IMA-202

Interim data update at SITC for ongoing ACTengine®IMA203 trial targeting PRAME demonstrated clinical responses across multiple solid tumor typesduring dose escalation phase Immaticstoinitiate three expansion cohorts for IMA203 targeting PRAME: monotherapy, combination with checkpoint inhibitor, and next-generation ACT approach Cashand cash equivalents as well as other financial assets of $200.6million1(€173.2million)as of September 30, 2021,funding company operations into 2023 Tuebingen, Germany and Houston, TX, November16, 2021 – ImmaticsN.V. (NASDAQ: IMTX; “Immatics”), a clinical-stage biopharmaceutical company active in the discovery and development of T cell redirecting cancer immunotherapies, today reported its financial results for the quarter ended September 30, 2021, and provided a business update on its progress over the reporting period. “The unprecedented objective response rate we have observed during early dose escalation in the ACTengine® IMA203 trial, encourages us to double down on our development strategy of our programs targeting PRAME,” said Harpreet Singh, Ph.D., CEO at Immatics. “Following determination of target dose, we will start a concerted effort in early 2022 with multiple levers to pull to deliver durability of response. This will include deploying ACTengine® IMA203 (1) as monotherapy at target dose, (2) in combination with a checkpoint inhibitor, (3) as an efficacy-enhanced next-gen TCR-T approach IMA203CD8 and (4) also now being able to offer IMA203 to patients with fewer lines of pre-treatments or less disease burden. We look forward to providing updates on these clinical outcomes throughout 2022.” ThirdQuarter 2021 and Subsequent Company Progress Adoptive Cell Therapy Programs ACTengine® IMA203 – On November 13, Dr. Martin Wermke, coordinating investigator of the Phase 1 trial with IMA203 targeting PRAME, presented updated clinical data as a late-breaking oral presentation at the 36th Annual Meeting of the Society for Immunotherapy of Cancer (SITC). The dose escalation phase of the trial for IMA203 is ongoing with dose level 3 completed at doses below 1 billion transduced cells in a heavily pre-treated patient population. In 15 out of 16 evaluable patients (94%), treatment with IMA203 achieved disease control and tumor shrinkage was observed in 14 out of 16 patients (88%). Objective responses (partial responses according to RECIST 1.1) were observed in 8 out of 16 patients (50%) across multiple solid cancer indications. 8 out of 13 patients (62%) treated at dose levels 2 and 3 had objective partial responses. Adverse events remained transient and manageable with no high-grade cytokine release syndrome or neurological toxicities observed. No dose limiting toxicities (DLTs) were observed since the previous data release on March 17, 2021. The data also revealed high T cell engraftment and persistence along with clinical responses which were associated with tumor infiltration. Patient recruitment to the 4th and highest dose level (up to approximately 2.5 billion total transduced cells) for the ACTengine® IMA203 trial is ongoing. Immatics plans to expand the IMA203 study to three Phase 1b (dose expansion) study cohorts including IMA203 as a monotherapy, IMA203 in combination with an immune checkpoint inhibitor and IMA203 cells co-transduced with a CD8 co-receptor, called IMA203CD8. ACTengine® IMA203CD8 – Immatics entered into an exclusive license agreement with Baylor College of Medicine (BCM) in Houston, Texas, for the development of next-generation adoptive cell therapies (ACT). BCM conducted foundational research for the use of CD8 co-receptor expression in an ACT setting. Through this agreement with BCM, Immatics gains access to pioneering work in the field of CD8αβ co-receptor expression to develop its next-generation ACT approaches. The agreement underscores Immatics’ long-term strategy to access innovative science and technologies to enhance the tolerability, potency, and ease of use of its TCR-T product candidates. Immatics presented preclinical proof-of-concept data on its next-generation ACTengine® IMA203CD8 program in a poster presentation at the 2021 SITC Annual Meeting on November 12. The data demonstrated that equipping IMA203-T cells with CD8αβ, a T cell co-receptor, enhances anti-tumor activity of the engineered T cells. Immatics’ IMA203CD8 candidate showed functional superiority among 20 tested CD8 constructs including CD8α. IND submission for IMA203CD8 as part of the Phase 1b study expansion cohort is expected in the first half of 2022. ACTengine® IMA201 and IMA202 – The dose escalation Phase 1a study of the clinical ACTengine® programs, IMA201 and IMA202, continues to advance with IMA202 at target dose level 3 and IMA201 at dose level 2. 