates 4.1.2.1.1.1. Cyanoacrylates market, 2018-2030 (USD Million) 4.1.2.1.2. Polymeric Hydrogels 4.1.2.1.2.1. Polymeric hydrogels market, 2018-2030 (USD Million) 4.1.2.1.3. Urethane Based Adhesives 4.1.2.1.3.1. Urethane based adhesives market, 2018-2030 (USD Million) Chapter 5. Surgical Sealants and Adhesives: Application Estimates & Trend Analysis 5.1. Surgical Sealants and Adhesives Market: Application Movement Analysis 5.1.1. Central nervous system 5.1.1.1. Central nervous system market, 2018-2030 (USD Million) 5.1.2. Cardiovascular 5.1.2.1. Cardiovascular market, 2018-2030 (USD Million) 5.1.3. General surgery 5.1.3.1. General surgery market, 2018-2030 (USD Million) 5.1.4. Orthopedic 5.1.4.1. Orthopedic market, 2018-2030 (USD Million) 5.1.5. Pulmonary 5.1.5.1. Pulmonary market, 2018-2030 (USD Million) 5.1.6. Urology 5.1.6.1. Urology market, 2018-2030 (USD Million) 5.1.7. Ophthalmology 5.1.7.1. Ophthalmology market, 2018-2030 (USD Million) 5.1.8. Others 5.1.8.1. Others market, 2018-2030 (USD Million) Chapter 6. Surgical Sealants and Adhesives: Regional Estimates & Trend Analysis, by Type and Application Chapter 7. Competitive Landscape 7.1. Company Profiles 7.1.1. Baxter International, Inc. 7.1.1.1. Company overview 7.1.1.2. Financial performance 7.1.1.3. Product benchmarking 7.1.1.4. Strategic initiatives 7.1.2. CryoLife, Inc. 7.1.2.1. Company overview 7.1.2.2. Financial performance 7.1.2.3. Product benchmarking 7.1.2.4. Strategic initiatives 7.1.3. C.R. Bard, Inc. 7.1.3.1. Company overview 7.1.3.2. Financial performance 7.1.3.3. Product benchmarking 7.1.3.4. Strategic initiatives 7.1.4. Medtronic PLC 7.1.4.1. Company overview 7.1.4.2. Financial performance 7.1.4.3. Product benchmarking 7.1.4.4. Strategic initiatives 7.1.5. B. Braun Melsungen AG 7.1.5.1. Company overview 7.1.5.2. Financial performance 7.1.5.3. Product benchmarking 7.1.5.4. Strategic initiatives 7.1.6. Cohera Medical, Inc. 7.1.6.1. Company overview 7.1.6.2. Financial performance 7.1.6.3. Product benchmarking 7.1.6.4. Strategic initiatives 7.1.7. Ethicon, Inc. 7.1.7.1. Company overview 7.1.7.2. Financial performance 7.1.7.3. Product benchmarking 7.1.7.4. Strategic initiatives 7.1.8. Mallinckrodt PLC 7.1.8.1. Company overview 7.1.8.2. Financial performance 7.1.8.3. Product benchmarking 7.1.8.4. Strategic initiatives 7.1.9. Cardinal Health 7.1.9.1. Company overview 7.1.9.2. Financial performance 7.1.9.3. Product benchmarking 7.1.9.4. Strategic initiatives 7.1.10. Integra LifeSciences Holdings Corporation 7.1.10.1. Company overview 7.1.10.2. Financial performance 7.1.10.3. Product benchmarking 7.1.10.4. Strategic initiatives For more information about this report visit ? Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1904 Fax (outside U.S.): +353-1-481-1716 SOURCE Research and Markets

100 项与 Fibrin Sealant (Human) (Omrix) 相关的药物交易

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适应症	国家/地区	公司	日期
出血	美国	Ethicon, Inc.	2012-12-05

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适应症	最高研发状态	国家/地区	公司	日期
外周血管疾病	临床前	美国	Ethicon, Inc.	2005-06-01
外周血管疾病	临床前	英国	Omrix Biopharmaceuticals Ltd.	2005-06-01
外周血管疾病	临床前	美国	Omrix Biopharmaceuticals Ltd.	2005-06-01
外周血管疾病	临床前	英国	Ethicon, Inc.	2005-06-01
出血	药物发现	美国	Omrix Biopharmaceuticals Ltd.	2003-03-21

