大西洋黄连木提取物(Pistacia atlantica extract)

概要

基本信息

药物类型

中药

别名

pistacia Mutica extract

靶点-

作用机制-

治疗领域

感染口颌疾病

在研适应症-

非在研适应症

牙龈炎

原研机构-

在研机构-

非在研机构

University of Tabriz

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

5

项与大西洋黄连木提取物相关的临床试验

IRCT20090804002288N17 / Suspended临床2/3期

Evaluation of the efficacy of the topical use of Pistacia atlantica oleoresin in the treatment of acute cutaneous leishmaniasis wound: a pilot randomized, double-blind, placebo-controlled clinical trial

开始日期2024-11-21

申办/合作机构

Academic Center for Education, Culture and Research

[+1]

IRCT20240601061969N1 / Suspended临床3期IIT

Investigating the effect of Pistacia atlantica cream in the treatment of wounds in diabetic patients, a double-blind clinical study

开始日期2024-08-05

申办/合作机构-

IRCT20240317061320N1 / Recruiting临床3期IIT

Investigating the effect of topical massage of Pistacia atlantica oil around the umbilical area of 2 to 8 weeks infants, on improvement of infantile colic

开始日期2024-04-20

申办/合作机构

Zanjan University of Medical Sciences

100 项与大西洋黄连木提取物相关的临床结果

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100 项与大西洋黄连木提取物相关的转化医学

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100 项与大西洋黄连木提取物相关的专利（医药）

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8

项与大西洋黄连木提取物相关的文献（医药）

2021-09-01·Phytotherapy Research2区 · 医学

Effectiveness of Pistacia atlantica on older adult knee osteoarthritis, a randomized triple blind clinical trial

2区 · 医学

Article

作者: Bakhtiary Far, Adel ; Moosazadeh, Mahmood ; Khamevar, Ali ; Saeedi, Majid ; Ebrahimzadeh, Mohammad Ali ; Yousefi, Seyde Sedighe ; Shayesteh Azar, Masoud

Osteoarthritis is the most common cause of disability and aging is the major risk factor. One of the low‐risk herbal medicines for reducing pain and inflammation in persian medicine is Pistacia atlantica gum. A triple‐blind placebo‐controlled clinical trial was performed in order to evaluate the efficacy of P. atlantica gum ointment on knee osteoarthritis in elderly people. A total of 60 patients were randomly allocated to two groups. The intervention group used 4% P. atlantica ointment and the control group used placebo, topically applied three times a day, for 8 weeks. The patients were evaluated before and after the intervention using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale. There were significant differences (p < .001) between two the groups in terms of joint stiffness and pain as well as function. Within groups, regarding the effect size (EF) in joint stiffness was 2.82 and 0.74 in the Pistacia and placebo groups, respectively. Regarding pain, the effect size of the intervention and placebo groups were 3.90 and 0.99, respectively. In addition, regarding function, the effect size of the intervention and the placebo groups were 4.33 and 1.17, respectively. Therefore, it seems that topical P. atlantica is significantly better than the placebo in the old patients with knee osteoarthritis.

2019-04-03·Journal of the American College of Nutrition4区 · 医学

Effects ofPistacia atlanticaon Oxidative Stress Markers and Antioxidant Enzymes Expression in Diabetic Rats

4区 · 医学

Article

作者: Sarabi, Mostafa Moradi ; Veiskarami, Saeid ; Bagheri, Shahrokh ; Ahmadvand, Hassan ; Khosravi, Peyman ; Keshvari, Mahtab ; Khorramabadi, Reza Mohammadrezaei

INTRODUCTIONDiabetes mellitus (DM) affects many patients all over the world. It involves different parts of the body, such as brain, eyes, kidneys, vessels, and so on. The lack of balance between free radicals and antioxidants is a possible mechanism involved in the pathogenesis of diabetes. Antioxidant treatment, especially natural forms, can be a beneficial solution. Therefore, we evaluated the effects of Pistacia atlantica oleoresin (PAO) on oxidative stress markers and antioxidant enzymes expression in diabetic rats.METHODFifty adult male Wistar rats were allotted randomly into five groups as follow: control group, diabetic control group, glibenclamide control group, diabetic glibenclamide group, diabetic treated group with 200 mg/kg PAO. Then PAO was prepared and analyzed by gas chromatography/mass spectroscopy (GC/MS). LD50 was also estimated for essential oil. Oxidative stress markers and antioxidant enzyme including malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were also measured. The expression of GPx, CAT, and SOD genes was investigated using real-time polymerase chain reaction (PCR).RESULTSThe main constituents of essential oil gum were beta-pinene (29.38%), followed by alpha-pinene (18.15%), myrcene (7.36%), trans-pinocarveol (7.15%), and camphene (4.12%). Diabetes induced an increased level of MDA (69.92 ± 3.92 vs. 43.76 ± 3.73) and decreased levels of GSH (2.57 ± 0.40 vs. 7.05 ± 1.59), GPx (11.66 ± 2.2 vs. 16.38 ± 2.1), CAT (12.17 ± 3.38 vs. 18.7 ± 2.66), and SOD (0.78 ± 0.67 vs. 2.41 ± 0.46). In contrast, PAO treatment significantly decreased MDA (54.59 ± 12.54 vs. 69.92 ± 3.92) and increased GSH (4.5 ± 0.89 vs. 2.57 ± 0.40), GPx (25.86 ± 5.37 vs. 11.66 ± 2.2), CAT (22.69 ± 0.36 vs. 12.17 ± 3.38), and SOD (3.65 ± 1.08 vs. 0.78 ± 0.67) (p < 0.05). Moreover, our results indicated that both GPx and CAT mRNA levels significantly increased approximately 4.46 and 6.23 times in rats fed with 200 mg/kg of PAO, more than that of the healthy control group, respectively (p < 0.01 and p < 0.001, respectively). Also, the average expression level of SOD was also significantly 1.57 higher in rats fed with 200 mg/kg of PAO in comparison to the diabetic control group (p < 0.05).CONCLUSIONThe results indicated that PAO could be propose as an agent that protects the body against diseases that are associated with oxidative stress.

2018-12-02·Natural Product Research3区 · 化学

Chemical and biomolecular analyses to discriminate three taxa of Pistacia genus from Sardinia Island (Italy) and their antifungal activity

3区 · 化学

Article

作者: Caboni, Pierluigi ; Marengo, Arianna ; Falconieri, Danilo ; Gonçalves, Maria José ; Piras, Alessandra ; Maxia, Andrea ; Foddis, Caterina ; Porcedda, Silvia ; Salgueiro, Lígia ; Cortis, Pierluigi ; Loi, Claudia

This work reports the results and the comparison concerning the chemical and biomolecular analyses and the antifungal activity of three wild Pistacia species (Anacardiaceae) from Sardinia. Volatile oils from leaves and twigs of Pistacia x saportae, Pistacia lentiscus and Pistacia terebinthus were characterised using GC-FID and GC-MS techniques and tested against some fungal strains. Two DNA nuclear regions (ITS and 5S-rRNA-NTS) were amplified through PCR technique and sequenced. The three **Pistacia have similar chemical profile, although there are some important quantitative differences. The analysis of ITS and 5S-rRNA-NTS regions, reveals a species-specific nucleotide variation among the three **taxa. This method could emerge as a powerful tool for the species identification, especially because the discrimination of these three **taxa appears difficult for non-expert botanists. Concerning the antifungal activity, P. lentiscus and P. x saportae show the highest activity against Cryptococcus neoformans, with a MIC value of 0.32 μL/mL.

100 项与大西洋黄连木提取物相关的药物交易

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