LY-178002(LY-178002) - 药物靶点：5-LOX x PLA2 x PLA2G2A_专利_临床

概要

基本信息

药物类型

小分子化药

别名

LY178002、LY-178002

靶点

5-LOX x PLA2 x PLA2G2A

作用方式

抑制剂

作用机制

5-LOX抑制剂(5-脂氧合酶抑制剂)、PLA2抑制剂(磷脂酶A2抑制剂)、PLA2G2A抑制剂(IIA型磷脂酶A2抑制剂)

治疗领域

皮肤和肌肉骨骼疾病神经系统疾病心血管疾病+ [1]

在研适应症-

非在研适应症

关节炎炎症缺血性脑损伤

原研机构

Eli Lilly & Co.

在研机构-

非在研机构

Lilly Research Laboratories

Eli Lilly & Co.

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C18H25NO2S

InChIKeyBUDGLLLMROWLOB-UHFFFAOYSA-N

CAS号107889-32-7

关联

100 项与 LY-178002 相关的临床结果

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100 项与 LY-178002 相关的转化医学

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100 项与 LY-178002 相关的专利（医药）

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8

项与 LY-178002 相关的文献（医药）

1997-07-01·Tetrahedron, asymmetry

Substrate specificity of the kinetic resolution of sulfides by enantioselective sulfoxide formation

作者: Jill A Panetta ; Michael L Phillips

The kinetic resolution of tazofelone (I) has been reported.The resolution of this sulfide was accomplished via enantioselective sulfoxide formation with tert-Bu hydroperoxide in the presence of a chiral tartrate/titanium complex.The resolution was performed on analogs of compound I in order to explore the substrate specificity of the kinetic resolutionThese experiments have shown that the success of the enantioselective oxidation of this sulfide by tert-Bu hydroperoxide is greatly influenced by the nature of the neighboring amide functionality.

1994-11-01·Annals of the New York Academy of Sciences2区 · 综合性期刊

Neuroprotection by Antioxidants in Models of Global and Focal Ischemia

2区 · 综合性期刊

Review

作者: Jill A. Panetta ; James A. Clemens

The authors have investigated the effects of several antioxidants for their ability to protect against brain damage in models of transient cerebral ischemia.Their results demonstrate that several antioxidants have dramatic protective effects in models of transient cerebral ischemia.However, merely possessing antioxidant activity alone does not confer neuroprotective activity on a compoundOne or more addnl. properties are required such as the ability to gain access to the cellular compartment where the damage from ROS is taking place.

1994-09-01·TETRAHEDRON LETTERS

Synthesis of 4-thiazolidinones from rhodanines by thiocarbonyl removal

作者: Marvin M. Hansen ; Allen R. Harkness

Slow addition of rhodanines to excess zinc dust in acetic acid at reflux gave 4-thiazolidinones.Identification of dimeric byproducts led to development of a procedure to suppress their formation.

100 项与 LY-178002 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
关节炎	临床前	美国	Lilly Research Laboratories	1989-06-01
炎症	药物发现	美国	Eli Lilly & Co.	1986-08-08
缺血性脑损伤	药物发现	美国	Eli Lilly & Co.	1986-08-08