Effects of Combination Therapy With an α1-blocker (Sustained-release Preparation of Bunazosin or Doxazosin) in Inadequate Responders to an Angiotensin II Antagonist (Valsartan) in the Treatment of Patients With Mild to Moderate Essential Hypertension

The purpose of this study is to investigate the efficacy and safety of Bunazosin with Valsartin compared to Doxazosin with Valsartin for patients with mild to moderate essential hypertension accompanied by metabolic syndrome.

开始日期2005-10-01

申办/合作机构

Eisai, Inc.

[+1]

100 项与盐酸布那唑嗪相关的临床结果

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100 项与盐酸布那唑嗪相关的转化医学

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100 项与盐酸布那唑嗪相关的专利（医药）

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276

项与盐酸布那唑嗪相关的文献（医药）

2023-11-13·Investigative Opthalmology & Visual Science

Topical Application of Bunazosin Hydrochloride Suppresses Myopia Progression With an Increase in Choroidal Blood Perfusion

Article

作者: Jeong, Heonuk ; Kurihara, Toshihide ; Jiang, Xiaoyan ; Negishi, Kazuno ; Lee, Deokho ; Tsubota, Kazuo

PurposeThe incidence of myopia has rapidly increased in recent decades, making it a growing public health concern worldwide. Interventions to suppress the progression of myopia are needed; one suggested strategy is the prevention of choroidal thinning, which can improve choroidal blood perfusion (ChBP). Bunazosin hydrochloride (BH) is an alpha1-adrenergic blocker and commercialized glaucoma eye drop that increases in blood circulation in the eye. In this study, we evaluated the efficacy of BH in suppressing the progression of myopia in a lens-induced murine model.MethodsLens-induced myopia was induced in 3-week-old C57BL/6 J mice with -30 diopter (D) lenses for three weeks. Refractive error, axial length, and choroidal thickness were evaluated at three and six weeks of age using an infrared photorefractor and a spectral domain optical coherence tomography (OCT) system. Moreover, ChBP and scleral thickness were evaluated using swept-source OCT and histological analysis.ResultsCompared with the controls, the administration of BH eye drops suppressed the myopic shift of refractive error (mean difference ± standard error in the eye with -30 D lens, -13.65 ± 5.69 D vs. 2.55 ± 4.30 D; P < 0.001), axial elongation (0.226 ± 0.013 mm vs. 0.183 ± 0.023 mm; P < 0.05), choroidal thinning (-2.01 ± 1.80 µm vs. 1.88 ± 1.27 µm; P < 0.001), and scleral thinning (11.41 ± 3.91 µm vs. 19.72 ± 4.01 µm; P < 0.01) with myopia progression and increased ChBP (52.0% ± 4.1% vs. 59.5% ± 6.3%; P < 0.05). The suppressive effect of BH eye drops was dose-dependent and higher than that of other glaucoma eye drops and alpha1 blockers.ConclusionsThese results demonstrate the potential of BH eye drops in the treatment of myopia and support further investigation of their efficacy in humans. Further studies are needed to determine the mechanism of action and long-term safety of this treatment.

2017-02-01·Biosensors and Bioelectronics1区 · 工程技术

Nanodiamonds on tetrahedral amorphous carbon significantly enhance dopamine detection and cell viability

1区 · 工程技术

Article

作者: Niklas Wester ; Emilia Peltola ; Tomi Laurila ; Katherine B. Holt ; Jari Koskinen ; Vesa Myllymäki ; Leena-Sisko Johansson

We hypothesize that by using integrated carbon nanostructures on tetrahedral amorphous carbon (ta-C), it is possible to take the performance and characteristics of these bioelectrodes to a completely new level. The integrated carbon electrodes were realized by combining nanodiamonds (NDs) with ta-C thin films coated on Ti-coated Si-substrates. NDs were functionalized with mixture of carboxyl and amine groups ND_andante or amine ND_amine, carboxyl ND_vox or hydroxyl groups ND_H and drop-casted or spray-coated onto substrate. By utilizing these novel structures we show that (i) the detection limit for dopamine can be improved by two orders of magnitude [from 10µM to 50nM] in comparison to ta-C thin film electrodes and (ii) the coating method significantly affects electrochemical properties of NDs and (iii) the ND coatings selectively promote cell viability. ND_andante and ND_H showed most promising electrochemical properties. The viability of human mesenchymal stem cells and osteoblastic SaOS-2 cells was increased on all ND surfaces, whereas the viability of mouse neural stem cells and rat neuroblastic cells was improved on ND_andante and ND_H and reduced on ND_amine and ND_vox. The viability of C6 cells remained unchanged, indicating that these surfaces will not cause excess gliosis. In summary, we demonstrated here that by using functionalized NDs on ta-C thin films we can significantly improve sensitivity towards dopamine as well as selectively promote cell viability. Thus, these novel carbon nanostructures provide an interesting concept for development of various in vivo targeted sensor solutions.

