双孢蘑菇提取物(Agaricus bisporus extract) - 在研适应症：前列腺腺癌，遗传性前列腺癌7型，复发性前列腺癌_专利_临床

概要

基本信息

药物类型

中药

别名

white button mushroom extract

靶点-

作用方式-

作用机制-

治疗领域

肿瘤口颌疾病泌尿生殖系统疾病+ [1]

在研适应症

前列腺腺癌遗传性前列腺癌7型复发性前列腺癌+ [1]

非在研适应症

乳腺癌非转移性前列腺癌

原研机构

National Cancer Institute

在研机构

City of Hope National Medical Center

National Cancer Institute

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

4

项与双孢蘑菇提取物相关的临床试验

NCT04913064

/ RecruitingN/AIIT

White Button Mushroom and Biomarkers of Immune Cell and Inflammatory Responses in Obese Postmenopausal Women at High Risk of Breast Cancer

This clinical trial studies the effects of dietary white button mushroom on inflammation (the body's process of fighting against harmful things) and immune cells (white blood cells) in postmenopausal women with both high body mass index or BMI (percentage of body fat) and high risk of breast cancer. The body is in a constant state of alert when inflammation lingers at a low level and becomes chronic, as with having button mushroom is a dietary supplement that may improving responses of immune cells (white blood cells) and decreasing chronic inflammation.
Information gathered from this study may help researchers determine whether white button mushroom have any effects on body fat and breast cancer risk.

开始日期2021-07-27

申办/合作机构

City of Hope National Medical Center

[+1]

NCT04519879

/ Recruiting临床2期IIT

A Randomized Phase 2 Trial of White Button Mushroom Supplement in Patients With Biochemically Recurrent Prostate Cancer Following Local Therapy and in Therapy Na?ve Patients With Favorable Risk Prostate Cancer Undergoing Active Surveillance

This phase II trial studies how well white button mushroom supplement works in reducing prostate-specific antigen (PSA) levels in patients with prostate cancer that has come back (recurrent) or has favorable risk and has not undergone any therapy (therapy naive). PSA is a blood marker of prostate growth. White button mushroom supplement may affect PSA level, various parameters of immune system and levels of hormones that may have a role in prostate cancer growth.

开始日期2021-05-10

申办/合作机构

City of Hope National Medical Center

[+1]

NCT00779168

/ Completed临床1期IIT

A Phase Ib Trial of Mushroom Powder in Biochemically Recurrent Prostate Cancer

RATIONALE: White button mushroom extract may stop or delay the development of recurrent prostate cancer.
PURPOSE: This phase I trial is studying the side effects and best dose of white button mushroom extract in treating patients with recurrent prostate cancer after local therapy.

开始日期2009-01-29

申办/合作机构

City of Hope National Medical Center

[+1]

100 项与双孢蘑菇提取物相关的临床结果

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100 项与双孢蘑菇提取物相关的转化医学

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100 项与双孢蘑菇提取物相关的专利（医药）

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2

项与双孢蘑菇提取物相关的文献（医药）

2018-01-01·International Journal of Medicinal Mushrooms4区 · 生物学

Powder of the White Bottom Mushroom, Agaricus bisporus (Agaricomycetes), Improved Immunomodulatory and Health-Promoting Effects of Lactobacillus casei in Zebrafish (Danio rerio)

4区 · 生物学

Article

作者: Khalili, Mohsen ; Hoseinifar, Seyed Hossein ; Dadar, Maryam ; Safari, Roghieh

This study was conducted to investigate the effects of Lactobacillus casei and Agaricus bisporus administration, alone or in combination, on skin mucus immune parameters and the expression of selected genes related to growth, appetite, mucosal immunity, and antioxidant enzymes in zebrafish (Danio rerio). Zebrafish (n = 600) were randomly stocked in 12 aquariums and assigned to 1 of 4 treatments, which were repeated in triplicate. During a 60-day feeding trial, fish were fed experimental diets: (1) basal diet (control group); (2) basal diet + L. casei (107 colony-forming units/g; Pro group); (3) basal diet + 1% A. bisporus [mushroom powder [MP] group); and (4) basal diet + 1% A. bisporus + L. casei (107 colony-forming units/g) (MP + Pro group). The results demonstrated that oral administration of A. bisporus + L. casei significantly (P < 0.05) upregulated the expression of growth-related genes (gh and igf1). Similar results were observed for expression of mucosal immune-related genes (tnf-alpha, lyz, and il1b) and for antioxidant-related genes (sod, cat) in zebrafish fed A. bisporus + L. casei (P < 0.05). Also, nonspecific skin mucus immune parameters in the MP + Pro group were significantly (P < 0.05) higher than those in the MP, Pro, and control groups. These results also demonstrate the potential of combined administration of A. bisporus and L. casei as a beneficial feed additive in aquaculture.

