Ascorbyl gamolenate(Ascorbyl gamolenate) - 药物靶点：AKR1B1_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ascorbyl-GLA、Ascorbyl-gamma-linolenic acid

+ [1]

靶点

AKR1B1

作用机制

AKR1B1抑制剂(醛糖还原酶抑制剂)

治疗领域

神经系统疾病内分泌与代谢疾病

在研适应症-

非在研适应症

糖尿病性神经病变

原研机构

Scotia

在研机构-

非在研机构

Scotia Holdings PlcScotia

最高研发阶段终止临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C24H36O7

InChIKeyFLRQOWAOMJMSTP-JJTRIOAGSA-N

CAS号109791-32-4

关联

100 项与 Ascorbyl gamolenate 相关的临床结果

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100 项与 Ascorbyl gamolenate 相关的转化医学

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100 项与 Ascorbyl gamolenate 相关的专利（医药）

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16

项与 Ascorbyl gamolenate 相关的文献（医药）

2023-04-01·European review for medical and pharmacological sciences

Reduction of double chin without surgery using ascorbic acid and ascorbyl-palmitate solution: a clinical study.

Article

作者: Di Carmine, M ; Marchetti, M ; Amore, R ; Qorri, E ; Amuso, D ; Scarano, A ; Greco Lucchina, A

OBJECTIVEThe purpose of the present clinical study is to assess the effectiveness of a lipolytic solution containing sodium salt of ascorbic acid at 0.24% and a surfactant agent at 0.020% ascorbyl-palmitate (SAP) for the treatment of double chin.PATIENTS AND METHODSA total of 10 healthy adult subjects affected by double chin (8 female and 2 male) were evaluated in the present investigation. The patients were admitted to a total of 4 sessions, with biweekly procedures, without no other active agents addiction.RESULTSIn all the subjects a reduction of the convexity of the chin after the treatment with SAP was observed. Improvement in submental appearance was achieved in 90% (9/10) of the patients. One patient did not see any improvement in submental appearance after two section treatments and withdrew from the treatment.CONCLUSIONSIn conclusion, in the present study, a new adipocytolytic solution consisting of sodium ascorbate mixed with ascorbyl-palmitate was used with success as a surfactant agent for the treatment of double chin.

2022-02-01·Aesthetic Plastic Surgery

Invited Response on: A New Treatment for Local Adiposity With Ascorbic Acid and Ascorbyl-palmitate Solution: Clinical and Histological Study

Letter

作者: Ferraro, G ; Sbarbati, A ; Iorio, E L ; Scarano, A ; Amore, R ; Amuso, D

2022-02-01·Aesthetic Plastic Surgery

A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study

Letter

作者: Dong, Xinhang ; Jin, Xiaolei ; Zhang, Mingzi

100 项与 Ascorbyl gamolenate 相关的药物交易

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