Unexpected deaths and unplanned intensive care unit (ICU) admissions are common during hospital stay and are often preceded by warning abnormalities in patients' vital signs. These abnormalities trigger Medical Emergency Team (MET) activation and up to 15% of patients visited by the MET is admitted to the ICU with an overall hospital stay after the MET intervention of approximately 2 weeks. Phosphocreatine (PCr) is a natural energy-buffering molecule associated with signals of mortality reduction in patients with acute cardiac conditions (according to meta-analytic finding from our group) and with encouraging beneficial effects on other acute organ failures (e.g. brain). The investigators designed a multi-center, randomized, placebo-controlled trial to confirm the promising beneficial effects of PCr in hospitalized patients. The investigators expects a reduction in hospital stay (measured as an increase in days alive and out of hospital at 30 days) when PCr is added to standard treatment in patients requiring MET intervention.

开始日期2024-10-08

申办/合作机构

Università Vita-Salute San Raffaele

IRCT20230127057247N1 / CompletedN/AIIT

Effects of combined dietary supplementation of protein and creatine on outcomes and acceleration of postoperative recovery in patients with peritrochantic fracture: A double-blind interventional esoteric study

开始日期2023-03-11

申办/合作机构

Tehran University of Medical Sciences

JPRN-UMIN000049691 / CompletedIIT

Study on the effect of creatine /ergothioneine supplementation on sperm motility and in vitro fertilization - Study on the effect of creatine /ergothioneine supplementation on sperm motility and in vitro fertilization

开始日期2022-12-06

申办/合作机构-

100 项与磷酸肌酸钠相关的临床结果

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100 项与磷酸肌酸钠相关的转化医学

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100 项与磷酸肌酸钠相关的专利（医药）

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项与磷酸肌酸钠相关的文献（医药）

2024-10-01·MOLECULAR REPRODUCTION AND DEVELOPMENT

Combination of Exogenous Spermidine and Phosphocreatine Efficiently Improved the Quality and Antioxidant Capacity of Cryopreserved Boar Sperm and Reduced Apoptosis‐Like Changes

Article

作者: Guo, Qing ; Li, Yanbing ; Guo, Minghui ; Wang, Hechuan ; Li, Jingchun

ABSTRACT:

The low resistance of boar sperm to cryopreservation dictates that addition antioxidants and energetic substances to the diluent to improve sperm quality is necessary. This study evaluated the effect of spermidine and phosphocreatine in combination on the quality, antioxidant capacity, and antiapoptotic‐like changes capacity of cryopreserved boar sperm based on previous reports. The results showed that the combined application of spermidine and phosphocreatine significantly enhanced the motility, average path velocity, straight‐line velocity, curvilinear velocity, beat cross frequency, acrosome integrity, plasma membrane integrity, mitochondrial activity, and DNA integrity compared with the control group (p < 0.05). In addition, the combined application of spermidine and phosphocreatine significantly enhanced the total antioxidant capacity, superoxide dismutase activity, glutathione peroxidase activity, and catalase activity while significantly decreasing malondialdehyde content and hydrogen peroxide content (p < 0.05). Western Blot analysis further showed that spermidine and phosphocreatine significantly decreased the expression of CASP3 and BAX and significantly enhanced the expression of BCL2 (p < 0.05); therefore, the combination of spermidine and phosphocreatine has potentially positive implications for improving the quality of cryopreserved boar sperm.

2024-09-01·CHEMICO-BIOLOGICAL INTERACTIONS

Phosphocreatine attenuates doxorubicin-induced nephrotoxicity through inhibition of apoptosis, and restore mitochondrial function via activation of Nrf2 and PGC-1α pathways

Article

作者: Alyafeai, Eman ; Aldahmash, Waleed ; Tang, Zeyao ; Almaamari, Ahmed ; Mahyoub, Mueataz A ; Almoiliqy, Marwan ; Qaed, Eskandar ; Sultan, Marwa

