Study on the effect of creatine /ergothioneine supplementation on sperm motility and in vitro fertilization - Study on the effect of creatine /ergothioneine supplementation on sperm motility and in vitro fertilization

开始日期2022-12-06

申办/合作机构-

NCT04665804 / CompletedN/AIIT

Effects of Creatine Supplementation as Compared to Glucosamine/Chondroitin Sulfate Supplementation in Addition to Exercise and Physical Therapy in the Management of Knee Osteoarthritis.

Osteoarthritis (OA) is one of the most common joint disorders, affecting not only the joints but also the surrounding muscles, which become weak. Resistance exercise reduces pain and improves function in patients with OA of the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used by patients with OA to reduce pain and thereby maintain the ability to perform daily activities. However, there is accumulating evidence for a negative effect of NSAIDs, thus many patients with OA are treated with dietary supplementations such as glucosamine and chondroitin sulfate, and some studies show a beneficial effects on cartilage and pain. However, their effect on OA symptoms and cartilage remains controversial. On the other hand creatine supplementation has also been observed to show promising effects when combined with resistance training exercise in the elderly, but the evidence is limited in terms of knee osteoarthritis. For this reason the purpose of this study is to determine the effects of creatine supplementation as compared to glucosamine/chondroitin sulfate in the management of knee osteoarthritis when combined with resistance training exercise.

开始日期2020-06-10

申办/合作机构

Foundation University Islamabad

RBR-9832jt / Not yet recruitingN/AIIT

Thermogenic Adaptation in Patients with Polycystic Ovarian Syndrome with Metabolic Syndrome Supplemented by Chronology with L-Arginine, Caffeine or Creatine and Training Resisted Exercise - Randomized Study

开始日期2019-02-01

申办/合作机构

Federal University of Mato Grosso

100 项与磷酸肌酸钠相关的临床结果

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100 项与磷酸肌酸钠相关的转化医学

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100 项与磷酸肌酸钠相关的专利（医药）

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385

项与磷酸肌酸钠相关的文献（医药）

2024-01-17·Journal of molecular neuroscience : MN

Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway.

Article

作者: Eskandar Qaed ; Eman Alyafeai ; Ahmed Al-Maamari ; Mohamed Y Zaky ; Marwan Almoiliqy ; Bandar Al-Hamyari ; Abdullah Qaid ; Saeed Yafei ; Waleed Aldahmash ; Mueataz A Mahyoub ; Fuhan Wang ; Le Kang ; Zeyao Tang ; Jianbin Zhang

Diabetic retinopathy (DR) stands as a prevalent complication of diabetes mellitus, causing damage to the delicate retinal capillaries and potentially leading to visual impairment. While the exact underlying cause of DR remains elusive, compelling research suggests that mitochondrial energy deficiency and the excessive generation of reactive oxygen species (ROS) play pivotal roles in its pathogenesis. Recognizing that controlling hyperglycemia alone fails to reverse the defects in retinal mitochondria induced by diabetes, current strategies seek to restore mitochondrial function as a means of safeguarding against DR. To address this pressing issue, a comprehensive study was undertaken to explore the potential of phosphocreatine (PCr) in bolstering mitochondrial bioenergetics and providing protection against DR via modulation of the JAK2/STAT3 signaling pathway. Employing rat mitochondria and RGC-5 cells, the investigation meticulously assessed the impact of PCr on ROS production, mitochondrial membrane potential, as well as the expression of crucial apoptotic and JAK2/STAT3 signaling pathway proteins, utilizing cutting-edge techniques such as high-resolution respirometry and western blotting. The remarkable outcomes revealed that PCr exerts a profound protective influence against DR by enhancing mitochondrial function and alleviating diabetes-associated symptoms and biochemical markers. Notably, PCr administration resulted in an upregulation of antiapoptotic proteins, concomitant with a downregulation of proapoptotic proteins and the JAK2/STAT3 signaling pathway. These significant findings firmly establish PCr as a potential therapeutic avenue for combating diabetic retinopathy. By augmenting mitochondrial function and exerting antiapoptotic effects via the JAK2/STAT3 signaling pathway, PCr demonstrates promising efficacy both in vivo and in vitro, particularly in counteracting the oxidative stress engendered by hyperglycemia. In summary, our study sheds light on the potential of PCr as an innovative therapeutic strategy for diabetic retinopathy. By bolstering mitochondrial function and exerting protective effects via the modulation of the JAK2/STAT3 signaling pathway, PCr holds immense promise in ameliorating the impact of DR in the face of oxidative stress induced by hyperglycemia.