12 heavily pre-treated patients have been treated with product candidates IMA201 and IMA202. 8 out of 12 patients showed disease control, and tumor shrinkage was observed in 4 patients. All adverse events for IMA201 and IMA202 continue to be transient and manageable with no DLTs observed. The next step in the IMA201 and IMA202 trials is to complete dose escalation including target dose (DL3). ACTengine® IMA204 – The fourth program of the different ACTengine® IMA200 TCR-T programs, IMA204, is directed at the novel tumor stroma target COL6A3 exon 6 expressed in a large variety of solid cancers. IMA204 is utilizing a next-generation CD8-independent T cell receptor. IND-enabling studies with IMA204 are being completed. Submission of the IND application for IMA204 is expected in 2022. TCR Bispecifics Program TCER® IMA401 – IMA401 is an antibody-like, “off-the-shelf” biologic directed against a high-density peptide target derived from MAGEA4/8. Submission of a Clinical Trial Application (CTA) is planned in the fourth quarter of 2021 and patient recruitment will be initiated in the first half 2022. TCER® IMA402 – Immatics presented preclinical proof-of-concept data from its TCER® program, IMA402, directed against PRAME, at the PEGS Boston Protein Engineering and Cell Therapy Summit in May. In additional pre-clinical studies, TCER® IMA402 designed with a low-affinity T cell recruiter demonstrated superior tumor control than analogous TCER® molecules with higher-affinity T cell recruiter domains. Production of GMP material for a Phase 1 clinical study is planned in 2022. Third Quarter 2021 Financial Results Cash Position: Cash and cash equivalents as well as other financial assets total €173.2 million ($200.6 million1) as of September 30, 2021, compared to €192.8 million ($223.2 million1) as of June 30, 2021. Revenue: Total revenue, consisting of revenue from collaboration agreements, was €6.4 million ($7.4 million1) for the three months ended September 30, 2021, compared to €7.9 million ($9.1 million1) for the three months ended September 30, 2020. Research and Development Expenses: R&D expenses were €21.2 million ($24.5 million1) for the three months ended September 30, 2021, compared to €17.5 million ($20.3 million1) for the three months ended September 30, 2020. The increase is mainly due to expanded clinical activities for the ACTengine® IMA200 series, as well as GMP manufacturing for the TCER® compound, IMA401. General and Administrative Expenses: G&A expenses were €8.3 million ($9.6 million1) for the three months ended September 30, 2021, compared to €9.2 million ($10.7 million1) for the three months ended September 30, 2020. The decrease is mainly due to one-time expenses in connection with the listing of the Company in 2020. Net Loss: Net loss was €27.2 million ($31.5 million1) for the three months ended September 30, 2021, compared to €164.0 million ($189.9 million1) for the three months ended September 30, 2020. The decrease is mainly due to a one-time share listing expense of €152.8 million ($176.9 million) in connection with the listing of the Company in 2020. Upcoming InvestorConferences Jefferies Global Healthcare Conference – November 16-18, 2021 Piper Sandler 33rd Annual Healthcare Conference – November 30 - December 2, 2021 11th Annual SVB Leerink Global Healthcare Conference – February 14 – 18, 2022 To see the full list of events and presentations, visit . Full financial statements can be found in the current report on Form 6-K filed with the Securities and Exchange Commission (SEC) and published on the SEC website under . 1 All amounts translated using the exchange rate published by the European Central Bank in effect as of September 30, 2021 (1 EUR = 1.1579 USD). About Immatics’ PRAME Programs Immatics’ PRAME programs are directed against an HLA-A*02-presented peptide derived from preferentially expressed antigen in melanoma (PRAME), a protein frequently expressed in a large variety of solid cancers – such as uterine carcinoma, synovial sarcoma, melanoma, ovarian carcinoma, uveal melanoma, squamous NSCLC, breast carcinoma and HNSCC – thereby supporting the programs’ potential to address a broad cancer patient population. PRAME demonstrates a high target peptide density per tumor cell and is homogenously