Doxorubicin (DOX), a chemotherapy drug widely recognized for its efficacy in cancer treatment, unfortunately, has significant nephrotoxic effects leading to kidney damage. This study explores the nephroprotective potential of Phosphocreatine (PCr) in rats, specifically examining its influence on Nrf2 (Nuclear factor erythroid 2-related factor 2) and PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) pathways, its role in apoptosis inhibition, and effectiveness in preserving mitochondrial function. The research employed in vivo experiments in rats, focusing on PCr's capacity to protect renal function against doxorubicin-induced damage. The study entailed evaluating Nrf2 and PGC-1α pathway activation, apoptosis rates, and mitochondrial health in renal tissues. A significant aspect of this research was the use of high-resolution respirometry (HRR) to assess the function of isolated kidney mitochondria, providing in-depth insights into mitochondrial bioenergetics and respiratory efficiency under the influence of PCr and doxorubicin. Results demonstrated that PCr treatment significantly enhanced the activation of Nrf2 and PGC-1α pathways, reduced apoptosis, and preserved mitochondrial structure in doxorubicin-affected kidneys. Observations included upregulated expression of Nrf2 and PGC-1α target genes, stabilization of mitochondrial membranes, and a notable improvement in cellular antioxidant defense, evidenced by the activities of enzymes like superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA) This study positions phosphocreatine as a promising agent in mitigating doxorubicin-induced kidney damage in rats. The findings, particularly the insights from HRR on isolated kidney mitochondria, highlight PCr's potential in enhancing mitochondrial function and reducing nephrotoxic side effects of chemotherapy. These encouraging results pave the way for further research into PCr's applications in cancer treatment, aiming to improve patient outcomes by managing chemotherapy-related renal injuries.

2024-06-01·Pediatric cardiology

Clinical Effect Analysis of Different Doses of Creatine Phosphate Sodium Combined with Immunoglobulin in the Treatment of Pediatric Viral Myocarditis

Article

作者: Xing, Shuhua ; Li, Lu ; Deng, Jiegang ; Wang, Meng

The purpose of this paper was to unravel the clinical effect analysis of different doses of creatine phosphate sodium (CPS) combined with immunoglobulin in the treatment of pediatric viral myocarditis (VMC). One hundred and twenty children with VMC were recruited and randomized into three groups (40 patients each). Group I received 1.0 g of CPS dissolved in 100 mL of 5% glucose injection intravenously 1 time/day; group II received 1.25 g of CPS dissolved in 125 mL of 5% glucose injection intravenously 1 time/day; group III received 1.5 g of CPS dissolved in 150 mL of 5% glucose injection intravenously 1 time/day; then all three groups were treated with combined use of immunoglobulin (300-400 mg/day) intravenously once a day; and all three groups were treated for 14 days. The clinical efficacy, cardiac function, serum inflammatory factor levels, immune function, and the occurrence of drug toxicity and adverse effects of the children in the three groups were compared after 14 days of treatment. All three groups achieved better therapeutic effects after treatment, in which the effective rate of the Group II and Group III was notably higher versus the Group I. Lower levels of cTnI, CK-MB, LDH, AST, IL-18, IL-6, IFN-γ, and LVEDD and higher CD3⁺, CD4⁺, and CD4⁺/CD8⁺, FS, and LVEF values were noted in the Group II and Group III versus the Group I, and the results were more pronounced in the high-dose group. The liver and kidney functions of the children in the three groups before and after treatment did not show any significant changes and the incidence of adverse reactions during the treatment period was low in all three groups. Children with VMC can be treated with high-dose CPS in combination with immunoglobulin, which can improve their cardiac function and immune function and reduce the inflammatory response with good overall therapeutic efficacy and fewer adverse effects.

