The purpose of the study is to evaluate whether the novel anti-cancer drug OXY111A is safe and tolerated in patients with primary and secondary hepato-pancreato-biliary and gastrointestinal neoplasia as measured by exploring the maximum tolerated dose (MTD). At level of MTD, additional patients will be included aimed for assessing the efficacy profile in these neoplasia entities.

开始日期2014-02-01

申办/合作机构

University of Zurich

100 项与 Myoinositol Trispyrophosphate 相关的临床结果

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100 项与 Myoinositol Trispyrophosphate 相关的转化医学

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100 项与 Myoinositol Trispyrophosphate 相关的专利（医药）

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项与 Myoinositol Trispyrophosphate 相关的文献（医药）

2025-04-01·iMeta

New insights into genome assembly at the chromosome‐level of Prunus tomentosa in evolution and cold tolerance

Article

作者: Wang, Shiping ; Zhang, Qijing ; Xu, Yan ; Song, Xiaoming ; Zhang, Caixi ; Manzoor, Muhammad Aamir ; Dong, Yang ; Liu, Moyang ; Zhang, Xinyu ; Fu, Yanhong ; Lv, Zhengxin ; Li, Chengwei ; Jiu, Songtao ; Shen, Shaoqin ; Liu, Ruie ; Liu, Xunju ; Chen, Baozheng

This study assembled a high-quality chromosome-level genome of Prunus tomentosa, offering a vital resource for elucidating its genetic architecture, evolutionary relationships, and facilitating genome-assisted breeding efforts. Multi-omics integration revealed PtIMP3 and PtMIOX1L as key factors in cold tolerance of P. tomentosa. PtIMP3 drives the conversion of glucose-6-phosphate to myo-inositol, while PtMIOX1L catalyzes myo-inositol to d-glucuronic acid. Specifically, the high expression abundance of PtIMP3 and low expression abundance of PtMIOX1L resulted in high endogenous inositol levels in P. tomentosa. The application of myo-inositol enhanced the cold tolerance of cherry rootstocks by modulating reactive oxygen species concentrations and maintaining a stable relative water content. This finding supports the superior performance of P. tomentosa in adapting to extreme low-temperatures environmental conditions. These insights advance strategies for improving cold tolerance in horticultural crops, bridging fundamental research with practical applications in developing climate-resilient crops.

2025-04-01·Drug Testing and Analysis

Doping control analysis of myo‐inositol trispyrophosphate and 10 bisphosphonates in equine plasma by ion chromatography–mass spectrometry and its application to clodronic acid horse administration

Article

作者: So, Yat‐Ming ; Wong, Celia Oi Ling ; Yuen, Bruce Pui‐Nam ; Kwok, Wai Him ; Wong, April Sum Yee ; Kong, Fred Ka‐Wai ; Wan, Terence See Ming ; Ho, Emmie Ngai‐Man ; Brooks, Lydia

Abstract:

Bisphosphonates and myo‐inositol trispyrophosphate (ITPP) are two classes of difficult‐to‐detect polar drugs that are prohibited under the rules of racing. ITPP is a drug capable of increasing the amount of oxygen in hypoxic tissues, and studies have shown that administration of ITPP increases the maximal exercise capacity in mice. The properties of ITPP make it an ideal candidate as a doping agent to enhance performance in racehorses. In recent years, ITPP had indeed been detected in racehorses and confiscated items. As for bisphosphonates, it is especially critical to control their use as since February 2019, the International Agreement on Breeding, Racing and Wagering (IABRW) by the International Federation of Horseracing Authorities (IFHA) had identified specific conditions on which bisphosphonates should not be administered to a racehorse. A recent review of literature shows that there is yet a simultaneous screening method for detecting ITPP and bisphosphonates in equine samples. This paper describes an efficient ion chromatography high‐resolution mass spectrometry (IC‐HRMS) method for the simultaneous detection of ITPP and 10 bisphosphonates at sub‐parts‐per‐billion (ppb) to low‐ppb levels in equine plasma after solid‐phase extraction (SPE) and its application to an administration study of clodronic acid in horses.