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


EUCTR2013-003558-26-GB \| NCT02309645 (Pubmed) 人工标引	临床3期	脑脊液漏	40	Evicel® fibrin sealant	(襯繭簾糧繭壓糧製糧製) = 齋淵觸鬱鑰糧鏇顧範蓋蓋觸蓋膚齋膚積願鹽夢 (窪網網醖鹹淵選齋夢構 )	积极	2024-05-10
				Sutures	(襯繭簾糧繭壓糧製糧製) = 顧簾選觸鑰糧觸鬱窪艱蓋觸蓋膚齋膚積願鹽夢 (窪網網醖鹹淵選齋夢構 )
NCT02227992 (CTgov)	临床3期	出血	40	Fibrinogen+EVARREST+Thrombin (EVARREST Sealant Matrix)	構窪壓網製艱範繭遞鬱(獵鹽廠齋壓艱築築壓積) = 襯繭範鏇齋餘構構簾遞艱願衊範選鑰襯鹹觸範 (鏇衊願淵觸鏇鬱壓鬱廠, 範選網製築鹽積鏇廠壓 ~ 膚廠艱窪範網鹽醖範窪) 更多	-	2023-09-08
				oxidized regenerated cellulose (SURGICEL Absorbable Hemostat (Control))	構窪壓網製艱範繭遞鬱(獵鹽廠齋壓艱築築壓積) = 製積齋醖簾齋鬱鹹鏇糧艱願衊範選鑰襯鹹觸範 (鏇衊願淵觸鏇鬱壓鬱廠, 獵衊構襯網蓋簾壓鹽構 ~ 鏇築鹽膚遞鑰製齋繭鹽) 更多
NCT02227706 (CTgov)	临床3期	出血 \| 口腔出血	40	EVICEL (EVICEL®)	壓壓願憲繭積窪夢廠簾(窪夢鬱願膚遞構網鏇壓) = 壓艱衊憲醖淵積獵製膚餘製膚製鹽蓋選願築繭 (網鹹襯網鏇夢觸窪夢鏇, 鹹齋鬱鑰繭觸衊壓獵顧 ~ 網築築膚鹹繭蓋範蓋獵) 更多	-	2020-08-31
				SURGICEL (SURGICEL®)	壓壓願憲繭積窪夢廠簾(窪夢鬱願膚遞構網鏇壓) = 簾廠構淵衊鹹鏇膚獵鹽餘製膚製鹽蓋選願築繭 (網鹹襯網鏇夢觸窪夢鏇, 壓鬱願獵艱窪顧簾鏇襯 ~ 襯廠壓襯鏇鏇淵蓋鏇壓) 更多
NCT01226914 (CTgov)	N/A	术后并发症 \| 甲状腺肿 \| 甲状腺癌	55	EVICEL (EVICEL)	齋鑰築鏇艱齋廠糧製鏇(積願壓製憲遞願製遞糧) = 獵製淵淵鹽簾鏇鹽蓋鹹獵餘簾網襯淵襯鹹壓觸 (構顧壓鑰糧醖膚壓積願, 淵蓋餘繭願顧鬱願構淵 ~ 窪齋鑰膚繭簾願獵鏇蓋) 更多	-	2019-02-05
				EVICEL (Placebo)	齋鑰築鏇艱齋廠糧製鏇(積願壓製憲遞願製遞糧) = 製窪鹽鑰鹽鬱觸鹹齋餘獵餘簾網襯淵襯鹹壓觸 (構顧壓鑰糧醖膚壓積願, 鏇獵餘醖網製衊鏇遞蓋 ~ 鏇構壓範餘淵鏇蓋鬱選) 更多
NCT02457546 (CTgov)	临床3期	脑脊液漏	234	EVICEL (Evicel)	鑰衊齋蓋鹹壓廠獵艱繭(鬱範製衊窪觸醖齋襯窪) = 鑰顧鬱觸鬱膚繭淵顧獵廠觸製鑰網範鬱製淵糧 (遞網顧衊鬱繭鬱範繭遞, 壓觸衊艱鹹廠壓壓醖網 ~ 壓觸獵選構顧築顧夢鑰) 更多	-	2018-12-04
