INO-5042(INO-5042) - 药物靶点：EP4_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

EP4

作用机制

EP4拮抗剂(前列腺素EP4受体拮抗剂)

治疗领域

心血管疾病

在研适应症-

非在研适应症

静脉功能不全

原研机构

Innothera SA

在研机构-

非在研机构

Innothera SA

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C15H7NO3S

InChIKeyVJKZUTFFMNSTTD-UHFFFAOYSA-N

CAS号14782-19-5

关联

100 项与 INO-5042 相关的临床结果

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100 项与 INO-5042 相关的转化医学

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100 项与 INO-5042 相关的专利（医药）

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1

项与 INO-5042 相关的文献（医药）

2003-01-01·Biorheology

Induced changes of leukocyte slow rolling in an in flow pharmacological model of adhesion to endothelial cells.

Article

作者: Heutte, F ; Boisseau, M R ; Boutherin-Falson, O ; Renard, M ; Finet, M

BACKGROUNDRolling of leukocytes at the surface of the vascular endothelium is a prerequisite for a subsequent firm adhesion, particularly the slow rolling appearing on ELAM CD62E. Therefore, it may be considered that increasing the rolling velocities should be a precise therapeutic target in clinical situations where leukocytes accumulate, mainly venous and arterial ischaemia.METHODSHuman neutrophils were allowed to flow on endothelial HUVECs, with and without 4 hours interleukin-1alpha activation, the cells having or not been incubated with INO5042 anti-inflammatory drug. Under a mean shear-stress of 2 dyn/cm(2), rollers and stickers were identified and quantified, using a video-camera and picture analysing software.RESULTSWhen the drug had been added to endothelial cells a shift of velocities was observed towards fast speeds (from 3-5 to 7-11 microm/sec). The same results was significantly found when neutrophils, alone or along with endothelium, had been submitted to the drug, the number of stickers and rollers beeing reduced as well. Finally, such a precise pharmacological method proved efficient to detect the exact mechanism of INO5042 on white cell adhesion.

100 项与 INO-5042 相关的药物交易

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