更新于：2024-11-21

Diphtheria,Tetanus and Acellular Pertussis Combined Vaccine, Adsorbed(Changchun Longevity Biological Technology Limited Liability Company)

无细胞百白破联合(长春长生生物科技有限责任公司)

更新于：2024-11-21

概要

基本信息

药物类型

联合疫苗、预防性疫苗、类毒素疫苗

别名

Diphtheria,Tetanus and Acellular Pertussis Combined Vaccine,Adsorbed、吸附无细胞百白破联合疫苗（长春长生）

靶点-

作用机制

免疫刺激剂

治疗领域

感染呼吸系统疾病其他疾病

在研适应症-

非在研适应症

白喉破伤风百日咳

原研机构

长春长生生物生命科学研究所有限公司

在研机构-

非在研机构

长春长生生物生命科学研究所有限公司

最高研发阶段撤市

首次获批日期

中国 (2008-10-20),

白喉破伤风百日咳

最高研发阶段(中国)撤市

特殊审评-

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关联

100 项与无细胞百白破联合(长春长生生物科技有限责任公司) 相关的临床结果

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100 项与无细胞百白破联合(长春长生生物科技有限责任公司) 相关的转化医学

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100 项与无细胞百白破联合(长春长生生物科技有限责任公司) 相关的专利（医药）

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19

项与无细胞百白破联合(长春长生生物科技有限责任公司) 相关的文献（医药）

2023-04-01·Infectious diseases and therapy

Knowledge, Attitudes, and Practices Concerning Maternal Immunization Among Pregnant/Postpartum Women and Health Care Professionals in Peru.

Article

作者: Juliao, Patricia ; Guzman-Holst, Adriana ; Velez, Claudia ; Ochoa, Theresa J ; Petrozzi, Veronica ; Gupta, Vinay

INTRODUCTIONFor pregnant women, vaccination with inactivated influenza vaccine (IIV) and tetanus, diphtheria, acellular pertussis vaccine (Tdap) is recommended. In Peru, uptake is nonetheless low. A study was conducted to identify factors affecting maternal vaccination coverage. The study's primary objectives were to describe the knowledge, attitudes, and practices regarding maternal immunization among pregnant/postpartum women and health care professionals (HCPs). The secondary objective was to determine the vaccination coverage and the impact of Ministry of Health (MOH) recommendations.METHODSAn observational multicenter, cross-sectional survey study was conducted from February 1, 2021 to June 30, 2021 in five cities in Peru. Two surveys were conducted to assess knowledge, attitudes, and practices concerning maternal immunization: one among pregnant/postpartum women and one among HCPs.RESULTSParticipants were 668 pregnant/postpartum women with a mean age of 29.6 years and 219 HCPs-mostly midwives (46.6%) and obstetricians/gynecologists (44.7%). Of the pregnant/postpartum women, 66.9% knew that, in general, vaccinations are given for prevention, and 98.5% believed vaccines are important. Nonetheless, 69.6% of pregnant/postpartum women had poor or moderate knowledge of maternal vaccination. Disease knowledge of influenza (89.1%) and tetanus (87.0%) was high, while knowledge of pertussis (37.7%) was low. Women agreed/strongly agreed that they would get vaccinated with Tdap if a doctor (96.3%), midwife (88.9%), or nurse (72.0%) recommended it. Of the HCPs, 81.3% routinely recommended Tdap vaccination for pregnant women.CONCLUSIONSTo enhance vaccine acceptance in pregnant women in Peru, we must improve knowledge of the diseases, MOH recommendations, and benefits of the offered vaccinations. HCPs could provide this vaccination knowledge and information along with their vaccination recommendation as the pregnant/postpartum women indicated they would take the vaccines if recommended by their HCPs. Our findings are important for the successful implementation of maternal immunization programs in Peru.

2022-12-06·Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Analysis for dropout of DTaP routine immunization in China in 2019].

Article

作者: Ye, J K ; Song, Y F ; Cao, L ; Yu, W Z ; Yin, Z D

目的： 分析2019年中国吸附无细胞百白破疫苗（DTaP）常规免疫脱漏情况。 方法： 利用中国免疫规划信息管理系统收集的2019年全国分县区的DTaP免疫接种数据，计算不同省份DTaP的累计接种率和脱漏率；依据各省份县区DTaP脱漏率的P₂₅、P₅₀、P₇₅，将各省份所辖县区分为4组（Q₁~Q₄），分别计算4组县区的DTaP平均脱漏率和绝对差值（Q₄组与Q₁组县区DTaP平均脱漏率之差）；采用Spearman秩相关分析绝对差值与省级DTaP脱漏率、第1剂次DTaP（DTaP₁）和第3剂次DTaP（DTaP₃）接种率的关系。 结果： 2019年中国各省份DTaP₁接种率在92.98%~99.94%之间，M为99.55%；各省份省级DTaP脱漏率在0.36%~28.66%之间，M为3.54%。省级DTaP脱漏率超过10%的省份有甘肃和贵州，分别为28.66%、17.19%；各省份绝对差值在4.02%~39.22%之间，M为10.16%；绝对差值较大的省份有甘肃、青海、辽宁和贵州，分别为39.22%、34.48%、23.31%和21.33%。Spearman秩相关分析结果显示，绝对差值与省级DTaP脱漏率呈正相关，r_s为0.492（P=0.004），与DTaP₁、DTaP₃接种率均呈负相关，r_s分别为-0.542（P=0.001）和-0.562（P=0.001）。 结论： 2019年中国部分省份县区间的DTaP脱漏率存在差异，西部省份县区差异性相对较高。.

2020-10-01·Vaccine3区 · 医学

Elucidating the difference in the kinetics of antibody titres of infants in Belgium and Vietnam

3区 · 医学

Article

作者: Hoang, Ha Thi Thu ; Leuridan, Elke ; Maertens, Kirsten ; Van Damme, Pierre ; Hens, Niel ; Tran, Thao Mai Phuong

Serological results obtained in a single laboratory from twin-studies on maternal immunisation, in Vietnam and Belgium offer the opportunity to compare antibody kinetics in infants before and after infant vaccination in the presence of vaccine-induced maternal antibodies. Nonlinear mixed-effects models (NLMMs) making use of a hypothesised dynamic evolution that captures the change in antibody titres over time, were employed to model anti-PT and anti-Prn antibody dynamics. Our proposed modelling approach provided useful insight into understanding the differences in the infants' antibody kinetics in both countries since NLMMs offer the possibility of pooling all data in one analysis and incorporate relevant covariates of interest. In both controlled cohort studies, pregnant women were vaccinated with a tetanus, diphtheria, acellular pertussis (Tdap) vaccine (Boostrix®, Belgium; Adacel®, Vietnam), and children were followed before and after primary vaccination, and before and after booster vaccination (Infanrix hexa®). From our models, both anti-PRN and anti-PT antibody titres at birth of Vietnamese infants were significantly lower than those of Belgian infants born to vaccinated women groups. Even though the antibody titres in the cord at birth of Belgian infants were also higher than those of Vietnamese infants born to the control women groups, the difference was not significant. The significant difference between infants born to vaccinated women in the two countries was likely due to the use of different vaccine brands in pregnant women and the different vaccination histories of women in these two countries. Our analyses also suggested that the blunting effect was present during the primary immunisation but went away afterward for anti-PT data. In contrast, for anti-PRN antibodies, the blunting effect persisted after the primary vaccination and possibly went away after the booster dose. Countries should be aware of the regional situation in view of recommending maternal immunization.

100 项与无细胞百白破联合(长春长生生物科技有限责任公司) 相关的药物交易

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