Bovine lactoferrin (University of Queensland)(Bovine lactoferrin (University of Queensland)) - 药物靶点：LTF_在研适应症：感染，炎症_专利_临床

概要

基本信息

药物类型

重组蛋白

别名-

靶点

LTF

作用机制

LTF刺激剂(乳铁蛋白刺激剂)

治疗领域

感染其他疾病

在研适应症

感染炎症

非在研适应症-

原研机构

The University of Queensland

在研机构

The University of Queensland

非在研机构-

最高研发阶段临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

12

项与 Bovine lactoferrin (University of Queensland) 相关的临床试验

ACTRN12621001511820 / Completed临床2期IIT

A randomised, double blinded, placebo controlled trial assessing the effect of bovine lactoferrin supplementation on immune cell profiles, ex-vivo response to respiratory virus Infection and systemic inflammation in healthy, older adults.

开始日期2022-08-03

申办/合作机构

The University of Newcastle

PER-064-20 / Recruiting临床2期IIT

BOVINE LACTOFERRIN FOR THE PREVENTION OF COVID-19 INFECTION IN PHYSICIANS AND NURSES IN HOSPITALS IN LIMA, PERU: A DOUBLE BLINDED RANDOMIZED CLINICAL TRIAL

开始日期2020-10-01

申办/合作机构

Universidad Peruana Cayetano Heredia

NCT04435574 / Completed临床4期IIT

Comparison of Lactoferrin vs Traditional Iron Therapy for Treatment of Iron Deficiency Anemia in School-age Children.

Anemia is a great public health problem affecting both developing and developed countries. Iron deficiency anemia represents about 50% of causes of anemia worldwide.
Lactoferrin fortified milk has a positive effect on Hb and iron status of infants.
the hypothesis of this study is "lactoferrin may have comparable efficacy to ferrous sulfate therapy with more tolerability and fewer side effects".
the research question of this study is whether oral lactoferrin is effective for treatment of iron deficiency anemia, compared to traditional ferrous sulfate therapy regarding hemoglobin rise and side effects and tolerability.

开始日期2018-09-05

申办/合作机构

Cairo University

100 项与 Bovine lactoferrin (University of Queensland) 相关的临床结果

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100 项与 Bovine lactoferrin (University of Queensland) 相关的转化医学

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100 项与 Bovine lactoferrin (University of Queensland) 相关的专利（医药）

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447

项与 Bovine lactoferrin (University of Queensland) 相关的文献（医药）

2024-12-01·Molecular Biology Reports

Correction to: Bovine lactoferrin inhibits inflammatory response and apoptosis in lipopolysaccharide-induced acute lung injury by targeting the PPAR-γ pathway

作者: Dong, Yan ; Cai, Zhigang ; Li, Yantao ; Li, Junhu ; Wang, Can

2024-12-01·Molecular Biology Reports

Bovine lactoferrin inhibits inflammatory response and apoptosis in lipopolysaccharide-induced acute lung injury by targeting the PPAR-γ pathway

Article

作者: Dong, Yan ; Cai, Zhigang ; Li, Yantao ; Li, Junhu ; Wang, Can

BACKGROUNDLactoferrin (LF) is an iron-binding multifunctional cationic glycoprotein. Previous studies have demonstrated that LF may be a potential drug for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In this study, we explored the anti-inflammatory effect and mechanism of bovine lactoferrin (bLF) in ALI using the RNA sequencing (RNA-seq) technology and transcriptome analysis.METHODS AND RESULTSBased on the differentially expressed genes (DEGs) obtained from RNA-seq of the Lung from mouse model, the bioinformatics workflow was implemented using the BGISEQ-500 platform. The protein-protein interaction (PPI) network was obtained using STRING, and the hub gene was screened using Cytoscape. To verify the results of transcriptome analysis, the effects of bLF on Lipopolysaccharide (LPS)-induced BEAS-2B cells and its anti-reactive oxygen species (ROS), anti-inflammatory, and antiapoptotic effects were studied via Cell Counting Kit-8 (CCK-8) test, active oxygen detection test, ELISA, and western blot assay. Transcriptome analysis revealed that two hub gene modules of DEGs were screened via PPI analysis using the STRING and MCODE plug-ins of Cytoscape. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that these core modules are enriched in the PPAR (peroxisome proliferator-activated receptor) and AMPK (AMP-activated protein kinase) signaling pathways. Through cell experiments, our study shows that bLF can inhibit ROS, inflammatory reaction, and LPS-induced BEAS-2B cell apoptosis, which are significantly antagonized by the PPAR-γ inhibitor GW9662.CONCLUSIONThis study has suggested that the PPAR-γ pathway is the critical target of bLF in anti-inflammatory reactions and apoptosis of ALI, which provides a direction for further research.