expressed in tumor tissue. The peptide has been identified and characterized by Immatics’ proprietary mass spectrometry-based target discovery platform XPRESIDENT®. Through its proprietary TCR discovery and engineering platform XCEPTOR®, the Company has generated a highly specific T cell receptor (TCR) against this target for its TCR-based cell therapy approach, ACTengine® IMA203, and its TCR Bispecifics pipeline, TCER® IMA402. Both therapeutic modalities have distinct attributes and mechanisms of actions suitable for cancer patients at different disease stages and tumor types. About ACTengine® IMA200 programs Each of the product candidates of the IMA200 programs is based on Immatics’ proprietary ACTengine® approach in which the patient’s own T cells are genetically engineered to express a novel, proprietary TCR directed against a defined cancer target. The modified T cells are then reinfused into the patient to attack the tumor, an approach also known as TCR-T. ACTengine® programs IMA201, IMA202 and IMA203 are currently in clinical development for the treatment of solid tumor indications, both in the US and in Germany. All ACTengine® product candidates can be rapidly manufactured utilizing a proprietary manufacturing process designed to enhance T cell engraftment and persistence in vivo. The ACTengine® T cell products are manufactured at the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory in collaboration with UTHealth and the associated programs are co-funded by the Cancer Prevention and Research Institute of Texas (CPRIT). About TCER® Immatics’ TCER® molecules are antibody-like “off-the-shelf” biologics that leverage the body’s immune system by redirecting and activating T cells towards cancer cells expressing a specific tumor target. To do so, the proprietary biologics are engineered to have two binding regions. The first region contains an affinity- and stability-improved TCR that binds specifically to the cancer target on the cell surface presented by a human leukocyte antigen (HLA) molecule. The second region is derived from an antibody domain that recruits endogenous T cells to the tumor to become activated. The design of the TCER® molecules enables the activation of any T cell in the body to attack the tumor, regardless of the T cells’ intrinsic specificity. In addition, the TCER® molecule has a Fc-part conferring stability, half-life extension and enhanced manufacturability. About Immatics Immatics combines the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling a robust and specific T cell response against these targets. This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. We are committed to delivering the power of T cells and to unlocking new avenues for patients in their fight against cancer. Immatics intends to use its website as a means of disclosing material non-public information. For regular updates you can also follow us on Twitter and LinkedIn. Forward-Looking Statements Certain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events or Immatics’ future financial or operating performance. For example, statements concerning the timing of product candidates and Immatics’ focus on partnerships to advance its strategy are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “intend”, “will”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Immatics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in filings with the SEC. Nothing in this presentation should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. Immatics undertakes no duty to update these forward-looking statements. For more information, please contact: For Media Inquiries Investor Relations Contact Jacob Verghese or Stephanie May John Mullaly Trophic Communications LifeSci Advisors Phone: +49 89 2388 7731 Phone: +1 617-429-3548 immatics@trophic.eu or jmullaly@lifesciadvisors.com Immatics N.V. Anja Heuer Jordan Silverstein Director, Corporate Communications Head of Strategy Phone: +49 89 540415-606 Phone: +1 281 810 7545 media@immatics.com InvestorRelations@immatics.com Unaudited Condensed Consolidated Statement of Financial Position of Immatics N.V. As of September 30, 2021 December 31, 2020 (Euros in thousands) Assets Current assets Cash and cash equivalents 161,294 207,530 Other financial assets 11,920 24,448 Accounts receivable 725 1,250 Other current assets 6,197 5,763 Total current assets 180,136 238,991 Non-current assets Property, plant and equipment 9,498 7,868 Intangible assets 1,277 914 Right-of-use assets 7,281 6,149 Other non-current