2023-10-13·The American journal of case reports

Improved Surgical Outcomes in Adults with Congenital Heart Disease and Decompensated Heart Failure: The Role of Perioperative Medical Optimization.

Article

作者: Anton Minaev ; Vladimir Podzolkov ; Timur Danilov ; Mikhail Chiaureli ; Bupe Mumba Mwela ; Vera Dontsova

BACKGROUND Decompensated heart failure (HF) is recognized as a significant prognostic factor for unfavorable outcomes in both the general population and adults with congenital heart diseases (ACHD). Among ACHD patients, those with advanced heart failure may be candidates for heart transplantation. However, in ACHD patients requiring heart surgery, even with reduced ejection fraction, the administration of appropriate medications can result in improved circulatory parameters, functional class, and surgical outcomes. CASE REPORT We present 5 patients who exhibited indications for open-heart surgery, advanced heart failure (HF) accompanied by congestion, and significant physical activity limitations or symptoms at rest (NYHA class III-IV). Among the patients, 40% were male, with a mean age of 47.4 years (ranging from 32 to 62 years). Three patients displayed reduced systemic ventricular ejection fraction, while 4 patients experienced arrhythmia. Congenital heart diseases (CHD) observed in the patients included repaired double-outlet right ventricle, congenitally corrected transposition of the great arteries, repaired tetralogy of Fallot, partial anomalous right pulmonary venous return, and atrial septal defect. Comprehensive heart failure medications were administered, including an angiotensin receptor neprilysin inhibitor, levosimendan, beta-blockers, phosphocreatine, and diuretics. The preoperative period ranged from 8 days to 2 months. Notably, significant clinical and hemodynamic improvements were observed in all cases, and all open-heart surgeries were successfully completed. CONCLUSIONS Advanced and decompensated HF has a high impact on surgical outcomes. Preoperative care with prescribed medical management for ACHD patients is possible and provides good early and mid-term postoperative results.

2023-07-08·Brain research bulletin

Intranasal Creatine Administration Increases Brain Creatine Level and Improves Barnes Maze Performance in Rats.

Article

作者: Kaiqing Chen ; Xiaoping Hu

While skeletal muscle creatine levels can be enhanced by exogenous creatine supplementation, the elevation of brain creatine levels with oral creatine administration remains a challenge due to a lack of effective transportation of creatine through the blood-brain barrier. Intranasal administration can bypass the blood-brain barrier and deliver drugs directly to the brain. The purpose of this study was to assess the effect of intranasal administration of creatine on brain creatine level and cognitive performance. Rats were randomly assigned into three groups intranasal administration group, oral administration group, and control group. The intranasal group exhibited fewer errors and shorter primary latency compared to the control and oral groups, respectively, during the acquisition phase of the Barnes maze. The intranasal group spent a higher percentage of time in the target quadrant during the probe trial compared to the control group. Biochemical measurements showed that the concentration of creatine in the olfactory bulbs, medial prefrontal cortex, and hippocampus of the rats in the intranasal group was higher than in the oral, and control groups. These results indicate that intranasal administration of creatine hydrochloride increases the creatine level in the rat's brain's and improves their performance in the Barnes maze.