2024-12-01·Poultry Science

Bovine lactoferrin alleviates aflatoxin B1 induced hepatic and renal injury in broilers by mediating Nrf2 signaling pathway

Article

作者: Riaz, Roshan ; Chen, Shulin ; Shah, Qurban Ali ; Ahmed, Nisar ; Buzdar, Jameel Ahmed ; Fouad, Dalia ; Chen, Hong

Aflatoxin B1 (AFB1) a mycotoxin found in chicken feed that possess a global hazard to poultry health. However different potent compounds like bovine lactoferrin (bLF) may prove to be protective effects against AFB1. This study aims to explore the protective effect of bLF against AFB1-induced injury in the liver and kidney in broiler. For this purpose, 600 broilers chicks were randomly alienated into 5 groups (n = 120 each): negative control; positive control (3 mg/kg AFB1), and bLF high, medium, and low dosage groups (600 mg/kg, 300 mg/kg, and 150 mg/kg, respectively). The results highlight that AFB1 toxicity in birds exhibited low feed intake, reduction in weight gain, and a decrease in FCR while, bLF regulated these adverse effects. Meanwhile, AFB1 group showed higher levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) and lower levels of superoxide dismutase (SOD) and glutathione (GSHpx) in liver, while urea and creatinine were decline in kidney. Supplementation with bLF effectively controlled these biomarkers and control the negative effects of toxicity. Furthermore, hematoxylin and eosin (H&E) staining exhibited normal morphological structures within liver and kidney in the bLF treated groups, while degenerative changes were observed in AFB1 group. Similarly, bLF, decreased oxidative stress and thus prevented apoptosis in the liver and kidney cells of the birds. Whereas, mRNA level of mitochondrial apoptosis related gene including Bcl-2 (Bak and Bax), caspase-3 and caspase-9 was upregulated, while bcl2 gene were downregulated in AFB1 group. Dietary supplementation of bLF effectively normalizes the expression of these genes. AFB1 exposed birds shown to decrease gene expression level of the crucial component of Nrf2 pathway, responsible to regulate antioxidant defense. Interestingly, bLF reverse these detrimental effects of and restore the normal expression levels of Nrf2 pathway. Conclusively, our findings demonstrate that bLF mitigates the detrimental effects of AFB1, besides regulation of the apoptosis-related genes via mitochondrial pathways. These findings validate that the bLF (600 mg/kg) could be used as protective agent against AFB1-induced liver and kidney damage.

100 项与 Bovine lactoferrin (University of Queensland) 相关的药物交易

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研发状态

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临床结果

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分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed \| J Postgrad Med	N/A	腹泻	-	Bovine Lactoferrin	積願窪蓋繭壓積簾製觸(積膚艱醖膚築繭蓋積淵) = 簾獵衊鬱構構夢鹹顧淵鬱鬱繭窪憲遞簾鹽鹽鬱 (構夢窪鹽製鬱鏇廠鬱襯 ) 更多	积极	2013-02-01
Pubmed \| J Postgrad Med	N/A	腹泻	-	Bovine Lactoferrin (Placebo)	積願窪蓋繭壓積簾製觸(積膚艱醖膚築繭蓋積淵) = 範憲積遞壓繭餘淵積網鬱鬱繭窪憲遞簾鹽鹽鬱 (構夢窪鹽製鬱鏇廠鬱襯 ) 更多	积极	2013-02-01
ARVO2008	N/A	-	-	Bovine Lactoferrin	(齋選網衊鑰鑰艱憲網遞) = 壓鑰構蓋構醖鏇鹹繭鹹選糧獵餘顧遞遞選遞蓋 (餘獵構願糧築蓋鑰選範 )	-	2008-05-01