assets 719 724 Total non-current assets 18,775 15,655 Total assets 198,911 254,646 Liabilities and shareholders' deficit Current liabilities Provisions 3,075 51 Accounts payable 11,842 10,052 Deferred revenue 61,877 46,600 Other financial liabilities 26,257 16,869 Lease liabilities 2,600 1,881 Other current liabilities 1,469 2,025 Total current liabilities 107,120 77,478 Non-current liabilities Deferred revenue 52,232 85,475 Lease liabilities 4,398 4,306 Total non-current liabilities 56,630 89,781 Shareholders' equity Share capital 629 629 Share premium 560,441 538,695 Accumulated deficit (521,026) (444,478) Other reserves (4,883) (7,459) Total shareholders' equity 35,161 87,387 Total liabilities and shareholders' equity 198,911 254,646 Unaudited Condensed Consolidated Statement of Loss of Immatics N.V. Three months ended September 30, Nine months ended September 30, 2021 2020 2021 2020 (Euros in thousands, except share and per share data) (Euros in thousands, except share and per share data) Revenue from collaboration agreements 6,443 7,871 19,036 21,807 Research and development expenses (21,225) (17,485) (64,613) (46,236) General and administrative expenses (8,266) (9,215) (24,968) (25,488) Other income 47 32 311 232 Operating result (23,001 (18,797) (70,234) (49,685) Financial income 1,421 1,188 4,474 1,943 Financial expenses (171) (6,717) (1,400) (6,499) Change in fair value of warrant liabilities (5,452) 13,157 (9,388) 13,157 Share listing expense - (152,787) - (152,787) Financial result (4,202) (145,159) (6,314) (144,186) Loss before taxes (27,203) (163,956) (76,548) (193,871) Taxes on income - - - - Net loss (27,203) (163,956) (76,548) (193,871) Attributable to: Equity holders of the parent (27,203) (163,956) (76,548) (193,314) Non-controlling interest - - - (557) Net loss (27,203) (163,956) (76,548) (193,871) Net loss per share - basic and diluted (0.43) (2.61) (1.22) (4.49) Weighted average shares outstanding - basic and diluted 62,911,465 62,908,617 62,909,797 43,032,098 Unaudited Condensed Consolidated Statement of Comprehensive Loss of Immatics N.V. Three months ended September 30, Nine months ended September 30, 2021 2020 2021 2020 (Euros in thousands) (Euros in thousands) Net Loss (27,203) (163,956) (76,548) (193,871) Other comprehensive loss Items that may be reclassified subsequently to profit or loss, net of tax - - - - Currency translation differences from foreign operations 1,252 (3,487) 2,576 (3,387) Total comprehensive loss for the period (25,951) (167,443) (73,972) (197,258) Attributable to: Equity holders of the parent (25,951) (167,443) (73,972) (196,701) Non-controlling interest - - - (557) Total comprehensive loss for the period (25,951) (167,443) (73,972) (197,258) Unaudited Condensed Consolidated Statement of Cash Flows of Immatics N.V. Nine months ended September 30, 2021 2020 (Euros in thousands) Cash flows from operating activities Loss before taxation (76,548) (193,871) Adjustments for: Interest income (102) (1,072) Depreciation and amortization 3,967 3,466 Interest expense 213 188 Share listing expense - 152,787 Equity settled share-based payment 21,671 15,031 MD Anderson compensation expense - 45 Decrease in other liabilities resulting from share appreciation rights - (1,893) Payment related to share-based compensation awards previously classified as equity-settled - (4,322) Net foreign exchange differences 408 (1,425) Change in fair value of warrant liabilities 9,388 (13,157) Changes in working capital Decrease/(increase) in accounts receivable 525 (92) Increase in other assets (390) (2,212) (Increase) in accounts payable and other current liabilities (14,233) (14,180) Interest received 144 1,030 Interest paid (213) (188) Net cash used in operating activities (55,170) (59,865) Cash flows from investing activities Payments for property, plant and equipment (3,277) (5,864) Cash paid for investments classified in Other financial assets (53,887) (58,482) Cash received from maturity of investments classified in Other financial assets 66,972 48,881 Payments for intangible assets (487) (86) Proceeds from disposal of property, plant and equipment - - Net cash (used in)/provided by investing activities 9,321 (15,551) Cash flows from financing activities Proceeds from issuance of shares to equity holders of the parent 75 209,369 Payments for leases (2,102) (1,633) Net cash used in financing activities (2,027) 207,736 Net decrease in cash and cash equivalents (47,876) 132,320 Cash and cash equivalents at beginning of period 207,530 