项与磷酸肌酸钠相关的新闻（医药）

2024-03-26

·药闻康策

考核金额占比，基药迎利好！

☝ 点击上方一键预约 ☝ 最新最热的医药健康新闻政策近日，国家卫健委公布了2024年版的二级公立医院和三级公立医院绩效考核目标，共28个考核指标，这其中和药品使用直接相关的包括：抗菌药使用强度、基本药物使用、集采药品使用、重点监控药品收入占比、重点监控耗材收入占比等。除了集采药品、基本药物使用要求逐步提高外，其他都要逐步降低。笔者一直认为药品使用各种相关考核指标中，只有金额占比是最为实实在在的考核指标，能够给药企带来最切实的变化。今年，基本药物的考核全面升级，在医院基药使用考核中，金额占比开始纳入考核，基本药物迎来全面利好。重点监控上，本次仍考核第一批纳入重点监控目录的品种，新增入目录23个品种逃过一劫。国家集采中选药品使用上，二级医院考核采购金额，让国采中选药品在二级医院迎来更多利好，国采中选药品可以趁势在二级医院做推广。重点监控药品：只监控第一批目录品种重点监控药品和重点监控耗材使用占比是二级和三级公立医院绩效考核指标，对于新增进第二批重点监控目录的品种来说，今年逃过了一劫。国家卫健委二级医院和三级医院考核细则中，都明确今年关于重点监控用药考核仍是考核第一批重点监控药品。（下面两图分别为三级医院和二级医院考核指标的考核说明）2023年1月13日，国家卫健委公布第二批重点监控药品名单，共30个品种被纳入。据目录公布时政策要求，未纳入第二批《目录》即调出目录品种，应当持续监控至少满1年后可不再监控，以促进临床合理用药水平持续提高。而仍持续保留在重点监控目录内的，要按照要求加强重点监控。对于所有品种，各地要以规范临床用药行为、促进合理用药为工作目标，对纳入本目录的药品制定完善临床应用指南，明确临床应用的条件和原则，加强合理用药监管。有13个品种被调整出重点监控目录，这些品种为脑苷肌肽、小牛血清去蛋白、复合辅酶、丹参川穹嗪、转化糖电解质、鼠神经生长因子、胸腺五肽、核糖核酸II、曲克芦丁脑蛋白水解物、核糖核酸、长春西汀、马来酸桂哌齐特、小牛血去蛋白提取物。7个品种仍保留在目录内：依达拉奉、神经节苷脂、骨肽、脑蛋白水解物、奥拉西坦、前列地尔、磷酸肌酸钠。23个品种为新增加品种，这些品种为：奥美拉唑、人血白蛋白、头孢哌酮舒巴坦、银杏叶提取物、泮托拉唑、复方氨基酸、地佐辛、倍他司汀、布地奈德、烟酰胺、头孢他啶、哌拉西林他唑巴坦、艾司奥美拉唑、吡拉西坦、左氧氟沙星、法莫替丁、雷贝拉唑、罂粟碱、烟酸、乙酰谷酰胺、兰索拉唑、美罗培南、头孢噻肟。公立医院绩效考核一般是去年一些指标进行考核和回顾，国家卫健委要求已经被调出仍保留一年监控期，继续考核被调出的13个品种属于政策范围内，但去年新增加的23个品种未被纳入考核指标仍是让人感到意外。三级医院：基药迎来更多利好金额占比开始纳入基药考核中，基本药物正迎来全面利好。其一，我们看到在考核指标中，无论是二级医院还是三级医院，都考核到基药的金额占比。其中二级医院考核的核心指标是基本药物采购金额占比，即年度内医院基本药物采购金额数占医院同期采购药物金额总数的比例。而三级医院延伸考核指标里面，考核的是基本药物配备使用金额占比，考核进一步升级了，这个比例对于三级公立医院约束力将更强，因为不仅仅是采购，还考核到使用金额，这个考核指标对于提升基本药物在三级医院的使用刺激作用将更为明显。其次，是从考核指标上，无论是二级医院还是三级医院，都有不少考核指标与基本药物使用相关。其中，二级医院除了采购指标外，和基药相关的延伸考核指标还包括：基本药物采购品种数占比、门诊处方使用占比、住院使用占比等，预计是为了防止出现基本药物使用集中于一些高价基药上。三级医院考核上更为细化，除了上面提及基本药物采购品种占比及其延伸考核指标外，核心指标还包括基药门诊使用占比、住院患者使用率等2个指标。每个指标后面都有一个延伸指标，由此三级医院基药方面考核达到了6个。二级医院：集采中选药品使用更有利好金额考核指标同样出现在了二级医院关于国家集采中选药品考核中。在这一指标中，二级医院考核的采购金额占比，虽然不是最为理想的使用金额占比，但没有采购哪来的使用？在这一考核指标指引下，国采中选药品在二级医院将迎来更多利好，国采中选厂家也可以借助这一政策优势更好推广国采中选药品。附：第一批重点监控品种名单(来源:趣学术）药闻康策新媒体矩阵微信公众号点击下方一键关注【免责声明】1.“药闻康策”部分文章信息来源于网络转载是出于传递更多信息之目的，并不意味着赞同其观点或证实其内容的真实性。如对内容有疑议，请及时与我司联系。2.“药闻康策”致力于提供合理、准确、完整的资讯信息，但不保证信息的合理性、准确性和完整性，且不对因信息的不合理、不准确或遗漏导致的任何损失或损害承担责任。3.“药闻康策”所有信息仅供参考，不做任何商业交易或医疗服务的根据，如自行使用“药闻康策”内容发生偏差，我司不承担任何责任，包括但不限于法律责任，赔偿责任。欢迎转发分享、点赞、点在看