1992-07-01·Journal of Applied Bacteriology

The use of immobilized lectins in the separation of Staphylococcus aureus, Escherichia coli, Listeria and Salmonella spp. from pure cultures and foods

Article

作者: R.G. Kroll ; Shona Campbell ; R.A. Patchett ; M.J. Payne

Lectins from Helix pomatia, Canavalia ensiformis, Agaricus bisporus and Triticum vulgaris agglutinated cultures of Staphylococcus aureus, Escherichia coli, Listeria and Salmonella spp. This agglutination was specific as it was inhibited (except with A. bisporus lectin) by the competing sugar substrates. The ability of three of these lectins, immobilized on a variety of supports, to separate these micro‐organisms from pure cultures was investigated. Immobilization of the lectins on magnetic microspheres was the most effective method. Immobilized T. vulgaris lectin bound 87–100% of cells from cultures of L. monocytogenes, 80–100% of Staph. aureus, 33–45% of Salmonella spp. and 42–77% of E. coli. The A. bisporus lectin bound 31–63% of cells in cultures of L. monocytogenes, 83% of Staph. aureus but only 3–5% of the salmonella cells. Similarly H. pomatia lectin bound >92% of Staph. aureus and 64% of L. monocytogenes cells but was poor at binding the Gram‐negative organisms. This preference for binding Gram‐positive organisms was confirmed when mixed cultures were studied. The T. vulgaris lectin was effective in removing L. monocytogenes (43%) and Staph. aureus (26%) from diluted milk and Salmonella (31–54%) from raw egg. Agaricus bisporus lectin removed L. monocytogenes from undiluted milk (10–47%) or ground beef (32–50%).

100 项与双孢蘑菇提取物相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
前列腺腺癌	临床2期	美国	City of Hope National Medical Center	2021-05-10
前列腺腺癌	临床2期	美国	National Cancer Institute	2021-05-10
遗传性前列腺癌7型	临床2期	美国	National Cancer Institute	2021-05-10
遗传性前列腺癌7型	临床2期	美国	City of Hope National Medical Center	2021-05-10
复发性前列腺癌	临床2期	美国	National Cancer Institute	2021-05-10
复发性前列腺癌	临床2期	美国	City of Hope National Medical Center	2021-05-10
涎腺多形性腺瘤	临床2期	美国	City of Hope National Medical Center	2021-05-10
涎腺多形性腺瘤	临床2期	美国	National Cancer Institute	2021-05-10
非转移性前列腺癌	药物发现	美国	National Cancer Institute	2009-01-29
乳腺癌	药物发现	美国	National Cancer Institute	2008-06-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00779168 (ASCO_GU2013)	临床1期	非转移性前列腺癌	36	White button mushroom (WBM) powder tablets	(餘顧製憲鹽艱簾遞繭遞) = 襯淵壓壓鏇獵鏇衊淵蓋窪獵衊壓窪顧願積壓顧 (壓壓壓糧壓鹽願鹹齋鹽, 4% ~ 27%)	-	2013-02-20
ARVO2009	N/A	-	-	5-Fluorouracil	夢觸獵夢鹽鹹構繭觸蓋(選淵範積淵範築廠廠襯) = 鬱憲獵構顧窪艱齋網糧醖顧艱願艱遞憲廠襯獵 (積艱簾願簾餘餘淵觸衊 )	积极	2009-04-01
ARVO2009	N/A	-	-	Agaricus bisporus lectin	夢觸獵夢鹽鹹構繭觸蓋(選淵範積淵範築廠廠襯) = 壓製壓廠壓糧願鬱衊繭醖顧艱願艱遞憲廠襯獵 (積艱簾願簾餘餘淵觸衊 )	积极	2009-04-01