18F-FEPPA(18F-FEPPA) - 药物靶点：TSPO_在研适应症：诊断试剂_专利_临床

概要

基本信息

药物类型

小分子化药、诊断用放射药物

别名

靶点

TSPO

作用机制

TSPO调节剂(TSPO蛋白调节剂)、PET imaging(正电子发射断层成像术增强剂)

治疗领域

其他疾病

在研适应症

诊断试剂

非在研适应症

阿尔茨海默症炎症多发性硬化症+ [1]

原研机构

University of Toronto

在研机构

University of Toronto

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C22H21FN2O3

InChIKeyHCUHRHHLUUZJEQ-VNRZBHCFSA-N

CAS号1095267-92-7

关联

4

项与 18F-FEPPA 相关的临床试验

NCT06299592 / RecruitingN/A

Comparison of Microglial Activation in Severe Asthma and Healthy Controls

The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are:
* How airway inflammation in asthma affects the brain; and,
* Whether airway inflammation in asthma is related to symptoms of depression and anxiety
Over the course of 3 visits, participants will:
* Complete questionnaires
* Complete computer tasks
* Undergo allergy skin test and breathing tests
* Give two blood samples
* Give a sputum sample
* Complete brain imaging scans
Researchers will compare results between participants with asthma, and participants who do not have asthma.

开始日期2024-03-06

申办/合作机构

University of Wisconsin Madison

[+1]

NCT02130271 / CompletedN/AIIT

PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients

The purpose of this study is to see if the spine shows areas of inflammation using a specific type of imaging (pictures).

开始日期2014-04-01

申办/合作机构

The General Hospital Corp.

NCT02095639 / TerminatedN/AIIT

Does Electroconvulsive Therapy Cause Neuroinflammation? An [18F]FEPPA Positron Emission Tomography Study in Treatment Resistant Depression

The purpose of this study is to explore whether electroconvulsive therapy (ECT) accidentally leads to a side effect of brain inflammation. Patients with treatment resistant depression who are planning to take ECT will be subsequently approached to participate in the study.

开始日期2012-08-01

申办/合作机构

Centre for Addiction & Mental Health

100 项与 18F-FEPPA 相关的临床结果

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100 项与 18F-FEPPA 相关的转化医学

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100 项与 18F-FEPPA 相关的专利（医药）

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100 项与 18F-FEPPA 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
阿尔茨海默症	临床3期	美国	-	2009-08-01
炎症	临床3期	美国	-	2009-08-01
多发性硬化症	临床3期	美国	-	2009-08-01
帕金森病	临床3期	美国	-	2009-08-01
诊断试剂	临床1期	-	University of Toronto	-