带量采购核酸药物

2023-09-11

·药闻康策

20款重点监控品种销售逆势上涨！

☝ 点击上方一键预约 ☝ 最新最热的医药健康新闻政策重点监控药品的合理规范，细化监控正式拉开帷幕，这么大的市场规模将何去何从？近千亿会下滑缩为百亿吗？近日，国家卫健委主管的《中国药房》杂志刊出了《国家重点监控药品合理用药管理规范》，明确了重点监控品种在医院管理的规范，对重点监控药品进行了分级管理，超常预警制度建立后，不合理用药的产品将面临警示、限制采购、暂停采购、停止采购等多种处罚措施。这是国家首次出台第二批重点监控目录的具体实施规则，意味着过度诊疗和临床药品滥用的监管愈发趋严。今年年初，第二批重点监控目录的才刚公布，如今专家共识和规范指导原则就顺应出台到位。与第一批重点监控目录的以辅助用药为主的不同，第二批的品种大多是疗效明确、临床必需的品种。第一批有7个品种被保留在第二批重点监控目录中，包括有脑蛋白水解物、依达拉奉注射剂、奧拉西坦、神经节苷脂、骨肽、前列地尔和磷酸肌酸钠。因辅助用药概念引发大地震的第一批重点监控目录，后又受到踢出医保和纳入集采的双重暴击，大部分品种的规模仅有此前销售峰值的十分之一，列入目录后该产品几乎被“判死刑”。如今8个多月过去了，第二批重点监控目录主要是疗效明确、临床必需品种的销售走势如何？规范指导原则政策的打击会堪比国家集采吗？01千亿规模，何去何从？相比第一批多了10个品种，第二批国家重点监控目录涉及到30个品种，有23个新入围的知名药品，如人血白蛋白、美罗培南、奥美拉唑、哌拉西林他唑巴坦、复方氨基酸、布地奈德、地佐辛等。按治疗领域划分，有神经系统用药，胃肠道的质子泵抑制剂和抑制胃酸药物、全身抗菌药物、阿片类镇痛药和呼吸系统用药等。第二批国家重点监控目录品种的院内市场接近千亿的庞大规模。中康CHIS开思数据库显示，人血白蛋白是这批品种中院内规模最大的品种，这个从人的血浆提取出来的血液制品临床应用较广，但价格较贵，虽然已经进了国家医保乙类，但报销范围却有点窄。2022年院内的人血白蛋白排名前六厂商均是外企，且他们的院内份额均拥有超过10亿。来源： CHIS数据库，中康产业研究院整理纳入第二批重点监控的所有药品都已经历过省级集采的“洗礼”，过半数品种已经被纳入国家集采。7个品种被再次保留在第二批重点监控目录的品种，经过3年多的“风暴”后，院内销售额排名靠后，规模已经下滑了一个数量级。02重点监控下却逆势上涨！重点监控目录不仅仅是约束的“紧箍咒”，也是合理用药的引导者。中康CHIS开思数据库显示，距离第二批重点监控公开的半年后，并不是所有品种都和第一批殊途同归。2023年上半年院内的销售额下滑较为严重的是头孢哌酮、乙酰谷酰胺、奥美拉唑和美罗培南，同比下降超过50%。来源： CHIS数据库，中康产业研究院整理值得注意的是，多数重点监控品种却“逆势上涨”。中康CHIS开思数据库显示，品种同比增长较为明显的是烟酸、头孢噻肟和布地奈德，2023年上半年院内的销售额的同比增长率均超过50%。30个品种里面，20个品种在2023年上半年的表现是正向增长的，12个规模过10亿，人血白蛋白在上半年的院内规模就已经过百亿了，增速相当可观。国家重点监控目录除了保障患者安全和疗效之外，另一个重要目的在于减少医保基金和患者的不必要支出，随着重点监控工作演进，在指导原则和规范之下，药品的临床应用也会趋于越来越规范和理性。纳入国家重点监控目录的药品并不意味着会被严格限制使用，好药用在“刀刃”上，临床上更注意合适的剂量和量程，避免过度使用，减少副作用的发生。(来源:新康界）药闻康策新媒体矩阵微信公众号点击下方一键关注【免责声明】1.“药闻康策”部分文章信息来源于网络转载是出于传递更多信息之目的，并不意味着赞同其观点或证实其内容的真实性。如对内容有疑议，请及时与我司联系。2.“药闻康策”致力于提供合理、准确、完整的资讯信息，但不保证信息的合理性、准确性和完整性，且不对因信息的不合理、不准确或遗漏导致的任何损失或损害承担责任。3.“药闻康策”所有信息仅供参考，不做任何商业交易或医疗服务的根据，如自行使用“药闻康策”内容发生偏差，我司不承担任何责任，包括但不限于法律责任，赔偿责任。欢迎转发分享、收藏、点赞、点在看