项与磷酸肌酸钠相关的新闻（医药）

2024-03-26

·药闻康策

考核金额占比，基药迎利好！

☝ 点击上方一键预约 ☝ 最新最热的医药健康新闻政策近日，国家卫健委公布了2024年版的二级公立医院和三级公立医院绩效考核目标，共28个考核指标，这其中和药品使用直接相关的包括：抗菌药使用强度、基本药物使用、集采药品使用、重点监控药品收入占比、重点监控耗材收入占比等。除了集采药品、基本药物使用要求逐步提高外，其他都要逐步降低。笔者一直认为药品使用各种相关考核指标中，只有金额占比是最为实实在在的考核指标，能够给药企带来最切实的变化。今年，基本药物的考核全面升级，在医院基药使用考核中，金额占比开始纳入考核，基本药物迎来全面利好。重点监控上，本次仍考核第一批纳入重点监控目录的品种，新增入目录23个品种逃过一劫。国家集采中选药品使用上，二级医院考核采购金额，让国采中选药品在二级医院迎来更多利好，国采中选药品可以趁势在二级医院做推广。重点监控药品：只监控第一批目录品种重点监控药品和重点监控耗材使用占比是二级和三级公立医院绩效考核指标，对于新增进第二批重点监控目录的品种来说，今年逃过了一劫。国家卫健委二级医院和三级医院考核细则中，都明确今年关于重点监控用药考核仍是考核第一批重点监控药品。（下面两图分别为三级医院和二级医院考核指标的考核说明）2023年1月13日，国家卫健委公布第二批重点监控药品名单，共30个品种被纳入。据目录公布时政策要求，未纳入第二批《目录》即调出目录品种，应当持续监控至少满1年后可不再监控，以促进临床合理用药水平持续提高。而仍持续保留在重点监控目录内的，要按照要求加强重点监控。对于所有品种，各地要以规范临床用药行为、促进合理用药为工作目标，对纳入本目录的药品制定完善临床应用指南，明确临床应用的条件和原则，加强合理用药监管。有13个品种被调整出重点监控目录，这些品种为脑苷肌肽、小牛血清去蛋白、复合辅酶、丹参川穹嗪、转化糖电解质、鼠神经生长因子、胸腺五肽、核糖核酸II、曲克芦丁脑蛋白水解物、核糖核酸、长春西汀、马来酸桂哌齐特、小牛血去蛋白提取物。7个品种仍保留在目录内：依达拉奉、神经节苷脂、骨肽、脑蛋白水解物、奥拉西坦、前列地尔、磷酸肌酸钠。23个品种为新增加品种，这些品种为：奥美拉唑、人血白蛋白、头孢哌酮舒巴坦、银杏叶提取物、泮托拉唑、复方氨基酸、地佐辛、倍他司汀、布地奈德、烟酰胺、头孢他啶、哌拉西林他唑巴坦、艾司奥美拉唑、吡拉西坦、左氧氟沙星、法莫替丁、雷贝拉唑、罂粟碱、烟酸、乙酰谷酰胺、兰索拉唑、美罗培南、头孢噻肟。公立医院绩效考核一般是去年一些指标进行考核和回顾，国家卫健委要求已经被调出仍保留一年监控期，继续考核被调出的13个品种属于政策范围内，但去年新增加的23个品种未被纳入考核指标仍是让人感到意外。三级医院：基药迎来更多利好金额占比开始纳入基药考核中，基本药物正迎来全面利好。其一，我们看到在考核指标中，无论是二级医院还是三级医院，都考核到基药的金额占比。其中二级医院考核的核心指标是基本药物采购金额占比，即年度内医院基本药物采购金额数占医院同期采购药物金额总数的比例。而三级医院延伸考核指标里面，考核的是基本药物配备使用金额占比，考核进一步升级了，这个比例对于三级公立医院约束力将更强，因为不仅仅是采购，还考核到使用金额，这个考核指标对于提升基本药物在三级医院的使用刺激作用将更为明显。其次，是从考核指标上，无论是二级医院还是三级医院，都有不少考核指标与基本药物使用相关。其中，二级医院除了采购指标外，和基药相关的延伸考核指标还包括：基本药物采购品种数占比、门诊处方使用占比、住院使用占比等，预计是为了防止出现基本药物使用集中于一些高价基药上。三级医院考核上更为细化，除了上面提及基本药物采购品种占比及其延伸考核指标外，核心指标还包括基药门诊使用占比、住院患者使用率等2个指标。每个指标后面都有一个延伸指标，由此三级医院基药方面考核达到了6个。二级医院：集采中选药品使用更有利好金额考核指标同样出现在了二级医院关于国家集采中选药品考核中。在这一指标中，二级医院考核的采购金额占比，虽然不是最为理想的使用金额占比，但没有采购哪来的使用？在这一考核指标指引下，国采中选药品在二级医院将迎来更多利好，国采中选厂家也可以借助这一政策优势更好推广国采中选药品。附：第一批重点监控品种名单(来源:趣学术）药闻康策新媒体矩阵微信公众号点击下方一键关注【免责声明】1.“药闻康策”部分文章信息来源于网络转载是出于传递更多信息之目的，并不意味着赞同其观点或证实其内容的真实性。如对内容有疑议，请及时与我司联系。2.“药闻康策”致力于提供合理、准确、完整的资讯信息，但不保证信息的合理性、准确性和完整性，且不对因信息的不合理、不准确或遗漏导致的任何损失或损害承担责任。3.“药闻康策”所有信息仅供参考，不做任何商业交易或医疗服务的根据，如自行使用“药闻康策”内容发生偏差，我司不承担任何责任，包括但不限于法律责任，赔偿责任。欢迎转发分享、点赞、点在看