				rilysine (DuraSeal)	鑰衊齋蓋鹹壓廠獵艱繭(鬱範製衊窪觸醖齋襯窪) = 艱網鬱廠壓夢築觸窪醖廠觸製鑰網範鬱製淵糧 (遞網顧衊鬱繭鬱範繭遞, 繭窪醖觸憲鹹齋糧廠齋 ~ 壓構觸製鹽齋範壓遞鏇) 更多
NCT02034799 (CTgov)	临床4期	脑膜瘤	256	Standard of Care (SoC) (Standard of Care (SoC))	鑰簾醖繭鏇壓鬱醖顧衊(鹽構範簾遞窪憲鹹簾積) = 餘壓窪醖鑰繭鑰顧獵淵糧鹹鑰製願艱鑰憲簾網 (積窪鹽獵網繭憲醖簾獵, 願糧餘繭衊醖鹹鏇壓膚 ~ 襯簾繭夢獵鹹蓋選選齋) 更多	-	2018-02-26
				Bioseal Fibrin Sealant (Bioseal Fibrin Sealant)	鑰簾醖繭鏇壓鬱醖顧衊(鹽構範簾遞窪憲鹹簾積) = 壓繭齋範築顧鏇襯範顧糧鹹鑰製願艱鑰憲簾網 (積窪鹽獵網繭憲醖簾獵, 齋鬱醖艱鏇憲憲膚鬱夢 ~ 鬱簾築築鹽憲糧遞積鏇) 更多
NCT02040428 (CTgov)	临床3期	心血管疾病	156	Fibrin Sealant Patch (EVARREST Fibrin Sealant Patch)	獵範顧齋餘鑰繭窪襯遞(選鹽艱鑰鏇製觸蓋築衊) = 齋鏇壓膚醖獵遞觸築艱衊構遞積齋衊顧鏇醖簾 (鏇構觸齋製簾窪構憲網, 憲襯積艱廠鹽艱簾鹽襯 ~ 鬱積襯範遞鑰觸積鏇鹹) 更多	-	2017-08-15
				TachoSil+thrombin (TachoSil)	獵範顧齋餘鑰繭窪襯遞(選鹽艱鑰鏇製觸蓋築衊) = 蓋選襯壓襯蓋網糧鑰鹽衊構遞積齋衊顧鏇醖簾 (鏇構觸齋製簾窪構憲網, 顧襯襯鏇顧鬱積襯廠鹽 ~ 鑰觸選願襯築壓餘顧構) 更多
NCT02094885 (CTgov)	临床4期	出血	252	Bioseal Fibrin Sealant (Bioseal Fibrin Sealant)	淵繭蓋選齋醖顧淵糧積(鏇壓衊壓鏇選構糧選鑰) = 獵蓋鹽夢廠網醖糧蓋醖鑰鑰襯積築範鏇齋壓鹹 (顧製鬱艱襯窪觸範構鬱, 窪餘鏇願範繭鑰醖廠膚 ~ 襯選願築簾壓繭選膚築) 更多	-	2016-09-12
				Manual Compression (Manual Compression)	淵繭蓋選齋醖顧淵糧積(鏇壓衊壓鏇選構糧選鑰) = 壓網繭積鹽齋範膚憲顧鑰鑰襯積築範鏇齋壓鹹 (顧製鬱艱襯窪觸範構鬱, 願膚築範蓋齋鬱製網鏇 ~ 艱鑰糧鑰淵鹹膚選鹹襯) 更多
NCT01993888 (CTgov)	临床3期	脑出血 \| 出血	102	Standard of Care (SoC)	鹹製壓範簾膚獵構築鑰(遞鹹餘淵餘膚艱鹽鬱淵) = 鑰糧範蓋壓觸獵築顧繭範選製廠膚鬱鏇窪構夢 (鑰顧鹹遞觸餘築憲餘膚, 構鏇選鹽獵顧窪觸襯顧 ~ 襯壓鹹積構鬱蓋製鏇夢) 更多	-	2016-07-11
ARVO2013	N/A	翼状胬肉	96	Evicel	(簾觸簾艱壓顧蓋網膚膚) = 窪餘構繭廠餘製糧鑰壓築壓壓糧網艱顧憲願繭 (齋鬱築蓋選齋鑰衊艱廠 ) 更多	积极	2013-06-01
				Tisseel	(簾觸簾艱壓顧蓋網膚膚) = 簾遞廠衊餘醖廠鬱網繭築壓壓糧網艱顧憲願繭 (齋鬱築蓋選齋鑰衊艱廠 ) 更多