2014-06-01·Endocrinology2区 · 医学

Repetitive Hypoglycemia Increases Circulating Adrenaline Level with Resultant Worsening of Intimal Thickening After Vascular Injury in Male Goto-Kakizaki Rat Carotid Artery

2区 · 医学

Article

作者: Ohmura, Chie ; Kawamori, Ryuzo ; Mita, Tomoya ; Azuma, Kosuke ; Watada, Hirotaka ; Kanazawa, Akio ; Fujitani, Yoshio ; Osonoi, Yusuke ; Yasunari, Eisuke ; Goto, Hiromasa

Hypoglycemia associated with diabetes management is a potential risk for cardiovascular diseases. However, the effect of hypoglycemic episodes including a surge of sympathetic activity on the progression of neointima formation after vascular injury remains largely unknown. In this study, insulin was injected intraperitoneally into nonobese diabetic Goto-Kakizaki (GK) rats, once every 3 days for 4 weeks after balloon injury of carotid artery to induce hypoglycemia. Then, we evaluated balloon injury-induced neointima formation. Insulin treatment enhanced neointima formation and increased the number of proliferating cell nuclear antigen (PCNA)-positive cells in the carotid artery. Injection of glucose with insulin prevented hypoglycemia and abrogated intimal thickening. Also, bunazosin, an α1 adrenergic receptor antagonist, prevented intimal thickening and accumulation of PCNA-positive cells induced by insulin treatment despite the presence of concomitant hypoglycemia and high adrenaline levels. Incubation of cultured smooth muscle cells with adrenaline resulted in a significant increase in their proliferation and G0/G1 to S phase progression, which was associated with activation of extracellular signal-regulated kinase, enhanced expression of cell cycle regulatory molecules such as cyclin D1, and cyclin E, and phosphorylation of retinoblastoma protein. These adrenaline-induced effects were abrogated by bunazosin. Our data indicated that increased adrenaline induced by repetitive hypoglycemia promotes intimal thickening and smooth muscle cell proliferation after endothelial denudation in GK rats.

100 项与盐酸布那唑嗪相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01887	盐酸布那唑嗪	C02	DB12230

研发状态

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适应症	国家/地区	公司	日期
青光眼	日本	Santen Pharmaceutical Co., Ltd.	2001-06-20
心脏衰竭	日本	Eisai Co., Ltd.	1995-02-28
原发性高血压	日本	Eisai Co., Ltd.	1985-04-16
肾性高血压	日本	Eisai Co., Ltd.	1985-04-16

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2003	N/A	-	-	Bunazosin Hydrochloride 0.01%	餘窪窪鏇觸構襯夢觸顧(繭餘襯窪鑰願鏇艱顧獵) = 顧夢夢夢觸製構淵製艱糧築壓顧膚窪鑰醖觸獵 (簾餘醖積窪膚築獵艱顧 )	积极	2003-05-01
ARVO2002	N/A	-	-	Nipradilol (1%)	(壓遞餘獵夢觸遞襯窪廠) = 夢襯艱觸衊艱壓築壓衊蓋齋築鬱夢顧築範範積 (簾觸觸簾憲鏇衊餘廠膚 )	积极	2002-12-01
ARVO2002	N/A	-	-	Timolol (0.5%) and Bunazosin (0.125%)	(壓遞餘獵夢觸遞襯窪廠) = 蓋蓋獵鹽憲簾範窪簾製蓋齋築鬱夢顧築範範積 (簾觸觸簾憲鏇衊餘廠膚 )	积极	2002-12-01