带量采购核酸药物

2023-09-11

·药闻康策

20款重点监控品种销售逆势上涨！

☝ 点击上方一键预约 ☝ 最新最热的医药健康新闻政策重点监控药品的合理规范，细化监控正式拉开帷幕，这么大的市场规模将何去何从？近千亿会下滑缩为百亿吗？近日，国家卫健委主管的《中国药房》杂志刊出了《国家重点监控药品合理用药管理规范》，明确了重点监控品种在医院管理的规范，对重点监控药品进行了分级管理，超常预警制度建立后，不合理用药的产品将面临警示、限制采购、暂停采购、停止采购等多种处罚措施。这是国家首次出台第二批重点监控目录的具体实施规则，意味着过度诊疗和临床药品滥用的监管愈发趋严。今年年初，第二批重点监控目录的才刚公布，如今专家共识和规范指导原则就顺应出台到位。与第一批重点监控目录的以辅助用药为主的不同，第二批的品种大多是疗效明确、临床必需的品种。第一批有7个品种被保留在第二批重点监控目录中，包括有脑蛋白水解物、依达拉奉注射剂、奧拉西坦、神经节苷脂、骨肽、前列地尔和磷酸肌酸钠。因辅助用药概念引发大地震的第一批重点监控目录，后又受到踢出医保和纳入集采的双重暴击，大部分品种的规模仅有此前销售峰值的十分之一，列入目录后该产品几乎被“判死刑”。如今8个多月过去了，第二批重点监控目录主要是疗效明确、临床必需品种的销售走势如何？规范指导原则政策的打击会堪比国家集采吗？01千亿规模，何去何从？相比第一批多了10个品种，第二批国家重点监控目录涉及到30个品种，有23个新入围的知名药品，如人血白蛋白、美罗培南、奥美拉唑、哌拉西林他唑巴坦、复方氨基酸、布地奈德、地佐辛等。按治疗领域划分，有神经系统用药，胃肠道的质子泵抑制剂和抑制胃酸药物、全身抗菌药物、阿片类镇痛药和呼吸系统用药等。第二批国家重点监控目录品种的院内市场接近千亿的庞大规模。中康CHIS开思数据库显示，人血白蛋白是这批品种中院内规模最大的品种，这个从人的血浆提取出来的血液制品临床应用较广，但价格较贵，虽然已经进了国家医保乙类，但报销范围却有点窄。2022年院内的人血白蛋白排名前六厂商均是外企，且他们的院内份额均拥有超过10亿。来源： CHIS数据库，中康产业研究院整理纳入第二批重点监控的所有药品都已经历过省级集采的“洗礼”，过半数品种已经被纳入国家集采。7个品种被再次保留在第二批重点监控目录的品种，经过3年多的“风暴”后，院内销售额排名靠后，规模已经下滑了一个数量级。02重点监控下却逆势上涨！重点监控目录不仅仅是约束的“紧箍咒”，也是合理用药的引导者。中康CHIS开思数据库显示，距离第二批重点监控公开的半年后，并不是所有品种都和第一批殊途同归。2023年上半年院内的销售额下滑较为严重的是头孢哌酮、乙酰谷酰胺、奥美拉唑和美罗培南，同比下降超过50%。来源： CHIS数据库，中康产业研究院整理值得注意的是，多数重点监控品种却“逆势上涨”。中康CHIS开思数据库显示，品种同比增长较为明显的是烟酸、头孢噻肟和布地奈德，2023年上半年院内的销售额的同比增长率均超过50%。30个品种里面，20个品种在2023年上半年的表现是正向增长的，12个规模过10亿，人血白蛋白在上半年的院内规模就已经过百亿了，增速相当可观。国家重点监控目录除了保障患者安全和疗效之外，另一个重要目的在于减少医保基金和患者的不必要支出，随着重点监控工作演进，在指导原则和规范之下，药品的临床应用也会趋于越来越规范和理性。纳入国家重点监控目录的药品并不意味着会被严格限制使用，好药用在“刀刃”上，临床上更注意合适的剂量和量程，避免过度使用，减少副作用的发生。(来源:新康界）药闻康策新媒体矩阵微信公众号点击下方一键关注【免责声明】1.“药闻康策”部分文章信息来源于网络转载是出于传递更多信息之目的，并不意味着赞同其观点或证实其内容的真实性。如对内容有疑议，请及时与我司联系。2.“药闻康策”致力于提供合理、准确、完整的资讯信息，但不保证信息的合理性、准确性和完整性，且不对因信息的不合理、不准确或遗漏导致的任何损失或损害承担责任。3.“药闻康策”所有信息仅供参考，不做任何商业交易或医疗服务的根据，如自行使用“药闻康策”内容发生偏差，我司不承担任何责任，包括但不限于法律责任，赔偿责任。欢迎转发分享、收藏、点赞、点在看