103,353 Effects of exchange rate changes on cash and cash equivalents 1,640 (1,997) Cash and cash equivalents at end of period 161,294 233,676 Unaudited Condensed Consolidated Statement of Changes in Shareholders’ equity (deficit) of Immatics N.V. (Euros in thousands) Share capital Share premium Accumulated deficit Other reserves Total equity (deficit) attributable to shareholders of the parent Non-controlling interest Total share-holders' equity (deficit) Balance as of January 1, 2020 1,164 190,945 (233,194) (770) (41,855) 1,020 (40,835) Other comprehensive loss - - - (3,387) (3,387) - (3,387) Net loss - - (193,314) - (193,314) (557) (193,871) Comprehensive loss for the year - - (193,314) (3,387) (196,701) (557) (197,258) Reorganization (833) 833 - - - - - Issue of share capital MD Anderson Share Exchange 7 501 - - 508 (508) - PIPE Financing, net of transaction costs 104 89,749 - - 89,853 - 89,853 ARYA Merger, net of transaction costs 180 237,477 - - 237,657 - 237,657 SAR conversion 7 (7) - - - - - Total issuance of share capital 298 328,553 - - 328,018 (508) 327,510 Equity-settled share-based compensation - 15,031 - - 15,031 - 15,031 Payment related to share-based compensation awards previously classified as equity-settled - (4,322) - - (4,322) - (4,322) MD Anderson milestone compensation expense - - - - - 45 45 Balance as of September 30, 2020 629 530,207 (426,508) (4,157) (100,171) - (100,171) Balance as of January 1, 2021 629 538,695 (444,478) (7,459) 87,387 - 87,387 Other comprehensive income - - - 2,576 2,576 - 2,576 Net loss - - (76,548) - (76,548) - (76,548) Comprehensive income/(loss) for the year - - (76,548) 2,576 (73,972) - (73,972) Equity-settled share-based compensation - 21,671 - - 21,671 - 21,671 Share options exercised 0 75 - - 75 - 75 Balance as of September 30, 2021 629 560,441 (521,026) (4,883) 35,161 - 35,161 Attachment PDF Version

ACTengine® patient recruitment remains on track; as ofend of July, a total of 27 patients have been treated with IMA201, IMA202 or IMA203 across different cancer indications TCR Bispecifics pipeline advancing with progress towards clinical trial initiationof IMA401 and preclinical proof-of-concept for second TCER®molecule IMA402 Cashand cash equivalents as well as Other financial assets of $229.1million1(€192.8million)as of June 30, 2021,funding company operations into 2023 Tuebingen, Germany and Houston, TX, August 10, 2021 – ImmaticsN.V. (NASDAQ: IMTX; “Immatics”), a clinical-stage biopharmaceutical company active in the discovery and development of T cell redirecting cancer immunotherapies, today reported its financial results for the quarter ended June 30, 2021 and provided a business update on its progress over the reporting period. “An important development during the second quarter of 2021 was a significant increase in patient enrollment for our ACTengine® programs,” said Harpreet Singh, Ph.D., CEO of Immatics. “Following the positive initial results we provided in the first quarter, we now look forward to announcing more advanced data including safety, biological activity and the assessment of anti-tumor activity for a range of different cancer indications in the second half of 2021.” “In addition to the upcoming clinical data for our ACTengine® trials, we are excited to move our second therapeutic modality towards the clinic,” added Carsten Reinhardt, M.D., Ph.D., Chief Development Officer at Immatics. “We are encouraged by the entirety of the IMA401 data set, which following discussions with regulatory authorities puts us in a strong position to submit our IMA401 Clinical Trial Application during the fourth quarter of 2021. Our TCER® pipeline is further strengthened by our second TCR Bispecifics program, IMA402, for which we recently presented preclinical proof-of-concept data.” Second Quarter 2021 and Subsequent Company Progress Adoptive Cell Therapy Programs ACTengine® IMA200 series – Patient recruitment remains on track and the additional trial sites initiated in Europe and the US have supported the acceleration of recruitment. As of end of July, 27 patients have been treated in the IMA200 series. The first-in-human basket trials for IMA201, IMA202 and IMA203 include patients with recurrent and/or refractory solid cancers utilizing TCR-engineered T cells (TCR-T) directed against the cancer targets MAGEA4/A8, MAGEA1 and PRAME, respectively. In March 2021, Immatics reported initial safety and biological data as well as data showing first clinical anti-tumor activity for 10 patients enrolled in