济脉通片(Jimaitong Tablets) - _专利_临床

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

心血管疾病

在研适应症-

非在研适应症

高血压

原研机构-

在研机构-

非在研机构

济民健康管理股份有限公司浙江中医学院

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)无进展

特殊审评-

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关联

1

项与济脉通片相关的临床试验

CTR20131805 / Completed临床2期

济脉通片与安慰剂平行对照治疗高血压（肝火亢盛证）随机、双盲、多中心Ⅱ期临床试验

初步评价济脉通片治疗高血压（肝火亢盛证）在降低血压，改善症状等方面的有效性和安全性。

开始日期2014-03-13

申办/合作机构

济民健康管理股份有限公司

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100 项与济脉通片相关的临床结果

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100 项与济脉通片相关的转化医学

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100 项与济脉通片相关的专利（医药）

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1

项与济脉通片相关的文献（医药）

China Journal of Chinese Matera Medica

Effect of Jimaitong tablt combined with nifedipine on blood-pressure andmechanisms investigation in spontaneously hypertensive rats

Article

作者: Fang, Qingxia ; Wu, Xiaodong ; Lv, Guiyuan ; Lv, Liangzhong ; Yu, Sheng ; Chen, Suhong

OBJECTIVETo study the effect and its mechanism of antihypertensive of drug combination of Jimaitong tablt and nifedipine on spontaneously hypertensive rats.METHODThe spontaneously hypertensive rats (SHR) were treated by intragastric administration (ig) with Jimaitong (450 mg x kg(-1)), Jimaitong (300 mg x kg(-1)) combined with the nifedipine (0.5 mg x kg(-1)), nifedipine (5 mg x kg(-1)) for 8 weeks. Blood pressure and heart rate was measured. The level of oxidation indicators, lipid indicators, as well as hormones related to blood pressure was detected.RESULTSCompared with that in the control group, systolic blood pressure, diastolic blood pressure, mean arterial pressure of SHR decreased significantly in all the three administration groups (P < 0.01). Heart rates of nifedipine group was faster than other groups (P < 0.05). In combination group, contents of URE, MDA, ET and Ang II were decreased significantly (P < 0.05, P < 0.05, P < 0.05, P < 0.01), the contents of NO and CAMP, SOD and NOS were significantly enhanced (P < 0.05).CONCLUSIONCombination use of Jimaitong and nifedipine has synergistic effects on anti-hypertension in spontaneously hypertensive rats. It indicates the potential applications of combination of traditional Chinese medicine and western medicine for the hypertension treatment.

100 项与济脉通片相关的药物交易

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