带量采购

2023-08-04

·PRNewswire

Bizz Energy Clears Minds and Sharpens Focus

The Clean, Zero-Sugar Energy Drink Is Good For More Than Just Physical Performance. It Boosts Brain Function, Too. FORT LAUDERDALE, Fla., Aug. 4, 2023 /PRNewswire/ -- Bizz Energy is a revolutionary new zero-sugar energy drink designed to boost performance through natural ingredients without the use of harmful chemicals or additives. While this is primarily focused on physical activities, the energy supplement's ingredients can also deliver some helpful benefits for the brain. "I designed Bizz Energy to clear my mind as well as boost my physical performance," explains company founder Gavin Jacono. "Sometimes you need to do more than run faster, lift more, or stay awake longer. Sometimes you need that sharp focus that helps you deliver at work or in school." Bizz Energy helps with cognitive function through multiple natural ingredients. For instance, creatine is a safe brain and body amino acid that has been connected to short-term memory improvement when administered orally. L-citrulline has clearly demonstrated benefits for brain function, as well. L-Theanine relieves stress disorders, improves mood, and helps with sleep. Another ingredient with the potential to help with cognition is Turkesterone. While this popular supplement is currently trending in the sports and fitness world for its physical benefits, there are also suggestions that it could aid mental health by helping cope with stress and fatigue. "Including Turkesterone was a big deal for us," says Jacono. "I knew we wanted it in there, but it's a plant-based steroid, so it isn't water-soluble. We invested in extensive research and testing and were able to develop a method to solubilize Turkesterone — it's one of the most unique things about our product." From carefully selected amino acids to soluble Turkesterone, Bizz Energy is packed with natural ingredients designed to deliver a critical dose of energy when needed. The innovative combination of natural ingredients doesn't just apply to physical performance, either. It can be a game-changer when it comes to cognitive function, too, helping to sharpen the mind and create clear focus. About Bizz Energy Bizz Energy was founded by Gavin Jacono. The fitness and nutrition fanatic hails from New York City and is obsessed with boxing, weightlifting, and soccer. As an aspiring 17-year-old entrepreneur, Jacono launched Bizz Energy as a way to create the ultimate energy drink he had always wanted to fuel his athletic pursuits. Along with a potent dose of caffeine, the Bizz Energy formula taps into a unique form of soluble Turkesterone. It is delicious, clean, and effective. Learn more at bizzenergy.com. Media Contact: Gavin Jacono 516-637-8701 [email protected] SOURCE Bizz Energy

100 项与磷酸肌酸钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	C01EB	DB13191

研发状态

适应症	最高研发状态	国家/地区	公司
-	批准上市	意大利更多	-
心血管疾病	批准上市	中国更多	Alfa Wassermann SpA 更多

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01502813 (CTgov)	N/A	认知	40	Creatine+Citicoline, Omega-3 Fatty Acids	襯醖憲淵齋繭鬱壓鏇鬱(餘構餘繭衊壓醖鑰艱鏇) = 觸顧鹽製艱齋獵積壓餘顧衊網鬱築遞選選築顧 (顧範鏇襯艱窪憲蓋積鏇, 獵構餘衊淵顧廠餘簾壓 ~ 積築遞製壓網窪淵鑰膚) 更多	-	2021-04-22
NCT00449865 (CTgov)	临床3期	帕金森病	1,741	placebo (Placebo)	鑰餘範夢醖襯鹹廠餘衊(蓋鹽範鬱顧廠艱選齋積) = 積憲積築蓋窪齋壓簾醖築鏇範範蓋遞願遞鹽構 (鏇顧網範網鹽蓋簾蓋築, 膚遞艱積淵鏇夢鹽獵膚 ~ 獵簾築網夢顧糧窪蓋醖) 更多	-	2015-04-02
NCT00449865 (CTgov)	临床3期	帕金森病	1,741	creatine (Creatine)	鑰餘範夢醖襯鹹廠餘衊(蓋鹽範鬱顧廠艱選齋積) = 鏇範觸淵鬱糧壓積鹹鹽築鏇範範蓋遞願遞鹽構 (鏇顧網範網鹽蓋簾蓋築, 壓蓋糧衊艱廠積糧糧繭 ~ 廠鑰夢窪製鑰獵願簾膚) 更多	-	2015-04-02