Human Cord Derived MSC (Life science)

The aim of this study is to assess the safety and efficacy of human umbilical cord-derived allogenic mesenchymal stem cells (MSCs) engineered to express antitumor chemokine and co-stimulatory molecule. Following systemic administration, these cells are able to migrate into solid tumors such as colorectal tumors. Once enriched in the tumor, they will attract peripheral lymphocytes consisting of T and natural killer (NK) cells, and simultaneously stimulate the infiltrated lymphocytes for persistent and enhanced antitumor immunity. Thus, this MSC-based treatment provides a potentially effective and targeted immunotherapeutic strategy for tumors with unfavorable immune microenvironment and possibly poor response to immune checkpoint blockade (ICB).
During this investigator-initiated trial (IIT), colorectal cancer patients will receive modified MSCs every 21 days via intravenous infusion. Increasing does will be tested in the initial cohort and an optimal dose will be chosen for the remaining patients.

主要目的 -探索人脐带间充质干细胞治疗特发性肺纤维化（IPF）的安全性和耐受性。 次要目的 -探索人脐带间充质干细胞治疗特发性肺纤维化（IPF）的初步有效性，为后续临床研究推荐合适的细胞治疗剂量。 -探索人脐带间充质干细胞注射液治疗特发性肺纤维化（IPF）的免疫原性。