these trials. Patients were treated at initial dose levels below one billion transduced cells, which was presumed to be sub-therapeutic as per data published from across the industry. The next data update, which will cover safety, biological activity, and the assessment of anti-tumor activity across different cancer indications, including patients treated at higher dose levels (dose levels 2 and 3), will be provided by the company within the second half of 2021. TCR Bispecifics Programs IMA401 – Immatics has discussed the proposed clinical trial design for its first TCER® program IMA401, as well as the preclinical data package covering safety and efficacy data in a scientific advisory meeting2 with the Paul-Ehrlich Institute, the German regulatory authority. The company also completed the first Good Manufacturing Practices (GMP) production batch delivering a high production yield. IMA401 remains on track for submission of a CTA in the fourth quarter of 2021 and patient recruitment will be initiated in the first half 2022. IMA402 – The company presented preclinical proof-of-concept data on IMA402 at the 17th Annual PEGS Boston Protein Engineering and Cell Therapy Summit in May. IMA402 is directed against a peptide derived from the cancer target PRAME, a protein that is frequently expressed in many solid cancers, thereby supporting the program’s potential to address a broad range of cancer patients and indications. Data demonstrated tumor cell killing in vitro and complete regressions of established tumors in an in vivo tumor model. Immatics has selected a lead candidate for the clinical program and initiated manufacturing activities. Corporate Development As of July 1, 2021, Immatics adopted a one-tier structure for its Board of Directors. As part of this process, the company’s CEO Harpreet Singh, Ph.D., has joined the Board. Friedrich von Bohlen und Halbach, Ph.D., was appointed as successor of Christof Hettich, L.L.D. Dr. von Bohlen und Halbach is Managing Partner and co-founder of dievini Hopp BioTech Holding, managing the investments of Dietmar Hopp and family. Second Quarter 2021 Financial Results Cash Position: Cash and cash equivalents as well as Other financial assets total €192.8 million ($229.1 million1) as of June 30, 2021, compared to €216.7 million ($257.5 million1) as of March 31, 2021. Revenue: Total revenue, consisting of revenue from collaboration agreements, was €5.2 million ($6.2 million1) for the three months ended June 30, 2021, compared to €6.9 million ($8.2 million1) for the three months ended June 30, 2020. Research and Development Expenses: R&D expenses were €20.3 million ($24.1 million1) for the three months ended June 30, 2021, compared to €16.5 million ($19.7 million1) for the three months ended June 30, 2020. The increase is mainly due to expanded clinical activities for the ACTengine® IMA200 series, as well as GMP manufacturing for the TCER® compound, IMA401. General and Administrative Expenses: G&A expenses were €8.3 million ($9.9 million1) for the three months ended June 30, 2021, compared to €10.1 million ($12.0 million1) for the three months ended June 30, 2020. The decrease is mainly due to one-time expenses in connection with the listing of the Company in 2020. Net Loss: Net loss was €23.8 million ($28.3 million1) for the three months ended June 30, 2021, compared to €21.3 million ($25.3 million1) for the three months ended June 30, 2020. Upcoming InvestorConferences BTIG Virtual Biotechnology Conference – August 9-10, 2021 Goldman Sachs London Biotech Symposium – September 7, 2021 Jefferies London Healthcare Conference – November 16-18, 2021 To see the full list of events and presentations, visit . Full financial statements can be found in the current report on Form 6-K filed with the Securities and Exchange Commission (SEC) and published on the SEC website under . 1 All amounts translated using the exchange rate published by the European Central Bank in effect as of June 30, 2021 (1 EUR = 1.1884 USD). 