Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their effectiveness might yield promising antibacterial, antiplaque and anticariogenic agents with minimal side effects.
Aim of the study:
Part I: The aim of this in-vitro part of the study is to formulate a nontoxic mouthwash from MO leaves extract, having antimicrobial activity, to be used in part II of the study. Furthermore, stability and efficacy of the developed mouth wash will be evaluated.
Part II: The aim of this randomized controlled trial is to evaluate the antibacterial, antiplaque and anticariogenic effect of MO mouthwash compared to chlorhexidine mouthwash.

开始日期2025-07-01

申办/合作机构

Misr International University

CTRI/2024/08/072906 / Not yet recruiting临床2/3期IIT

A Comparative pharmacotherapeutic study on Shigru kandatwaka (Moringa oleifera Lam.) and Madhushigru kandatwaka (Moringa concanensis Nimmo.) in Sandhigatavata - A

开始日期2024-11-01

申办/合作机构-

CTRI/2024/08/072682 / Not yet recruiting临床2期IIT

Comparative evaluation of locally delivered moringa oleifera gel and chlorhexidine gel as an adjunct to scaling and root planing in generalized periodontitis patients - A randomised cotrolled study - Nil

开始日期2024-10-21

申办/合作机构-

100 项与辣木提取物相关的临床结果

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100 项与辣木提取物相关的转化医学

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100 项与辣木提取物相关的专利（医药）

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项与辣木提取物相关的文献（医药）

2023-12-01·International Journal of Biological Macromolecules

Moringa oleifera leaf polysaccharide regulates fecal microbiota and colonic transcriptome in calves

Article

作者: Li, Hangfan ; Liu, Guangbin ; Li, Yaokun ; Zhao, Chao ; Liu, Dewu ; Sun, Baoli ; Tian, Hanchen ; Gao, Chongya ; Guo, Yongqing

This study investigated the effects of Moringa oleifera polysaccharide on growth performance indicators, serum biochemical indicators, immune organ indicators, colonic morphology, colonic microbiomics and colonic transcriptomics in newborn calves. 21 newborn calves were randomly divided into three groups of 7 calves per treatment group: control group (no Moringa oleifera polysaccharide addition); low-dose group (Moringa oleifera polysaccharide 0.5 g/kg); and high-dose group (Moringa oleifera polysaccharide 1 g/kg). This trial used gavage to feed MOP to calves. The test lasted 8 weeks. Calves were humanely electroshocked on the last day of the trial and slaughtered afterwards. Thymus, spleen, blood and colonic contents were collected for further testing. The results of this trial showed that MOP significantly increased the body weight of newborn calves and reduced the rate of calf diarrhea, thus promoting calf growth. Fecal scores showed a linear decrease with the addition of MOP. In terms of serum biochemistry, feeding MOP significantly increased serum ALB levels in a linear fashion. In terms of serum antioxidants, feeding MOP linearly increased CAT and T-AOC levels and decreased MDA concentrations, and in terms of serum immunity, feeding MOP linearly increased IgA, IgG, and IgM levels. At the same time, MOP regulated the abundance of Firmicutes and Bacteroidetes in the intestinal tract of calves, which reduced the occurrence of diarrhea. In addition, moringa polysaccharide could regulate genes related to inflammatory signaling pathways such as MAPK signaling pathway, TGF-beta signaling pathway, PI3K-Akt signaling pathway and TNF signaling pathway in calves' intestine to reduce the occurrence of intestinal inflammation. In conclusion, MOP can be used as a novel ruminant additive for the prevention of enteritis in calves.

2023-12-01·Doklady Biochemistry and Biophysics

Hepatoprotective Effect of Moringa Oil on Rats under Fungicide Toxicity

Article

作者: Almalki, Daklallah A ; Alotaibi, Khalid S

The present study is designed to evaluate whether pretreatment with moringa would have a protective effect on thioacetamide (TAA)-induced liver fibrosis, assessing biochemical and histopathological changes in Wistar male rats. Exposure to TAA induced notable biochemical and histopathological alterations. Liver fibrosis induced by TAA, along with associated biochemical and histological damage, has not been previously investigated in male rats supplemented with moringa oil. The experiment involved forty male rats distributed across four groups, each comprising ten rats. Group 1 served as controls and received intraperitoneal injections of saline solution twice weekly for six weeks. Group 2 rats were injected with 300 mg/kg body weight of TAA (Sigma-Aldrich Corp.) twice weekly for the same duration. Group 3 rats were orally supplemented with moringa oil at 800 mg/kg body weight/day and received intraperitoneal injections of TAA at the same dosage as Group 2 for six weeks. Finally, Group 4 rats were injected with saline solution twice weekly and orally supplemented with moringa oil at 800 mg/kg body weight/day for the same period. At the end of the experiment, we determined body weight and performed liver function analysis. Additionally, we examined the liver histology of the different groups. Results showed that moringa oil treatment protected rat livers from TAA toxicity by improving liver function analysis and preventing liver fibrosis. Moringa oil can be considered a promising agent for protection against TAA toxicity.

2023-06-19·International journal of molecular sciences

Effects of Moringa oleifera Seed Oil on Cultured Human Sebocytes In Vitro and Comparison with Other Oil Types.

