Clinical and Radiographic Evaluation of Immediate Implant Placement Utilizing Vestibular Flap Versus Single Flap Approach With Bone Graft in Anterior Maxilla: A Randomized Clinical Trial

Due to the evolution of esthetic implant dentistry and tissue regeneration (hard and soft tissue), flap design plays a crucial role in the maintenance and regeneration of the marginal soft tissue and interdental papillae around dental implants. The present study aims to compare soft and hard tissue changes following immediate implant placement with ridge augmentation using the vestibular flap versus single flap approach.

开始日期2025-09-01

申办/合作机构

Misr International University

NCT06207617

/ Not yet recruitingN/AIIT

Evaluation of Soft and Hard Tissue Dimensional Changes Following Immediate Implant Placement in Molar Extraction Sockets With or Without Bone Graft: A Randomized Controlled Clinical Trial

Statement of problem: The majority of studies on immediate implant placement are related to the maxillary esthetic zone. Literature concerning Immediate implant placement in the posterior region is scarce. Furthermore, there is paucity of evidence on alveolar bone dimensional changes following immediate implant placement in fresh extraction sockets of posterior teeth. Adding to that, negligible evidence is known about the soft tissue alterations which take place during modeling and remodeling phases of socket healing process; regarding the molar sites. Nevertheless, Immediate installation into a molar socket raises an extra challenge for the clinicians, because of the different anatomical features of the extraction sockets compared to that of the single-rooted teeth in the anterior zone. In addition to, implant positioning difficulties; due to the amount of the residual inter-radicular bone after extraction. Aim of the study: To assess the bucco-lingual ridge collapse after immediate implant placement in lower 1st molar sites either with customized healing abutment only; or with xenogeneic bone graft and customized healing abutment. Materials and methods: The current study will include 28 non-restorable lower 1st molar teeth indicated for extraction in the posterior area. Patients will randomly be assigned into two equal groups: the test group; Immediate implant placement + customized healing abutment group and the control group; Immediate implant placement +bone graft+ customized healing abutment group. The presented trial will investigate the following outcomes: bucco-lingual ridge collapse as the primary outcome, together with mid-facial recession, total volume gain/loss, buccal soft tissue contour, bucco-lingual bone width, and vertical bone changes as the secondary outcomes after 12 months

开始日期2025-08-01

申办/合作机构

Misr International University

NCT06207604

/ Not yet recruitingN/AIIT

Survivability of Dental Implants Placed in Atrophic Maxillae Using Open Sinus Elevation Technique With and Without Bone Grafting Material. A Randomized Controlled Clinical Trial

The success rate of dental implants after graftless sinus augmentation versus conventional sinus augmentation surgery in atrophic maxillae in edentulous patients was investigated and it was concluded that despite the bone gain in ten garftless side, implant survival were significantly lower in the non-grafted side. One year later, Lie et al., conducted a systematic review to evaluate efficacy of graftless maxillary sinus membrane elevation using the lateral window approach for implantation in the atrophic maxilla. It showed a high implant survival rate in non-grafted maxillary sinus lifts and conventional sinus lifts using augmentation materials and there was no significant difference in the ISQ values between both procedures. However, further randomized clinical trials with long-term follow-up were recommended.

开始日期2025-08-01

申办/合作机构

Misr International University

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2025-05-01·Pathology - Research and Practice

FCGR1A(CD64) expression on monocyte subsets and FIL1Z(IL-37) serum level as biomarkers of rheumatoid arthritis activity: A case controlled study and in silico analysis

Article

作者: Hamdy, Nadia M ; Ali Abd El Rahim, Marwa Mohamed M ; Rezk, Mohamed Sobhy Mahmoud ; Kasim, Sammar Ahmed ; Mohamed, Maha S ; Mohamed, Eman Fekry ; Mohammed, Rehab Abd Elfattah ; Gad, Lamia A ; Mokhtar, Entsar R ; El Magdoub, Hekmat M ; Hussein, Neama R ; Abd El-Fattah, Doaa Aly ; Fathy, Doaa ; Elhadad, Sara M ; Elhakeem, Heba

Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases. Chronic joint inflammation and bone destruction were shown to be caused by expanded monocytes in RA affected individuals. Interleukin-37 which known as FIL1Z(IL-37) is a well-known anti-inflammatory cytokine that plays a negative regulatory role of inflammation in RA. A total of 48 RA patients were divided equally into active RA group and stable RA group using the Disease Activity score (DAS)-28 score. Twenty-four age-and sex-matched healthy subjects were enrolled as controls. The expression level of Fc gamma receptor IA (FCGR1A(CD64)) on monocytes and their subsets in peripheral blood were assessed by flow cytometry (FC) and serum levels of FIL1Z(IL-37) were measured by ELISA. The mean fluorescence intensity (MFI) of FCGR1A(CD64) expressing classical and intermediate monocyte subsets and serum levels of FIL1Z(IL-37) were significantly elevated in RA patients compared to the control and positively correlated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) and DAS-28 scores. The MFI of FCGR1A(CD64) expressing classical monocyte and serum levels of FIL1Z(IL-37) were significantly elevated in the active RA group compared to the stable RA group. The serum concentration of FIL1Z(IL-37) revealed very high specificity but limited sensitivity in discriminating between active and stable RA patients. Our results demonstrate a strong correlation between serum levels of FIL1Z(IL-37) and FCGR1A(CD64) expression on activated monocytes and their subsets in peripheral blood of RA patients. The results also depict that activated monocytes and their subsets may contribute to the elevated levels of FIL1Z(IL-37) during an active disease status to counter-act the inflammatory process.