2025-01-16·JOURNAL OF PHYSICAL CHEMISTRY B

Cooperative Dynamics and Hydration of Aqueous D-Mannitol and myo-Inositol

Article

作者: Korus, Paweł ; Buchner, Richard ; Płowaś-Korus, Iwona

The cooperative dynamics and hydration of D-mannitol and myo-inositol in aqueous solution at 25 °C were investigated by broad-band dielectric relaxation spectroscopy (DRS) for solute concentrations c < 0.9M. The recorded spectra, covering the frequency range 0.05 ≤ ν/GHz ≤ 50, can be described as a superposition of three Debye-type relaxation processes. The determined total effective hydration numbers, Z_t, as well as the effective dipole moments, μ_eff, of D-mannitol and myo-inositol do not depend on solute concentration. The Z_t values obtained for both sugar alcohols are significantly smaller than that of the previously studied xylitol. In contrast to aqueous xylitol, the dielectric spectra also showed no indication of the formation of D-mannitol or myo-inositol aggregates.

项与 Myoinositol Trispyrophosphate 相关的新闻（医药）

2024-07-30

·echemi

To Explore the Application of

In recent years,"myo inositol powder" has generated much discussion in the field of women's health. As a natural physiologically active compound, inositol can effectively maintain endocrine balance, while helping to resist the invasion of a variety of chronic diseases. This article will provide an in-depth analysis of the key role of myo inositol powder in the maintenance of women's health, and put forward corresponding guidance for use, so as to provide a solid guarantee for women's health. For women, health is undoubtedly a priceless asset. However, modern fast-paced lifestyles often expose us to a variety of health challenges, such as common diseases such as polycystic ovary syndrome (PCOS). As an endocrine disorder, PCOS not only affects women's reproductive function, but also may lead to a series of serious complications. In dealing with PCOS, the role of myo inositol powder cannot be ignored. Inositol, as a naturally occurring physiologically active substance in human body, can effectively regulate insulin metabolism, thereby improving insulin resistance and alleviating the symptoms of PCOS. A large number of studies have shown that appropriate supplementation of myo inositol powder can significantly improve the fertility of patients with PCOS while preventing the occurrence of related complications. The benefits of myo inositol powder are not limited to the treatment of PCOS, it also plays a positive role in menstrual management in women, menopausal symptoms relief, and prevention of type 2 diabetes and cardiovascular disease. Therefore, women can consider appropriate intake of myo inositol powder to add a line of defense to their health. However, relying solely on the supplement of myo inositol powder is not enough. We also need to make comprehensive adjustments in diet structure, living habits and other aspects. For example, increase the intake of dietary fiber, vitamins and minerals, reasonable control of sugar and fat intake; At the same time, maintain adequate sleep, regular rest and rest, and appropriate exercise. Only through comprehensive management, can we truly achieve the comprehensive promotion of women's health. Myo inositol powder provides a powerful support for women's health, but we should avoid viewing it as the only solution. A comprehensive health management strategy should be adopted according to the individual's specific situation. Only in this way can the majority of women truly embrace a healthy and beautiful future.

2024-07-30

·echemi

Women's Health From the Perspective of

"Myo inositol PCOS", a topic that has attracted much attention in the medical field in recent years, reveals the subtle relationship between endocrine disorders and women's health. Polycystic ovary syndrome (PCOS) is a common gynecological disorder that affects a wide range of women, from reduced fertility to a range of health problems. The discovery of "myo inositol PCOS" offers new hope for improving the condition of PCOS patients. The pathogenesis of PCOS is complex, in which the imbalance of myo inositol PCOS plays a key role. Reduced levels of inositol, a substance that occurs naturally in the body, can lead to insulin resistance, which in turn triggers or exacerbates the symptoms of PCOS. A large number of studies have confirmed that through the supplement of "myo inositol", the normal insulin response in the body can be restored, thereby improving the symptoms of irregular menstruation, acne, hirsutism and other symptoms, and improving the quality of life of patients. However, the supplementation of "myo inositol PCOS" is only the first step in treating PCOS. In order to achieve the overall improvement of women's health, we also need to pay attention to the adjustment of diet structure and lifestyle changes. It is recommended that patients increase whole grains, vegetables, fruits and other fiber-rich foods to enhance the body's ability to process sugar, while reducing the intake of sugar and saturated fat to prevent the type 2 diabetes and cardiovascular disease complicated by PCOS. In addition, maintaining adequate sleep, a regular schedule, and proper exercise can all help improve the endocrine environment and further relieve the symptoms of PCOS. It is important to note that the physique and symptoms of each PCOS patient are different, so when implementing the treatment plan, a personalized health management plan should be developed according to the specific circumstances of the individual. This may include regular medical checkups, professional nutritional counseling, and even psychological counseling to ensure that the patient is fully supported, both physically and psychologically. The discovery of "myo inositol PCOS" opens new avenues for the treatment of PCOS, but we should also recognize that comprehensive health management is the key to defeating PCOS. Only through a comprehensive and individualized treatment strategy can we help women out of the shadow of PCOS, regain their health and confidence, and embrace a better future.