2 in Europe, equivalent to a pre-IND meeting at FDA. About ACTengine® IMA200 series Each of the product candidates of the IMA200 series is based on Immatics’ proprietary ACTengine® approach in which the patient’s own T cells are genetically engineered to express a novel, proprietary TCR directed against a defined cancer target. The modified T cells are then reinfused into the patient to attack the tumor, an approach also known as TCR-T. ACTengine® programs IMA201, IMA202 and IMA203 are currently in clinical development for the treatment of solid tumor indications, both in the US and in Germany. All ACTengine® product candidates can be rapidly manufactured utilizing a proprietary manufacturing process designed to enhance T cell engraftment and persistence in vivo. The ACTengine® T cell products are manufactured at the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory in collaboration with UTHealth and co-funded by the Cancer Prevention and Research Institute of Texas (CPRIT). About TCER® Immatics’ TCER® molecules are antibody-like “off-the-shelf” biologics that leverage the body’s immune system by redirecting and activating T cells towards cancer cells expressing a specific tumor target. To do so, the proprietary biologics are engineered to have two binding regions. The first region contains an affinity- and stability-improved TCR that binds specifically to the cancer target on the cell surface presented by a human leukocyte antigen (HLA) molecule. The second region is derived from an antibody domain that recruits endogenous T cells to the tumor to become activated. The design of the TCER® molecules enables the activation of any T cell in the body to attack the tumor, regardless of the T cells’ intrinsic specificity. In addition, the TCER® molecule has a Fc-part conferring stability, half-life extension and enhanced manufacturability. About Immatics Immatics combines the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling a robust and specific T cell response against these targets. This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. We are committed to delivering the power of T cells and to unlocking new avenues for patients in their fight against cancer. Immatics intends to use its website as a means of disclosing material non-public information. For regular updates you can also follow us on Twitter and LinkedIn. Forward-Looking Statements Certain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events or Immatics’ future financial or operating performance. For example, statements concerning the timing of product candidates and Immatics’ focus on partnerships to advance its strategy are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “intend”, “will”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Immatics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in filings with the SEC. Nothing in this presentation should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. Immatics undertakes no duty to update these forward-looking statements. For more information, please contact: For Media Inquiries Investor Relations Contact Jacob Verghese or Stephanie May Eric Goldstein or John Mullaly Trophic Communications LifeSci Advisors Phone: +49 89 2388 7731 Phone: +1 646 791 9729 or +1 617-429-3548 immatics@trophic.eu egoldstein@lifesciadvisors.com or jmullaly@lifesciadvisors.com Immatics N.V. Anja Heuer Jordan Silverstein Director, Corporate Communications Head of Strategy Phone: +49 89 540415-606 Phone: +1 281 810 7545 media@immatics.com InvestorRelations@immatics.com Unaudited Condensed Consolidated Statement of Financial Position of Immatics N.V. As of June 30, 2021 December 31, 2020 (Euros in thousands) Assets Current assets Cash and cash equivalents 160,093 207,530 Other financial assets 32,712 24,448 Accounts receivable 718 1,250 Other current assets 4,815 5,763 Total current assets 198,338 238,991 Non-current assets Property, plant and equipment 8,747 7,868 Intangible assets 1,262 914 Right-of-use assets 7,313 6,149 Other non-current assets 845 724 Total non-current assets 18,167 15,655 Total assets 216,505 254,646 Liabilities and shareholders' deficit Current liabilities Provisions 1,960 51 Accounts payable 9,407 10,052 Deferred revenue 57,998 46,600 Lease liabilities 2,321 1,881 Other current liabilities 1,442 2.025 Total current liabilities 73,128 60,609 Non-current liabilities Deferred revenue 62,201 85,475 Lease liabilities 4,736 4,306 Total non-current liabilities 66,937 89,781 Shareholders' equity Share capital 629 629 Share premium 589,609 573,339 Accumulated deficit (507,663) (462,253) Other reserves (6,135) (7,459) Total shareholders' equity 76,440 104,256 Total liabilities and shareholders' equity 216,505 254,646 Unaudited Condensed Consolidated Statement of Loss of Immatics N.V. Three months ended June 30, Six months ended June 30, 2021 2020 2021 2020 (Euros in thousands, except share and per share data) (Euros in thousands, except share and per share data) Revenue from collaboration agreements 5,189 6,896 12,592 13,936 Research