2025-04-21·Cancer Research

Abstract 7416: Prevalence of IL28B single nucleotide polymorphism Rs12979860 and cytomegalovirus (CMV) among allogeneic stem cell transplant in leukemia children

作者: Srivastava, Sanjay K. ; Eltokhy, Mohamed A. ; Madney, Youssif ; Gamal, Israa ; Mansour, Tarek ; Radwan, Sahar ; Eltoukhy, Omar A. ; Farag, Mohamed M.

AbstractCytomegalovirus (CMV) remains a significant cause of morbidity and mortality among allogeneic stem cell transplant (allo-SCT) recipients especially in pediatric leukemia patients. IFN-λ family: interleukin (IL)-28A, -28B, and -29 and IFN-λ4. All have antiviral properties similar to IFN-α. In vivo, IFN-λs are mostly secreted by dendritic cells (DC) and macrophages. IL-28B signals through a heterodimeric receptor consisting of IL-28R1 chains and IL-10Rβ, hence inducing an antiviral state. It has been shown that screening allo-SCT recipients for the presence of defined polymorphisms in genes involved in the regulation and activation of innate and adaptive immune responses may help to predict their individual risk of viral infection and disease. Our study aims to investigate the prevalence of single nucleotide polymorphism (SNP) (rs12979860), upstream of the IL28B gene among allo-SCT recipients and to investigate whether that SNP has any effect on the incidence rate and the features of active CMV infection in cancer children receiving stem cell transplantation. Thirty-five patients undergoing allo-SCT in 57357 children’s cancer hospital were included in the study (age range, 2-20 years). A total of thirty-five whole blood samples were collected. DNA Extraction from Blood Samples was performed by using ThermoScientific GeneJet genomic DNA purification kit, IL28B SNP Analysis L28B (rs12979860) genotyping was performed by RT-qPCR (Applied Biosystems TaqMan SNP genotyping assay) using QuantStudio ViiA7 system, and routine screening of CMV was performed once a week by real-time PCR (ViroGene real-time CMV quantification kit). The prevalence of single nucleotide polymorphism (SNP) (rs12979860), upstream of the IL28B gene among allo-SCT in cancer children was as follows: C/C carriers were 34.3%, C/T carriers were 42.8% and T/T carriers were 22.8%, 37.1% of patients had one or more episodes of active CMV infection during the first 100 days following allo-SCT. Patients carrying the homozygous T allele had a shorter duration of initial active CMV infection than those carrying the homozygous or heterozygous C-allele. Also, Patients carrying the homozygous T allele show a lower magnitude of CMV DNA viral load within their initial episodes of CMV infection compared to the C/C and C/T groups. Data from the current study showed a protective effect of the homozygous T allele of IL28B SNP (rs12979860) against CMV infection in cancer patients undergoing allo-SCT, T/T carriers showed a lower incidence of active CMV infection episodes occurring within 100 days after allo-SCT, those episodes were shorter in duration and lower in magnitude compared to patients carrying C/C and C/T allele. These findings emphasize the potential for personalized risk assessment and management strategies in pediatric allo-SCT recipients based on IL28B SNP profiling.Citation Format:Mohamed A. Eltokhy, Israa Gamal, Omar A. Eltoukhy, Youssif Madney, Mohamed M. Farag, Tarek Mansour, Sanjay K. Srivastava, Sahar Radwan. Prevalence of IL28B single nucleotide polymorphism Rs12979860 and cytomegalovirus (CMV) among allogeneic stem cell transplant in leukemia children [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 7416.

2025-04-01·Cytokine

Unveiling NLR pathway signatures: EP300 and CPN60 markers integrated with clinical data and machine learning for precision NASH diagnosis

Article

作者: Guirguis, Reginia Nabil Mikhail ; Khairy, Eman ; El-Attar, Noha E ; Ghani, Amani Mohamed Abdel ; Abdelbaky, Ibrahim ; Barakat, Eman ; Saad, Maha ; Matboli, Marwa ; Hamady, Shaimaa ; Khaled, Radwa

BACKGROUNDGiven the increasing prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and non-alcoholic steatohepatitis (NASH), there is a critical need for accurate non-invasive early diagnostic markers.OBJECTIVEThis study aimed to validate NLRP3-related RNA signatures (EP300, CPN60, and ITGB1 mRNAs, miR-6881-5p, and LncRNA-RABGAP1L-DT-206) using an integrated molecular approach and advanced machine-learning algorithms to identify robust biomarkers for early diagnosis of NASH.METHODSA cohort of 237 participants (117 Healthy controls, 60 MAFLD, 120 NASH) was utilized. Twenty-five demographic, clinical, and molecular features were collected from each participant. Various machine learning models were trained on the dataset.RESULTSThe Random Forest algorithm emerged as the most effective classifier. The model identified nine key features: EP300 mRNA, CPN60 mRNA, AST, D. bilirubin, Albumin, GGT, HbA1c, HOMA-IR, and BMI, achieving an impressive 97 % accuracy in distinguishing NASH from non-NASH cases.CONCLUSIONThe integration of molecular, clinical, and demographic data with machine learning algorithms provides a highly accurate method for the early diagnosis of NASH. This model holds promise for early detection in individuals at risk of progressing to cirrhosis or liver cancer and may aid in identifying new therapeutic targets for managing NASH.

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