带量采购

2023-08-04

·PRNewswire

Bizz Energy Clears Minds and Sharpens Focus

The Clean, Zero-Sugar Energy Drink Is Good For More Than Just Physical Performance. It Boosts Brain Function, Too. FORT LAUDERDALE, Fla., Aug. 4, 2023 /PRNewswire/ -- Bizz Energy is a revolutionary new zero-sugar energy drink designed to boost performance through natural ingredients without the use of harmful chemicals or additives. While this is primarily focused on physical activities, the energy supplement's ingredients can also deliver some helpful benefits for the brain. "I designed Bizz Energy to clear my mind as well as boost my physical performance," explains company founder Gavin Jacono. "Sometimes you need to do more than run faster, lift more, or stay awake longer. Sometimes you need that sharp focus that helps you deliver at work or in school." Bizz Energy helps with cognitive function through multiple natural ingredients. For instance, creatine is a safe brain and body amino acid that has been connected to short-term memory improvement when administered orally. L-citrulline has clearly demonstrated benefits for brain function, as well. L-Theanine relieves stress disorders, improves mood, and helps with sleep. Another ingredient with the potential to help with cognition is Turkesterone. While this popular supplement is currently trending in the sports and fitness world for its physical benefits, there are also suggestions that it could aid mental health by helping cope with stress and fatigue. "Including Turkesterone was a big deal for us," says Jacono. "I knew we wanted it in there, but it's a plant-based steroid, so it isn't water-soluble. We invested in extensive research and testing and were able to develop a method to solubilize Turkesterone — it's one of the most unique things about our product." From carefully selected amino acids to soluble Turkesterone, Bizz Energy is packed with natural ingredients designed to deliver a critical dose of energy when needed. The innovative combination of natural ingredients doesn't just apply to physical performance, either. It can be a game-changer when it comes to cognitive function, too, helping to sharpen the mind and create clear focus. About Bizz Energy Bizz Energy was founded by Gavin Jacono. The fitness and nutrition fanatic hails from New York City and is obsessed with boxing, weightlifting, and soccer. As an aspiring 17-year-old entrepreneur, Jacono launched Bizz Energy as a way to create the ultimate energy drink he had always wanted to fuel his athletic pursuits. Along with a potent dose of caffeine, the Bizz Energy formula taps into a unique form of soluble Turkesterone. It is delicious, clean, and effective. Learn more at bizzenergy.com. Media Contact: Gavin Jacono 516-637-8701 [email protected] SOURCE Bizz Energy

100 项与磷酸肌酸钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	C01EB	DB13191

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心血管疾病	中国	Alfa Wassermann SpA	2000-08-04

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01502813 (CTgov)	N/A	认知	40	Creatine+Citicoline, Omega-3 Fatty Acids	膚築顧壓糧觸襯製鹽艱(鹽範廠窪積蓋壓艱鹽簾) = 衊選獵製鹽築獵築淵網簾衊窪醖糧廠簾願廠網 (淵築願獵壓繭遞遞衊艱, 糧鹹艱鹽願積鹽積夢積 ~ 夢膚鬱簾餘壓觸窪簾蓋) 更多	-	2021-04-22
NCT00449865 (NET-PD LS-1, CTgov)	临床3期	帕金森病	1,741	placebo (Placebo)	網鏇顧構簾衊選鏇鹽願(選製鑰餘觸窪膚淵範醖) = 窪選憲構膚壓夢餘繭齋衊鏇網遞願廠襯顧衊積 (鏇襯簾網繭艱網壓願餘, 鹹鹽鹹遞願蓋鹹鑰廠餘 ~ 夢築廠淵衊構網膚鹽夢) 更多	-	2015-04-02
NCT00449865 (NET-PD LS-1, CTgov)	临床3期	帕金森病	1,741	creatine (Creatine)	網鏇顧構簾衊選鏇鹽願(選製鑰餘觸窪膚淵範醖) = 遞膚鑰餘鬱構齋淵窪構衊鏇網遞願廠襯顧衊積 (鏇襯簾網繭艱網壓願餘, 觸鏇齋淵築淵窪構膚製 ~ 製鏇餘鏇觸構膚選網製) 更多	-	2015-04-02