2024-07-30

·echemi

On the Synergies of 'Myo Inositol and D-Chiro Inositol' In Women's Health

In recent years, myo inositol and D-chiro inositol, two physiologically active substances, have gradually become the focus of research. They have shown remarkable effects in maintaining endocrine stability and warding off chronic diseases in women. This paper will deeply discuss the synergistic effect of these two substances in the maintenance of women's health, and put forward corresponding application strategies to provide strong protection for women's health. In women's health research, "myo inositol and D-chiro inositol" are gaining prominence. As natural physiological active components in the human body, they play an indispensable role in regulating endocrine balance and preventing a variety of diseases. For women suffering from polycystic ovary syndrome (PCOS), the synergistic effect of myo inositol and D-chiro inositol is particularly critical. PCOS is a typical endocrine disorder, and these two can effectively enhance insulin sensitivity, thereby reducing the symptoms of PCOS. A large amount of clinical evidence shows that moderate supplementation of these two substances can not only improve fertility in PCOS patients, but also help prevent complications such as cardiovascular disease. In addition, "myo inositol and D-chiro inositol" also play an important role in other health problems in women. They help regulate the menstrual cycle and reduce menopausal discomfort, while also reducing the risk of type 2 diabetes. This fully proves their broad application potential in women's health management. It is worth noting that relying solely on the supplement of "myo inositol and D-chiro inositol" is not enough, and we also need to create comprehensive support for women's health from various aspects of diet and lifestyle. For example, increase the intake of dietary fiber, vitamins and minerals, moderate control of sugar and fat intake; At the same time, ensure adequate sleep, maintain a regular schedule, and carry out appropriate exercise. Only through comprehensive conditioning, can we truly achieve the comprehensive promotion of women's health. "Myo inositol and D-chiro inositol" provide a powerful complement to women's health, but we should not see it in isolation. Only through comprehensive health management, the majority of women can truly achieve a healthy and happy life.

100 项与 Myoinositol Trispyrophosphate 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	Myoinositol Trispyrophosphate	-	-

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
不孕	临床3期	-	Biosearch SA	2016-02-01
多囊卵巢综合征	临床3期	-	Biosearch SA	2016-02-01
胆管癌	临床2期	瑞士	University of Zurich	2014-02-01
结直肠癌	临床2期	瑞士	University of Zurich	2014-02-01
肝细胞癌	临床2期	瑞士	University of Zurich	2014-02-01
胰腺癌	临床2期	瑞士	University of Zurich	2014-02-01
心脏衰竭	临床1期	美国	NormOxys, Inc.	-
心脏衰竭	临床1期	-	University of Zurich	-
肿瘤	临床1期	美国	NormOxys, Inc.	-
肥胖	临床1期	-	University of Zurich	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02528526 (Pubmed \| Nat Commun) 人工标引	临床1期	肿瘤	28	Myo-inositol trispyrophosphate	憲餘鹹壓鏇構製艱餘襯(鬱築構鹽製製憲鏇餘鬱) = 32 treatment-related toxicities (mostly hypercalcemia) 夢夢壓憲願餘遞夢觸壓 (製鏇糧觸築齋襯觸鬱壓 )	积极	2021-06-21