Article

作者: Zouboulis, Christos C ; Weylandt, Karsten H ; Hossini, Amir M ; Hou, Xiaoxiao ; Pietzner, Anne ; Wang, Chaoxuan

The seeds of Moringa oleifera (horseradish tree) contain about 40% of one of the most stable vegetable oils (Moringa seed oil). Therefore, the effects of Moringa seed oil on human SZ95 sebocytes were investigated and were compared with other vegetable oils. Immortalized human SZ95 sebocytes were treated with Moringa seed oil, olive oil, sunflower oil, linoleic acid and oleic acid. Lipid droplets were visualized by Nile Red fluorescence, cytokine secretion via cytokine antibody array, cell viability with calcein-AM fluorescence, cell proliferation by real-time cell analysis, and fatty acids were determined by gas chromatography. Statistical analysis was performed by the Wilcoxon matched-pairs signed-rank test, the Kruskal-Wallis test and Dunn's multiple comparison test. The vegetable oils tested stimulated sebaceous lipogenesis in a concentration-dependent manner. The pattern of lipogenesis induced by Moringa seed oil and olive oil was comparable to lipogenesis stimulated by oleic acid with also similar fatty acid secretion and cell proliferation patterns. Sunflower oil induced the strongest lipogenesis among the tested oils and fatty acids. There were also differences in cytokine secretion, induced by treatment with different oils. Moringa seed oil and olive oil, but not sunflower oil, reduced the secretion of pro-inflammatory cytokines, in comparison to untreated cells, and exhibited a low n-6/n-3 index. The anti-inflammatory oleic acid detected in Moringa seed oil probably contributed to its low levels of pro-inflammatory cytokine secretion and induction of cell death. In conclusion, Moringa seed oil seems to concentrate several desired oil properties on sebocytes, such as high content level of the anti-inflammatory fatty acid oleic acid, induction of similar cell proliferation and lipogenesis patterns compared with oleic acid, lipogenesis with a low n-6/n-3 index and inhibition of secretion of pro-inflammatory cytokines. These properties characterize Moringa seed oil as an interesting nutrient and a promising ingredient in skin care products.

项与辣木提取物相关的新闻（医药）

2024-01-17

·PRNewswire

Green Virgin Products' Moringa Oil Wins Award for Best Natural Beauty Product for 2024

NEW YORK, Jan. 17, 2024 /PRNewswire/ -- HealthXWire has recognized Green Virgin Products' Moringa Oil, the all-natural, certified organic, non-toxic skin and hair care treatment, with the Best Natural Beauty Product for 2024 award. The judges cited the outstanding beneficial qualities of this unprocessed, 100% pure, and easy-to-apply oil which traces its history to Northern India's Ayurvedic medicine over 4,000 years ago. A timeless tradition of beneficial personal care values Continue Reading HealthXWire has recognized Green Virgin Products' Moringa Oil, the all-natural, certified organic, non-toxic skin and hair care treatment, with the Best Natural Beauty Product for 2024 award. The judges cited the outstanding beneficial qualities of this unprocessed, 100% pure, and easy-to-apply oil which traces its history to Northern India's Ayurvedic medicine over 4,000 years ago. Green Virgin Products was founded in 2009 by Ken Marion after realizing that many individuals do not know that many personal and home care products contain toxic chemicals that could be harmful to their health. Green Virgin Moringa Oil is extracted from the seeds of the moringa oleifera tree, found in tropical and subtropical countries around the world; its nutrient richness has helped the plant survive drought and harsh environmental conditions. The healing and beautifying benefits of Moringa Oil have been documented for thousands of years; in India's ancient Ayurvedic holistic tradition, it is even believed to prevent hundreds of diseases. [See full press release.] Modern scientific research has verified that Moringa contains the health-promoting properties of 90 different nutrients, including 46 antioxidants, proteins, and 36 anti-inflammatory agents, as reported by the NIH. Moringa Oil is rich in cytokinins and zeatin, which encourage cell vitality and slow the aging process; it is chemical-free, non-toxic, and gentle in its moisturizing, strengthening, and healing qualities. "The global moringa products market is projected to grow from USD 7.79 billion in 2021 to USD 14.80 billion in 2028 at a CAGR of 9.63%" (Fortune Business Insights). The company Green Virgin Products was founded in 2009 by Ken Marion after realizing that many individuals do not know that many personal and home care products contain toxic chemicals that could be harmful to their health:"That's when we decided to start a company that would offer non-toxic, eco-friendly, healthy products. We wanted the people buying our products to feel confident about the fact that every single product they purchase would contain zero toxins and that all our production methods were environmentally friendly." Green Virgin is proud to source its Moringa Oil exclusively from small organic growers. "This ensures the oil's high potency and preservation of properties that make this product so remarkable," adds Jeremy Marion, VP of Operations. The company's Moringa Oil is always 100% pure, extra virgin, cold-pressed, certified organic, and free of preservatives and chemicals. Other Green Virgin products include Soap Nut, Moringa, Citrus Shampoo; Moringa Oil, Citrus, Conditioner; and Soap Nut, Moringa Bar Soap. [See full press release.] About: HealthXWire is a digital publication serving an audience located primarily in the United States. Contact: Karl Klinger 212-378-9964 [email protected] SOURCE HealthXwire; Green Virgin Products