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更新于：2026-09-08
Hydroxypropyl Cellulose
羟丙纤维素
更新于：2026-09-08
概要
基本信息
在研机构- |
非在研机构 |
权益机构- |
最高研发阶段撤市 |
首次获批日期 美国 (1981-06-01), |
最高研发阶段(中国)- |
特殊审评- |
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关联
1
项与 羟丙纤维素 相关的临床试验NCT03079271
An Open Label Comparing the Short Term Efficacy of Lacrisert
100 项与 羟丙纤维素 相关的临床结果
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100 项与 羟丙纤维素 相关的转化医学
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100 项与 羟丙纤维素 相关的专利（医药）
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185
项与 羟丙纤维素 相关的文献（医药）2026-08-05ACS Applied Materials & Interfaces
High-Strength, Tunable Thermoresponsive, Biocompatible, and Highly Sensitive Sensing Properties of Freeze-Thaw-Regulated Poly(acrylic acid)/Hydroxypropyl Cellulose Hydrogels
Article
作者: Xie, Yifan ; Zhang, Xi ; Zou, Jincheng ; Wang, Senmiao ; Fan, Minmin
Abstract:
A physically crosslinked multifunctional hydrogel based on poly(acrylic acid)/hydroxypropyl cellulose/aluminum chloride (PAA/HPC/AlCl3) was developed for flexible sensing applications. The network, constructed solely through hydrogen bonds and Al3+ coordination bonds, exhibits stretchability, adhesiveness, and reversible thermochromism. Freeze-thaw cycling serves as a green physical strategy to regulate performance: after treatment, tensile strength increased from 0.11 to 3.60 MPa, hysteresis strain decreased from 35 to 9.5%, and dissipated energy rose from 7.839 to 53.699 MJ·m–3. Low-field NMR reveals that freeze-thaw promotes water redistribution and chain aggregation, strengthening non-covalent interactions without introducing chemical crosslinkers. By adjusting Al3+ content and freeze-thaw cycles, the upper critical solution temperature (UCST) can be synergistically tuned between 15 and 54 °C, enabling reversible thermochromism. Before freeze-thaw, the hydrogel exhibits excellent adhesion, high strain sensitivity (GF = 5.4, 3–500%), high temperature sensitivity (TCR = –0.019/°C, detection limit 0.1 °C), and electromechanical self-healing, allowing accurate detection from human motion to Morse code. Post freeze-thaw, hydrogels combine high strength with stable thermoresponsive properties. In vitro hemolysis and CCK-8 assays confirmed the hydrogel's hemocompatibility and cytocompatibility. A preliminary in vivo wound contact test on rats revealed only mild, fully reversible irritation with no persistent damage. This work achieves differentiated performance regulation in a single system through a simple and environmentally friendly processing method, offering a sustainable design approach for flexible sensors.
2026-07-01JOURNAL OF PHARMACEUTICAL SCIENCES
Platform technology and alternates for cross-linking issues in soft gelatin capsules: A modified shell composition strategy for BCS class IV drug candidates
Article
作者: Nagalakshmi, S ; Ansari, Mohamed Arif ; Rajasekhar, A T ; Senthilraja, Kaliyamoorthy ; Sheikh, Shafiq-Un-Nabi ; Anusha, D
Soft gelatin capsules (softgels) are widely used oral dosage forms for BCS Class IV drug candidates, offering enhanced solubilization capacity for poorly soluble, poorly permeable active pharmaceutical ingredients. However, gelatin shells are susceptible to progressive cross-linking during storage, particularly when reactive fill components - including oxidized lipids, aldehydes, or free amino acids - are present. Cross-linking induces shell in solubilization that delays or prevents disintegration, with potential consequences for bioavailability. This study evaluated a modified gelatin shell platform incorporating hydrophilic shell-modifying excipients - hydroxypropyl methylcellulose (HPMC), Povidone K30, and hydroxypropyl cellulose (HPC/Klucel LF) as water-soluble polymers, and microcrystalline cellulose (MCC PH105) as a water-insoluble but highly hydrophilic swellable particulate - as formulation-level cross-linking mitigation strategies. Six modified formulations (FT1-FT6) and six conventional gelatin-glycerin controls (FC1-FC6) were encapsulated with reactive fill systems, including aged omega-3 oils (elevated peroxide value), L-Arginine, and Glucosamine HCl/Chondroitin Sulfate combinations. Disintegration performance was assessed per USP <701> under ICH Q1A(R2)-compliant stability conditions at 25 degrees C/60% RH, 30 degrees C/65% RH, and 40 degrees C/75% RH over six months. All modified formulations maintained pharmacopeial compliance (30 min or less) throughout the full study period under all storage conditions. The Povidone K30-based system (FT4) demonstrated superior resistance to L-Arginine-induced cross-linking, with disintegration times below 12 minutes after six months of accelerated storage. In contrast, conventional formulations frequently exceeded the pharmacopeial limit, with failures recorded as early as the three-month accelerated time point. Strategic incorporation of water-soluble excipients within the gelatin matrix represents a practical, scalable, and manufacturing-compatible approach to cross-linking mitigation in softgels containing chemically reactive fills.
2026-07-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Double encapsulation with porous starch and cellulose: A strategy for enhanced probiotic protection in microcapsules and tablets
Article
作者: Kong, Lu ; Hu, Xiufa ; Na, Guoqi ; Zou, Minxin ; Liu, Xinnan ; Yang, Qingyu
Maintaining probiotic viability during tablet manufacturing and storage remains a critical challenge in functional food development. In this study, a double-layer microencapsulation system was developed using porous starch (PS) as the core carrier and cellulose derivatives (microcrystalline cellulose, MCC; hydroxypropyl cellulose, HPC; and hydroxypropyl methylcellulose, HPMC) as coating materials to enhance probiotic protection and tableting performance. Among the formulations, PS-HPMC presented the highest encapsulation efficiency, which was ascribed to the formation of a compact coating structure. The double-layer microcapsules significantly improved the stress resistance of Lactobacillus plantarum. In particular, the PS-HPMC system showed viability losses of 0.07 log CFU/g under acidic conditions and 1.97 log CFU/g under bile salt treatment, and it retained a survival rate of 44.09% after tablet compression. In vitro gastrointestinal digestion revealed a controlled release profile of probiotics, which followed the Korsmeyer-Peppas model. A viable count of 6.67 log CFU/g was maintained after digestion, demonstrating effective protection of probiotics during gastrointestinal transit. In addition, PS-HPMC tablets preserved 10.80 ± 0.02 log CFU/g after 30 days of storage at 4 °C, and the predicted shelf life based on the first-order kinetic model reached 202.6 days, indicating the double-layer structure enhanced storage stability and prolonged shelf life. The prepared tablets also exhibited satisfactory mechanical strength and disintegration properties. Overall, the cellulose-coated porous starch system effectively enhanced the viability and stability of probiotics in solid dosage forms, providing a promising strategy for the development of functional foods.
100 项与 羟丙纤维素 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 干眼综合征 | 美国 | 1981-06-01 | |
| 上皮复发性糜烂营养不良 | 美国 | 1981-06-01 | |
| 感觉减退 | 美国 | 1981-06-01 | |
| 角膜炎 | 美国 | 1981-06-01 | |
| 干燥综合征性角膜结膜炎 | 美国 | 1981-06-01 |
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