and development expenses (20,340) (16,505) (43,389) (28,751) General and administrative expenses (8,271) (10,076) (16,702) (16,264) Other income 26 86 265 200 Operating result (23,396) (19,599) (47,234) (30,879) Financial income 213 437 3,101 1,083 Financial expenses (629) (2,164) (1,277) (110) Financial result (416) (1,727) 1,824 973 Loss before taxes (23,812) (21,326) (45,410) (29,906) Taxes on income - - - - Net loss (23,812) (21,326) (45,410) (29,906) Attributable to: Equity holders of the parent (23,812) (21,043) (45,410) (29,349) Non-controlling interest - (283) - (557) Net loss (23,812) (21,326) (45,410) (29,906) Net loss per share - basic and diluted (0.38) (0.64) (0.72) (0.89) Weighted average shares outstanding - basic and diluted 62,909,095 33,093,838 62,908,945 33,093,838 Unaudited Condensed Consolidated Statement of Comprehensive Loss of Immatics N.V. Three months ended June 30, Six months ended June 30, 2021 2020 2021 2020 (Euros in thousands) (Euros in thousands) Net Loss (23,812) (21,326) (45,410) (29,906) Other comprehensive loss Items that may be reclassified subsequently to profit or loss, net of tax - - - - Currency translation differences from foreign operations (1,401) 791 1,324 99 Total comprehensive loss for the period (25,213) (20,535) (44,086) (29,807) Attributable to: Equity holders of the parent (25,213) (20,252) (44,086) (29,250) Non-controlling interest - (283) - (557) Total comprehensive loss for the period (25,213) (20,535) (44,086) (29,807) Unaudited Condensed Consolidated Statement of Cash Flows of Immatics N.V. Six months ended June 30, 2021 2020 (Euros in thousands) Cash flows from operating activities Loss before taxation (45,410) (29,906) Adjustments for: Interest income (87) (755) Depreciation and amortization 2,264 2,288 Interest expense 140 110 Equity settled share-based payment 16,270 6,928 MD Anderson compensation expense - 45 Increase in other liabilities resulting from share appreciation rights - 7,773 Cash-out related to share-based compensation previously classified as equity-settled - (4,322) Net foreign exchange differences 236 1 Changes in working capital Decrease in accounts receivable 532 530 Decrease/(increase) in other assets 902 (1,106) Increase in accounts payable and other current liabilities (11,363) (9,724) Interest received 54 510 Interest paid (140) (110) Net cash used in operating activities (36,602) (27,738) Cash flows from investing activities Payments for property, plant and equipment (1,912) (4,514) Cash paid for investments classified in Other financial assets (53,782) (32,859) Cash received from maturity of investments classified in Other financial assets 45,770 48,881 Payments for intangible assets (390) (36) Proceeds from disposal of property, plant and equipment 8 - Net cash (used in)/provided by investing activities (10,306) 11,472 Cash flows from financing activities Payments for leases (1,348) (1,168) Net cash used in financing activities (1,348) (1,168) Net decrease in cash and cash equivalents (48,256) (17,434) Cash and cash equivalents at beginning of period 207,530 103,353 Effects of exchange rate changes on cash and cash equivalents 819 137 Cash and cash equivalents at end of period 160,093 86,056 Unaudited Condensed Consolidated Statement of Changes in Shareholders’ equity (deficit) of Immatics N.V. (Euros in thousands) Share capital Share premium Accumulated deficit Other reserves Total equity (deficit) attributable to shareholders of the parent Non-controlling interest Total share-holders' equity (deficit) Balance as of January 1, 2020 1,164 190,945 (233,194) (770) (41,855) 1,020 (40,835) Other comprehensive loss - - - 99 99 - 99 Net loss - - (29,349) - (29,349) (557) (29,906) Comprehensive loss for the year - - (29,349) 99 (29,250) (557) (29,807) Equity-settled share-based compensation - 6,928 - - 6,928 - 6,928 Cash-out related to share-based compensation previously classified as equity-settled - (4,322) - - (4,322) - (4,322) MD Anderson milestone compensation expense - - - - - 45 45 Balance as of June 30, 2020 1,164 193,551 (262,543) (671) (68,499) 508 (67,991) Balance as of January 1, 2021 629 573,339 (462,253) (7,459) 104,256 - 104,256 Other comprehensive income - - - 1,324 1,324 - 1,324 Net loss - - (45,410) - (45,410) - (45,410) Comprehensive income/(loss) for the year - - (45,410) 1,324 (44,086) (44,086) Equity-settled share-based compensation - 16,270 - - 16,270 - 16,270 Balance as of June 30, 2021 629 589,609 (507,663) (6,135) 76,440 - 76,440 Attachment PDF Version